Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.

Locals in Adelaide are now in full bloom 😊

Very cool study: LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

www.nature.com/articles/s41... New publication from our lab.

Shades of Spring in Adelaide: frost and Sakura 😊

🧬 New paper alert! @molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports. erictopol.substack.com/p/new-anti-a...

An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming https://go.nature.com/43lhNbO

Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals https://go.nature.com/3EpQfIA

Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com www.nature.com/articles/s41...

Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia https://go.nature.com/4j2WTDZ

Studies of researchers globally suggest there is a mental-health crisis in academia https://go.nature.com/3RNAbmZ

“I’ve never thought that this would be accomplished in my lifetime” Researchers have successfully sequenced the complete genomes of six ape species https://go.nature.com/4j9jE9k

Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue https://go.nature.com/4cu68dN

Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social

Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...

Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration Are you thinking about leaving? https://go.nature.com/4bMGd0J

The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. www.science.org/doi/10.1126/...

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition? www.nature.com/articles/s41... High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com

next Canadian government should think of boosting research funding up here and trying to grab as many American postdocs and researchers as possible

Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC https://go.nature.com/41IPJwX

Australia: Shergold says ARC funding scheme redesign should set the course for decades ahead (free to read): www.researchprofessionalnews.com/rr-news-aust...

“NIH-funded research contributed to 354 of 356 drugs approved by the US Food and Drug Administration in 2010–19.”

Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally https://go.nature.com/3FbZP1N

(1/5) Hello, Bluesky community! We're thrilled to be here. 🌟 We are the ACDS, your hub for connecting cell death researchers across Australasia and beyond. We're here to foster a community that embodies scientific integrity, collaboration and communicates science across the globe!

GLP-1 drugs association with reduced risk of blood cancers (leukemias and lymphomas) jamanetwork.com/journals/jam...

PIEZO2 ion channels come to the fore yet again, now as a key sensor for adipose tissue www.cell.com/cell-metabol... @ardemp.bskyverified.social @scripps.edu

Review @natrevimmunol.bsky.social New insights into the noncanonical inflammasome point to caspase-4 as a druggable target www.nature.com/articles/s41...

Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in MASH www.nature.com/articles/s41...

Interesting work! Norovirus co-opts NINJ1 for selective protein secretion | Science Advances www.science.org/doi/10.1126/...

Nature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses https://go.nature.com/3XmyOPD

Yeah. They should release a 20 page proposal tomorrow that has "WE NEED MORE MONEY" printed on every single page and nothing else.

Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer https://go.nature.com/41qNkbs

Really cool study showing that EVs shed from pyroptotic cells contain gasdermin pores that, when fused to other cells, cause bystander cell death. Transplantation of gasdermin pores by extracellular vesicles propagate... sciencedirect.com/science/articl…

BREAKING: Scientists are bracing for major changes in the direction of US biomedical research as Robert F. Kennedy Jr, who has promoted vaccine misinformation and public-health conspiracies, gains control over a vast swathe of science policy. https://go.nature.com/4hYQEQj

Nature research paper: Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations https://go.nature.com/3WZ9ije

Texas measles outbreak doubled, now into 4 counties www.houstonchronicle.com/health/artic...

Major U.S. health agencies, including the NIH and the CDC, are firing thousands of probationary employees this afternoon. Follow Science’s coverage of President Donald Trump’s impact on U.S. research and science globally. ⬇️ scim.ag/40XtSSi

I Used to Run the N.I.H. Here’s What Worries Me. www.nytimes.com/2025/02/14/o...

I Used to Run the N.I.H. Here’s What Worries Me. “members of the executive and legislative branches have long seen themselves as caretakers of a precious commodity — the nation’s scientific and technological communities. Today is very different.” www.nytimes.com/2025/02/14/o...

A shining example....there are 1,000s of these fundamental science discoveries that NIH supports to promote human health

Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...

Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...

New data coming out of CDC (despite ban on communication) on respiratory virus status; confirms past-peak for Covid, RSV www.cdc.gov/respiratory-...

I've stopped posting on Twitter and Threads. I'll stop interacting there and lock those accounts at the end of the week. If you have colleagues who used to follow me on those platforms, feel free to let them know, and that they can follow me here or Mastodon instead. 🙏

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

Important Covid editorial @science.org by Maria Van Kerkhove www.science.org/doi/10.1126/...