Kristoffer H. Johansen
@krishaurum.bsky.social
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Lundbeckfonden Postdoc Fellow @ DTU 🇩🇰 T cell Immunology | TCRs | high-throughput screens | CRISPR
reposted by
Kristoffer H. Johansen
bioRxiv Immunology
3 months ago
Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells
https://www.biorxiv.org/content/10.1101/2025.11.01.686037v1
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Thanks for a lovely time in Cambridge - great to see you all again. Already looking forward to next time.
add a skeleton here at some point
4 months ago
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Our paper is now out with peer review! This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved. Read about it below in Tims breakdown!
add a skeleton here at some point
7 months ago
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reposted by
Kristoffer H. Johansen
Schumacher Lab
10 months ago
It's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
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A functionally validated TCR-pMHC database for TCR specificity model development
Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...
https://www.biorxiv.org/content/10.1101/2025.04.28.651095v2
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