Kaiwen Chen
@kaiwenchen-lab.bsky.social
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Assistant Professor in NUS Singapore. Cell death, innate immunity and host-pathogen interaction.
pinned post!
I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats
@michelleyeaphw.bsky.social
and all co-authors! 🥳
www.embopress.org/doi/full/10....
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection | The EMBO Journal
imageimageHost cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. Th...
https://www.embopress.org/doi/full/10.1038/s44318-025-00412-5
about 1 year ago
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I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats
@michelleyeaphw.bsky.social
and all co-authors! 🥳
www.embopress.org/doi/full/10....
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection | The EMBO Journal
imageimageHost cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. Th...
https://www.embopress.org/doi/full/10.1038/s44318-025-00412-5
about 1 year ago
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reposted by
Kaiwen Chen
JelenaBezbradicaLab
about 1 year ago
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org/doi/10.1126/...
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TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
https://www.science.org/doi/10.1126/sciadv.adq1047
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Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive.
www.cell.com/cell-reports...
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Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01567-5
about 1 year ago
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reposted by
Kaiwen Chen
Mike Lee
over 1 year ago
We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n):
www.biorxiv.org/content/10.1...
🧪
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Pol II degradation activates cell death independently from the loss of transcription
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...
https://www.biorxiv.org/content/10.1101/2024.12.09.627542v1
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reposted by
Kaiwen Chen
Kat Mayer-Barber,PhD
over 1 year ago
Best
#Nikolaus
🎅! Our paper on how the 🫁 microenvironment can shape
#innate
immunity against
#viruses
is out
@sciimmunology.bsky.social
This was a herculean effort brilliantly led by
@pauljbaker.bsky.social
who singlehandedly established the model in the lab during the pandemic. 🧪
#Immunosky
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reposted by
Kaiwen Chen
Inflammasome Lab
over 1 year ago
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by
#filopodia
to alert
#DendriticCells
they need autopsy. A short Bluetorial (1/13)👇with movies! Link:
rdcu.be/d2mjm
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
https://rdcu.be/d2mjm
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reposted by
Kaiwen Chen
Ivan Zanoni
over 1 year ago
#NoTimeToDie
! @inflammasomelab, Holley, Monteleone &co show
@natimmunol.bsky.social
that cells that die by
#pyroptosis
, or
#necroptosis
, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity!
www.nature.com/articles/s41...
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
https://www.nature.com/articles/s41590-024-02024-3
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reposted by
Kaiwen Chen
Jacki Heraud-Farlow
over 1 year ago
Thrilled to share our new paper out today in
#ScienceImmunology
! It’s been a long time coming and I’m so excited to be able to share it. Skeetorial (is that what we call it here?) to come when it is (a) not Saturday and (b) not my birthday. Best present ever!
#ImmunoSky
#RNASky
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GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.
https://www.science.org/doi/10.1126/sciimmunol.adk0412
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