Check out this new thermo-hot paper from the @colllab.bsky.social Lab. Glad to contribute and work with her team. www.biorxiv.org/content/10.1...

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

Nice to see our recent study on novel NLRP3 inhibitors with Bioage Labs in @jem.org highlighted by @natrevdrugdiscov.nature.com - 🔦💊🔥 😍 Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors nature.com/articles/d41...

@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/... #Inflammasome

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/... #Inflammasome #Inflammation

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Had a brilliant couple of days in Galway with the lab at the Irish Society for Immunology meeting - great science and great craic!!!

Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...

Congratulations to our latest cohort of summer students @WWIEM @qubelfastofficial.bsky.social for a fantastic final poster session - the standard was exceptionally high. Special shout out to Timothy Okafor who was a pleasure to host in my lab!!

Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

Paper accepted!!!

Huge congratulations to the new Dr Thea Mawhinney!! Thank you to her fantastic examiners Prof Suzanne Cloonan @suzcloo.bsky.social and Prof Cliff Taggart @wwiem-qub.bsky.social

Cockatoos have learned to operate drinking fountains in Australia. The behavior—never before seen in birds—may be a developing cultural tradition among one population: scim.ag/4kIi12G

I'm delighted to be hosting a #NLRP3 InflammaZoom spectacular next week! With Alex Weber and Ana Tapia Abellan - please join us on Monday 19th May. Register here: events.abcam.com/event/Inflam...

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!

You've got to love the Irish enthusiasm for a bit of good weather 16°C=summertime 😎

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare - any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

Brilliant and elegant work from @jelenalab.bsky.social - showing yet again the complexity of how our immune system keeps itself in check!!

Queen's University Belfast has launched it's call for MSCA postdoctoral fellowship applications - if anyone would like to discuss submitting a project please get in touch! #MCSA @wwiem-qub.bsky.social www.qub.ac.uk/Research/our...

'New insights into the noncanonical inflammasome point to caspase-4 as a druggable target' Progress article by Elad Elkayam, Francois Gervais, Hao Wu, Michael Crackower & Judy Lieberman @harvardmed.bsky.social @bostonchildrens.bsky.social #inflammasome #immunology #immunosky

Last few days to apply for our summer online student programme - iENGAGE 2025 Join us for 6 weeks this summer, working with our researchers and gaining valuable experience on research across our areas of expertise Apply now here: www.qub.ac.uk/research-cen...

📢 Calling all female African scientists. Applications open for the EMBL-UNESCO 3-month residencies in infection biology: 🪴 Grow your network 🧪Develop your skills 🧠Exchange knowledge with international colleagues Deadline: 31 March 2025 www.embl.org/about/info/s... #WomenInSTEM #WomenInScience

Yet another assault on scientists everywhere by the NYT today - when will it stop?! #spellingbee 🐝

Invest in your potential with our Career Enhancing Grants 🙌 These grants are here to support you in navigating the world of #immunology and reaching new heights in your #career 🚀 Apply now! bit.ly/3QedNDL Deadline: 27 March

Applications for undergraduate summer studentships @wwiem-qub.bsky.social are now open. We would love to host enthusiastic students from anywhere in the world in Belfast! 👨‍🔬👩‍🔬🧪💊🌎 Details: www.qub.ac.uk/research-cen...

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...

Would love to talk to ECRs who might be interested in applying for a post-doctoral fellowship to study human inflammasomes! The Royal Society Newton International Fellowships are open to anyone outside the UK. More details in the post below

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...

Ok so about 20 years ago or so I was actually in a band called the Meatles, the world's first meat-themed Beatles covers band. We did songs like I Want To Hold Your Ham and Let It Beef and She's Got A Chicken To Fry. Probably only ever did five or six gigs but it was a lot of fun.

I was today years old when I learned that Asparagine the first ever amino acid to be isolated and it was from... Asparagus #doh #nonessential information

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼

I'm dead...this is like a real anime on @netflix.com! www.netflix.com/au/title/810...

So excited to have our new paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3 #innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek. www.nature.com/articles/s41...

40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

Stop Forcing A.I. into Fucking EVERYTHING!

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action https://www.biorxiv.org/content/10.1101/2024.12.21.629867v1

President Higgins' final Christmas message - well worth a watch 🎄♥️

Our Editors’ Choice of articles published in #Science #Immunology this year is out now! This free sample collection will be available online to read until the end of February 2025! bit.ly/SciImm_free

Very happy that our team "Deck the Colls" won the annual Christmas table quiz (again!) @wwiem-qub.bsky.social thanks to quizmaster extraordinaire @shemandshaun.bsky.social 🎄🍾

A lovely celebration of all the @wwiem-qub.bsky.social PhD and MSc graduates today. Congrats to everyone and especially to our dapper MSc student (now PhD candidate) Thomas! 🎉🎄🍾

You wanted starter packs to be searchable. Our engineers are busy keeping us online, so in the meantime, an independent developer built a new searchable library of starter packs. This is the beauty of building in the open 🦋

For a number of years now, I’ve had a policy that I don’t submit to nor will I review for MPDI and Frontiers. This analysis supports that decision. It’s no reflection on the many excellent papers and studies that have been published in them, but rather on their editorial and business practices.

Here are the Science family journal editors currently on Bluesky, including the whole Science Immunology crew! 🧪 go.bsky.app/CQytTHw

Had the privilege of hosting Prof Botond Roska from the IOB at WWIEM QUB to deliver the 2024 Barcroft medal lecture today - his talk on using optogenetic therapies to restore vision was incredibly inspiring!! 👀 💉👓💚

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...