Broz Lab
@brozlab.bsky.social
📤 253
📥 129
📝 31
Lab of Petr Broz @ UNIL. Cell death, innate immunology and pathogen defense
Finishing up in snowy Banff with current and former Broz Lab members after the innate immunity symposium.
@jakubbegan.bsky.social
@kaiwenchen-lab.bsky.social
@ehartenian.bsky.social
@keystonesymposia.bsky.social
28 days ago
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reposted by
Broz Lab
Malvina Pizzuto
about 1 month ago
Congratulations to
@jakubegan.bsky.social
,
@brozlab.bsky.social
et al. A nice reminder that lipid acyl chains are not just defining binding interactions. They tune membrane curvature and flexibility, adding an additional layer of regulation to protein activity and cellular signalling
add a skeleton here at some point
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We’re happy to share our updated manuscript on Ninj1, incorporating measurements of membrane tension, cellular assays of ninj1 and ninj2 dimer stability and MD simulations of ninj1 oligmers opening and forming (see below!).
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
about 1 month ago
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We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles
@cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
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Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…
https://www.sciencedirect.com/science/article/pii/S1074761325005734
2 months ago
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Join us for the upcoming innate immunity keystone. There’s a great lineup of speakers.
@keystoneSymposia.bsky.social
#InnateImmunity
: Diversity in
#HostDefense
& Disease, this March!
keysym.us/KSInnateImmune26
#KSInnateImmune26
3 months ago
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Congratulations to (former!) postdoc
@ehartenian.bsky.social
on launching her career with a prestigious
@snf-fns.ch
Ambizione grant at the
@dib-unil.bsky.social
studying how hosts respond to viral infection in her own lab here at the
@dib-unil.bsky.social
!
4 months ago
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9
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reposted by
Broz Lab
Department of Immunobiology at UNIL
4 months ago
Congratulations and welcome to Ella Hartenian
@ehartenian.bsky.social
, who will be launching her group in our Department of Immunobiology in 2026!
www.unil.ch/news/fr/1764...
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Trois récipiendaires Ambizione rejoignent la FBM
Cette année, trois jeunes scientifiques viennent renforcer la Faculté de biologie et de médecine (FBM) de l’Unil. Lauréat·es des subsides Ambizione du Fonds national suisse, Ella Hartenian, David Robe...
https://www.unil.ch/news/fr/1764843092735
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reposted by
Broz Lab
Inflammasome Lab
5 months ago
Join us for an all-star line up for the 2026
#KeystoneSymposia
on
#InnateImmunity
, co-organised by
@jkagan1.bsky.social
&
@brozlab.bsky.social
A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now!
#inflammasomes
,
#TLRs
,
#myeloid
,
#epithelia
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reposted by
Broz Lab
The EMBO Journal
5 months ago
The NLRP6
#inflammasome
is activated by sterile or pathogen-induced endolysosomal damage Petr Broz
@brozlab.bsky.social
and colleagues
www.embopress.org/doi/full/10....
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The week of publications continues for the lab with a
@currentbiology.bsky.social
piece on ninj1 by
@elliottbernard.bsky.social
and
@ehartenian.bsky.social
check it out to have all your pressing ninj1 questions answered :)
www.cell.com/current-biol...
5 months ago
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5
2
reposted by
Broz Lab
Ella Hartenian
5 months ago
Annndddd it’s out! Here’s what came out of combining my virology background with the
@brozlab.bsky.social
’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.
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Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social
@embojournal.org
link.springer.com/article/10.1...
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You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
https://link.springer.com/article/10.1038/s44318-025-00638-3
5 months ago
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November is a big month for the lab with *two* new papers by
@ehartenian.bsky.social
and
@alexandraboegli.bsky.social
++ co authors now online.
www.embopress.org/doi/full/10....
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NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
https://www.embopress.org/doi/full/10.1038/s44319-025-00638-8
5 months ago
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It’s DIB day! The annual conference for our department
@dib-unil.bsky.social
. Lovely day (and view!) at the Lausanne Olympic museum exchanging with our colleagues. Plus a stellar presentation on NINJ1 by our own
@elliottbernard.bsky.social
🔬!
5 months ago
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The second day of the
@dib-unil.bsky.social
#PRR
symposium kicks off with more excellent talks including our own Jakub Began.
7 months ago
0
10
3
reposted by
Broz Lab
Department of Immunobiology at UNIL
7 months ago
Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!
@brozlab.bsky.social
@martinon.bsky.social
@rebsamenlab.bsky.social
@fbm-unil.bsky.social
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reposted by
Broz Lab
Rebsamen Lab @UNIL
7 months ago
Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors! Looking forward to the great programme that we lined up for you together with
@brozlab.bsky.social
@martinon.bsky.social
#ImmunoSky
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reposted by
Broz Lab
Isabella Eckerle
10 months ago
Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine:
jobs.unige.ch/www/wd_porta...
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Professeur-e ordinaire, professeur-e associé-e (6460)
en génomique des maladies infectieuses intracellulaires Chaire dexcellence / Full Professor or Associate Professor in Genomics of Intracellular Infectious Diseases Chair of Excellence
https://jobs.unige.ch/www/wd_portal.show_job?p_web_site_id=1&p_web_page_id=71045
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Congrats to
@malvinapiz.bsky.social
and
@inflammasomelab.bsky.social
on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
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Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...
https://www.embopress.org/doi/full/10.1038/s44318-025-00507-z
9 months ago
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Here is the latest review from the lab on co infections 🥳. Following up on Philipp’s previous work, Philipp and Petr address what is known and all the open questions in this field :
www.embopress.org/doi/full/10....
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Molecular mechanisms of co-infections | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
https://www.embopress.org/doi/full/10.1038/s44319-025-00517-2
9 months ago
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A big congratulations to Dr. Alexandra Boegli for very successfully defending her PhD on listeria activation of the elusive NLRP6! Very well deserved and very well celebrated! 🥳
10 months ago
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Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.
wp.unil.ch/immunobiolog...
about 1 year ago
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Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳
@dib-unil.bsky.social
@lifesciswitzerland.bsky.social
about 1 year ago
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Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!
www.biorxiv.org/content/10.1...
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Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells
NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...
https://www.biorxiv.org/content/10.1101/2025.01.23.634286v1?med=mas
about 1 year ago
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reposted by
Broz Lab
Rebsamen Lab @UNIL
over 1 year ago
Very happy to share our latest work just published in
@jexpmed.bsky.social
!
#Firstpost
rupress.org/jem/article/...
Our amazing PhD student
@lbernaleau.bsky.social
shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96.
#ImmunoSky
#innateimmunity
#inflammation
Quick summary here:
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CCDC134 controls TLR biogenesis through the ER chaperone Gp96 | Journal of Experimental Medicine | Rockefeller University Press
A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds
https://rupress.org/jem/article/222/3/e20240825/277149/CCDC134-controls-TLR-biogenesis-through-the-ER?searchresult=1
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reposted by
Broz Lab
Inflammasome Lab
over 1 year ago
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by
#filopodia
to alert
#DendriticCells
they need autopsy. A short Bluetorial (1/13)👇with movies! Link:
rdcu.be/d2mjm
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
https://rdcu.be/d2mjm
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reposted by
Broz Lab
Department of Immunobiology at UNIL
over 1 year ago
New manuscript by Sina Bohnacker and Julia Esser-von Bieren published in Science Immunology!
www.science.org/doi/10.1126/...
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A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
H. polygyrus glutamate dehydrogenase drives parasite chronicity by epigenetically and metabolically reprogramming host macrophages.
https://www.science.org/doi/10.1126/sciimmunol.adl1467
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reposted by
Broz Lab
Ivan Zanoni
over 1 year ago
#NoTimeToDie
! @inflammasomelab, Holley, Monteleone &co show
@natimmunol.bsky.social
that cells that die by
#pyroptosis
, or
#necroptosis
, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity!
www.nature.com/articles/s41...
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
https://www.nature.com/articles/s41590-024-02024-3
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First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views,
@elliottbernard.bsky.social
and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here:
rdcu.be/d2nqH
over 1 year ago
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reposted by
Broz Lab
Natalia Sampaio
over 1 year ago
I’ve made a Starter Pack of
#innateimmunity
and
#inflammation
researchers to follow! Please contact me to get added or to suggest others to add. We are just getting started 😎
#immunosky
#academicchatter
go.bsky.app/QqJ9AgB
add a skeleton here at some point
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reposted by
Broz Lab
Proteases and Innate immunity lab @ York
over 1 year ago
go.bsky.app/221DCXf
add a skeleton here at some point
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