The FDA approval of vepdegestrant for ESR1-mutant ER+/HER2− advanced breast cancer marks an important milestone for PROTACs! Beyond its importance for patients, this is a landmark validation of targeted protein degradation as a therapeutic modality 👏🏻 www.fda.gov/drugs/resour...

The PANoptisis hypothesis examined www.nature.com/articles/s41...

‘Triplex formation drives noncontiguous VIPR RNA-guided DNA recognition’ www.biorxiv.org/content/10.6...

‘mRNA vaccines engage unconventional pathways in CD8+ T cell priming’ www.nature.com/articles/s41...

‘Environmentally driven immune imprinting protects against allergy’ www.nature.com/articles/s41...

The Gyrd-Hansen lab uncover an important mechanism by which uORFs prevent over exuberant immunity, inflammation & tissue damage, by buffering the expression of TNFR1, IFNAR1/INFGR2, TLR4 (& mostly likely other receptors) - huge congrats all authors! www.science.org/doi/10.1126/...

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

We’re happy to share our updated manuscript on Ninj1, incorporating measurements of membrane tension, cellular assays of ninj1 and ninj2 dimer stability and MD simulations of ninj1 oligmers opening and forming (see below!). @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Valiant effort from all involved! 👏🏻

Now online! Hallmarks of cancer—Then and now, and beyond

‘Environmentally driven immune imprinting protects against allergy’ www.nature.com/articles/s41...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Last week I was privileged to attend the @britsocimm.bsky.social 2025. The congress was packed with exciting immunology updates from around the world 🌍 I was honoured to receive a 1st place prize for my bright sparks talk ‘harnessing immunogenic cell death to improve cancer therapy’ 🏆

‘Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice’ www.science.org/doi/10.1126/...

After completing my PhD last Oct, I recently graduated from the @icr.ac.uk at the beautiful guildhall. An incredibly proud moment!!

‘A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging’ www.science.org/doi/10.1126/...

‘RIPK1 autophosphorylation at S161 mediates cell death and inflammation’ rupress.org/jem/article/...

‘Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome’ 👏🏻 www.science.org/doi/10.1126/...

Obesity increases the risk of many cancers, but which fats are bad in high fat diets? [1/3] Lard, beef tallow or butter 🧈: ⤴️tumor growth coconut oil 🥥, palm oil 🌴, olive oil 🫒 do not despite equivalent obesity www.nature.com/articles/s42... @natmetabolism.nature.com

‘Humoral determinants of checkpoint immunotherapy’ www.nature.com/articles/s41...

‘Regulation of inflammatory processes by caspases’ 🔥 www.nature.com/articles/s41...

‘The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis’ www.nature.com/articles/s41...

‘VDAC2 loss elicits tumour destruction and inflammation for cancer therapy’ www.nature.com/articles/s41...

‘STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity’ www.nature.com/articles/s41...

The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

‘Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages’ www.science.org/doi/10.1126/...

‘B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine’ 🦠 www.nature.com/articles/s41...

Online now: Cytosolic cytochrome c represses ferroptosis

New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

‘MLKL activity requires a splicing-regulated, druggable intramolecular interaction’ www.sciencedirect.com/science/arti...

NEWS: NICE has recommended capivasertib for advanced #BreastCancer. The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer. Read more about the history of the drug⬇️ www.icr.ac.uk/about-us/icr...

BREAKING NEWS: #ProstateCancer spit test is better for men with high genetic risk than the standard PSA blood test. The results from the ICR's BARCODE 1 trial are published in @nejm.org More here ⬇️ icr.ac.uk/about-us/icr-news/detail/simple-spit-test-could-finally-turn-the-tide-on-prostate-cancer

impactful work from @icr.ac.uk - saliva test to identify men at risk of prostate cancer www.nejm.org/doi/full/10.... News write up here : www.bbc.co.uk/news/article...

Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial www.nature.com/articles/s41...

‘Skin damage signals mediate allergic sensitization to spatially unlinked antigen’ www.science.org/doi/10.1126/...

Whoa - are a significant proportion of sporadic ALS/motor neuron disease cases a mitochondrial DNA disease?! #mitochondria www.nature.com/articles/s41...

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells www.science.org/doi/10.1126/... @jelenalab.bsky.social

‘Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity’ www.science.org/doi/10.1126/...

We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠 For full details of the position, please visit our website: www.cruk.manchester.ac.uk/career/mi-24... Closing date: 4th April #OncoSky #CanSky #CancerResearch #microbiome

‘Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity’ @roychoudhurilab.bsky.social www.nature.com/articles/s41...

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

‘A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development’ www.nature.com/articles/s41...

‘RIPK1 is required for ZBP1-driven necroptosis in human cells’ journals.plos.org/plosbiology/...

‘RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer’ www.nature.com/articles/s41...

‘The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance’ www.cell.com/immunity/abs...

‘A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer’ www.cell.com/cancer-cell/...

‘A neoantigen vaccine generates antitumour immunity in renal cell carcinoma’ www.nature.com/articles/s41...