We're hiring! We are looking for a Research Assistant with protein biochemistry skills to develop novel protein-based immunotherapeutics targeting Treg cells in cancer. You'll join @roychoudhurilab.bsky.social @campathology.bsky.social @crukcamcentre.bsky.social Apply: jobs.cam.ac.uk/job/53219/

Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?

A more consistently warm home, no damp on the walls in winter and much cheaper heating

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

The new #ALASCCA RCT shows that low-dose aspirin prevents metastatic recurrence by ~50% in patients with PI3K altered colorectal cancer #aspirin #metastasis #prevention

A fantastic 2 days in Lille thinking T cell therapy at CAR T Day - the 9th international symposium on CAR T cells cartday.org. Thanks to Suman Mitra for the invitation to share our new data

Cool to see so many #heatpumps being installed this year. We’ve had our heatpump at home now for 3 years and it’s been saving us money while providing more comfortable heating and reducing our estimated CO2e by 75-80%.

Please sign: petition.parliament.uk/petitions/72...

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

The limited set of sanctions the UK has placed on specific individuals in Israel is not enough. Comprehensive sanctions needed to pressure the Israeli govt to reverse course in #Gaza. Please sign this petition to Parliament: #StopIsraelNow: chng.it/tsH8ZSJfRH via @UKChange

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via @ukchange.bsky.social

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via @ukchange.bsky.social

Many wonders of aspirin 👍

T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses www.embopress.org/doi/full/10.... @iannaconelab.bsky.social

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri... @campathology.bsky.social @crukcamcentre.bsky.social

Really enjoyed discussing our recent findings and thoughts on cancer immunity with Nick Jikomes of the Mind and Matter podcast mindandmatter.substack.com/p/can-aspiri... @campathology.bsky.social @crukcamcentre.bsky.social

Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity @cp-immunity.bsky.social www.cell.com/immunity/ful...

Research Highlight of our recent paper by @jieyang437.bsky.social on Aspirin and cancer metastasis in Nature Reviews Immunology. Thanks to Yvonne Bordon for a crystal clear account of the experimental findings www.nature.com/articles/s41...

New results from the ALASCCA prospective randomised controlled trial showing daily #aspirin reduces colorectal cancer recurrence by ~50% in patients with PIK3CA or related mutations. Findings extend benefits of aspirin beyond Lynch syndrome cancers to nearly 40% of CRCs ascopubs.org/doi/10.1200/...

Reactivation of CTLA4-expressing T cells Accelerates Resolution of Lung Fibrosis in a Humanized Mouse Model @jclinical-invest.bsky.social www.jci.org/articles/vie...

Imagine if all those who are silent about the terrible evil being committed in Gaza spoke up www.theguardian.com/commentisfre...

Thank you Jae!

Huge study in @nature.com by the @roychoudhurilab.bsky.social group #Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!

Thanks for all your ideas and support with this work Klaus!

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity @nature.com @roychoudhurilab.bsky.social www.nature.com/articles/s41...

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

‘Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity’ @roychoudhurilab.bsky.social www.nature.com/articles/s41...

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells! Check 'em out! They will be available until the end of April! bit.ly/SciImm_free #KSmyeloid25

In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually. An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity www.science.org/doi/10.1126/...

Thank you for all your hard work on this Ben - the late nights paid off!

#EveryCellIsAnImmuneCell! @jieyang437.bsky.social @roychoudhurilab.bsky.social &co show @nature.com that platelet-derived thromboxane A2 suppresses T cell effector functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastasis!

Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells www.nature.com/articles/s41... @naturecomms.bsky.social

A new study published in @nature.com by Dr Jie Yang of @roychoudhurilab.bsky.social has uncovered a novel mechanism by which aspirin inhibits cancer metastasis by strengthening the body’s immune response. ➡️ Read now: www.path.cam.ac.uk/news/groundb...

Thank you Tim - it really was all Jie!

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.” www.researchamerica.org/2023-oped-us...

#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2

This is a most insightful view of PD-1 signalling. Usefully limiting signal strength to maintain the stem-like progenitors of the chronic response

REVIEW: Next-generation combination approaches for immune checkpoint therapy www.nature.com/articles/s41... @pamsharmamdphd.bsky.social

If you're looking for a great #WeekendRead, see below!

Very excited to share our latest publication on the role of NOTCH1 in sexual dimorphism in liver cancer and published in Cancer Discovery! Super proud of Katie Lindblad for leading this study as part of her outstanding PhD work.

Immunoregulatory cell death!

A while back we wrote an article calling for accelerated change in policy for those w/ caring responsibilities in #STEMM Sharing insights into the challenges, highlighting personal experiences & proposing a strategy to improve culture #AcademicSky Read it here: www.nature.com/articles/d41...

Listen to the interview with my brilliant colleague Rahul Roychoudhuri @roychoudhurilab.bsky.social on cancer immunotherapy, synthetic biology, the metastatic niche. And building garden rooms. Starts about 30 min into the podcast.

If you're looking for another great starter pack for cancer research/ oncology - check out this one compiled by @valdesan.bsky.social Thanks for including us! #oncology #cancer 🧪🔬⚕️🩺 go.bsky.app/GKXp9Fy

Added new folks to the #Immunology Starter Pack 🧪 @sarahdimeloe.bsky.social @mahimaswamy.bsky.social @profken.bsky.social @johannajoyce.bsky.social @alanmcn1.bsky.social @immunoah.bsky.social @bnmelgert.bsky.social @copperbae.bsky.social @benjaminkrishn3.bsky.social go.bsky.app/PY5tCas