Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc! authors.elsevier.com/a/1ly0C3vVUP...

Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology! #Immunology #NatureSMB #Inflammasomes rdcu.be/eG1Nm

Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org

Who wants to discuss innate immunity and host defense? Join us in Banff to share your exciting research. www.keystonesymposia.org/conferences/...

New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story. www.biorxiv.org/content/10.1...

Review @cp-molcell.bsky.social @inflammasomelab.bsky.social NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress www.cell.com/molecular-ce...

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open! Recognising an ECR who’s advanced the Australasian cell death community. 🏆 Winner gets a cash prize, medal & invited talk. Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ... So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵 This is a repost from X because you all need to know! #NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience @nhmrc.bsky.social

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps go.nature.com/4pxKgV6

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/... #Inflammasome #Inflammation

🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ). A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.

🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social‬, ‪@rosemaryjcater.bsky.social‬. @kmichie.bsky.social‬. 1/n

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

🚨It’s out @embojournal.org 🚨 Cardiolipin inhibits Caspase-4/11! Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project www.embopress.org/doi/full/10....

A joy of the job is sharing moments like this after years of working together. May I present Dr Julian Radford-Smith @jradford-smith.bsky.social, with special guests Barbara and Rosalind. Photos taken by the wonderful @lilydun.bsky.social

Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!

Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇

In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access) www.science.org/doi/10.1126/...

The Hunter Meeting has made it to the blue place! 🔵 If you are joining us in the beautiful #HunterValley 2-5 June 2025 - please tag us or search #HunterMeetingOz to follow along. #STEM #CellBiology #DevBio #SpatialOmics @anzscdb.bsky.social #AustralianMeeting

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award! A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️ Conference? Lab visit? Data training? This one's for you. More info below

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW

Congratulations @v-hornung.bsky.social! Richly deserved. Wonderful to see another inflammasome great amongst the awardees!

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

Studies of researchers globally suggest there is a mental-health crisis in academia https://go.nature.com/3RNAbmZ

Big congrats to one of our @wehi-research.bsky.social stars, @someblondesci.bsky.social !

'Curiosity-driven research' led to a recent major medical breakthrough. But it's under threat - The Conversation AU

Nature research paper: A natural experiment on the effect of herpes zoster vaccination on dementia https://go.nature.com/3XHRhq5

NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health. grants.nih.gov/grants/guide...

These guys inherited one of the most functional state apparatus in the history of the world and they are inhabiting it like a crack house. www.theatlantic.com/politics/arc...

Excellent article #auspol www.abc.net.au/news/2025-03...

The next exciting instalment from @jradford-smith.bsky.social on how climate filters rainforest tree strategies in the Australian subtropics. Now available in early view at @ecography.bsky.social doi.org/10.1111/ecog...

OMG

(5/5) Discover more about what ACDS offers australasiancelldeathsociety.com, from a detailed cell death researcher directory to engaging discussion sessions. Join our community and be part of the next wave of medical advances . 🌊

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

(1/5) Hello, Bluesky community! We're thrilled to be here. 🌟 We are the ACDS, your hub for connecting cell death researchers across Australasia and beyond. We're here to foster a community that embodies scientific integrity, collaboration and communicates science across the globe!

I Used to Run the N.I.H. Here’s What Worries Me. “members of the executive and legislative branches have long seen themselves as caretakers of a precious commodity — the nation’s scientific and technological communities. Today is very different.” www.nytimes.com/2025/02/14/o...

Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance www.pnas.org/doi/10.1073/...

This is what journals need to be doing: ignoring orders to self-censor and celebrating and uplifting a diverse scientific workforce

summary of where we stand at the moment www.science.org/content/blog...

Applications for undergraduate summer studentships @wwiem-qub.bsky.social are now open. We would love to host enthusiastic students from anywhere in the world in Belfast! 👨‍🔬👩‍🔬🧪💊🌎 Details: www.qub.ac.uk/research-cen...

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

Excited to share our latest paper out today in @naturecomms.bsky.social ! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #ImmunoSky #InterferoSky