These are not a ranking lists we should be topping... royalsociety.org/-/media/poli...

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

Nobel prize for Tregs! www.nobelprize.org/prizes/medic...

Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).

Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/... (Spoiler alert: he does not approve).

Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang

I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰

I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...

New research article from the lab led by the amazing @amydashwood.bsky.social ! In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11 www.sciencedirect.com/science/arti...

Last few days to apply for this:

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis. www.nature.com/articles/s41...

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...

📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community! Find out more about the position and apply: https://buff.ly/40m1udb

Many congratulations to Prof Ashley Moffett on this honour! This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.

A very rare position for an immunology professorship at Cambridge. Something to think about! www.jobs.cam.ac.uk/job/49381/

I've added a PI3K starter pack. Please help me populate it by replying to this post. #PI3K #PTEN #AKT #mTOR #FOXO go.bsky.app/7p2g5eN

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

Professorship in Immunity and Infection at the University of Cambridge: www.jobs.cam.ac.uk/job/49381/ Check out the cross-departmental infection and immunity theme for the grand challenges we want to address: www.bio.cam.ac.uk/research/inf... Application deadline: Jan 26th, 2025.

"The FDA has approved Genentech’s inavolisib (Itovebi) in combination with the CDK4/6 inhibitor palbociclib and the oestrogen-receptor antagonist fulvestrant for endocrine-resistant, PIK3CA-mutated, hormone receptor-positive, HER2-negative breast cancer." #PI3K www.nature.com/articles/d41...

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts. www.youtube.com/watch?v=tQxA...

Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA

Mice and humans develop intestinal inflammation when PI3Kdelta is inhibited. Lyn Lim, Shimon Sakaguchi and colleagues provide evidence this is secondary to defects in the differentiation and maturation of pTreg:

A starter pack for staff, students and alumni from @campathology.bsky.social. Tag me if you have a connection to Cambridge Pathology and I'll add you to the list! go.bsky.app/DCiqQL1

Listen to the interview with my brilliant colleague Rahul Roychoudhuri @roychoudhurilab.bsky.social on cancer immunotherapy, synthetic biology, the metastatic niche. And building garden rooms. Starts about 30 min into the podcast.

💡 Inspired by others, as we grow our #AcademicSky #MedSky#ImmunoSky community here @bsky.app 🦋, thought it might be cool to have a #StarterPack for #CancerImmunology. Please join in or recommend a colleague! Hope this is useful 👇 go.bsky.app/PRdmHCP

NIAID releases alternative to BioRender, all illustrations freely available in public domain bioart.niaid.nih.gov

Amazing gift from Trinity College Cambridge for 30 new PhD studentships! www.cam.ac.uk/stories/PhD-...

Is anyone else having problems with Labstep? We have used it as a free electronic lab book. Recently one of my students got an email saying they are going to start charging and now I cannot log in to my personal account... The charges they propose are prohibitive...($30 per lab member per month!)

Congratulations to Julius Baeck who successfully passed his PhD viva last week! Many thanks to Claudia Mauri and Daniel Hodson who examined his thesis and engaged in a stimulating discussion!

I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSky 🧪⚕️ go.bsky.app/PY5tCas

We have a new and unique position to join our lab as a Research Laboratory Technician at the University of Cambridge. Join an inclusive, international and diverse team, supportive of your personal and career development :) jobs.cam.ac.uk/job/44932/

Interested in a postdoc in neuroimmunology at the University of Cambridge? We have a translational position open to develop gene therapy for traumatic brain injury, with potential to transition into a spin-off company, Aila Biotech. jobs.cam.ac.uk/job/44372/

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development https://www.biorxiv.org/content/10.1101/2024.01.08.574346v1

Postdoc available in Cancer Immunology! The project, funded by the MRC, will investigate how the #PI3K pathway can be manipulated to increase anti-tumour responses, particularly in the context of cancer metastasis. Deadline for applications Jan 31, 2024 www.jobs.cam.ac.uk/job/44318/