Broz Lab
@brozlab.bsky.social
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Lab of Petr Broz @ UNIL. Cell death, innate immunology and pathogen defense
reposted by
Broz Lab
Isabella Eckerle
3 months ago
Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine:
jobs.unige.ch/www/wd_porta...
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Professeur-e ordinaire, professeur-e associé-e (6460)
en génomique des maladies infectieuses intracellulaires Chaire dexcellence / Full Professor or Associate Professor in Genomics of Intracellular Infectious Diseases Chair of Excellence
https://jobs.unige.ch/www/wd_portal.show_job?p_web_site_id=1&p_web_page_id=71045
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Congrats to
@malvinapiz.bsky.social
and
@inflammasomelab.bsky.social
on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
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Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...
https://www.embopress.org/doi/full/10.1038/s44318-025-00507-z
2 months ago
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Here is the latest review from the lab on co infections 🥳. Following up on Philipp’s previous work, Philipp and Petr address what is known and all the open questions in this field :
www.embopress.org/doi/full/10....
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Molecular mechanisms of co-infections | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
https://www.embopress.org/doi/full/10.1038/s44319-025-00517-2
2 months ago
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A big congratulations to Dr. Alexandra Boegli for very successfully defending her PhD on listeria activation of the elusive NLRP6! Very well deserved and very well celebrated! 🥳
3 months ago
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Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.
wp.unil.ch/immunobiolog...
7 months ago
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Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳
@dib-unil.bsky.social
@lifesciswitzerland.bsky.social
7 months ago
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Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!
www.biorxiv.org/content/10.1...
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Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells
NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...
https://www.biorxiv.org/content/10.1101/2025.01.23.634286v1?med=mas
8 months ago
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reposted by
Broz Lab
Rebsamen Lab @UNIL
10 months ago
Very happy to share our latest work just published in
@jexpmed.bsky.social
!
#Firstpost
rupress.org/jem/article/...
Our amazing PhD student
@lbernaleau.bsky.social
shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96.
#ImmunoSky
#innateimmunity
#inflammation
Quick summary here:
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CCDC134 controls TLR biogenesis through the ER chaperone Gp96 | Journal of Experimental Medicine | Rockefeller University Press
A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds
https://rupress.org/jem/article/222/3/e20240825/277149/CCDC134-controls-TLR-biogenesis-through-the-ER?searchresult=1
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reposted by
Broz Lab
Inflammasome Lab
10 months ago
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by
#filopodia
to alert
#DendriticCells
they need autopsy. A short Bluetorial (1/13)👇with movies! Link:
rdcu.be/d2mjm
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
https://rdcu.be/d2mjm
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reposted by
Broz Lab
Department of Immunobiology at UNIL
10 months ago
New manuscript by Sina Bohnacker and Julia Esser-von Bieren published in Science Immunology!
www.science.org/doi/10.1126/...
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A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
H. polygyrus glutamate dehydrogenase drives parasite chronicity by epigenetically and metabolically reprogramming host macrophages.
https://www.science.org/doi/10.1126/sciimmunol.adl1467
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reposted by
Broz Lab
Ivan Zanoni
10 months ago
#NoTimeToDie
! @inflammasomelab, Holley, Monteleone &co show
@natimmunol.bsky.social
that cells that die by
#pyroptosis
, or
#necroptosis
, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity!
www.nature.com/articles/s41...
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
https://www.nature.com/articles/s41590-024-02024-3
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First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views,
@elliottbernard.bsky.social
and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here:
rdcu.be/d2nqH
10 months ago
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reposted by
Broz Lab
Natalia Sampaio
10 months ago
I’ve made a Starter Pack of
#innateimmunity
and
#inflammation
researchers to follow! Please contact me to get added or to suggest others to add. We are just getting started 😎
#immunosky
#academicchatter
go.bsky.app/QqJ9AgB
add a skeleton here at some point
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reposted by
Broz Lab
Proteases and Innate immunity lab @ York
10 months ago
go.bsky.app/221DCXf
add a skeleton here at some point
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