Today was the annual Remind Getaid meeting of French clinical and translational research on Inflammatory Bowel Diseases. There were great discussion and a vibrant hommage to Nicolas Barnich.

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥 shorturl.at/EImjA

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease. www.biorxiv.org/content/10.1...

T cell mediated impairment of epithelial integrity in Crohn's disease https://www.biorxiv.org/content/10.1101/2024.11.12.621219v1