Belated post of my macaron centrepiece from last week’s @ciiid-hudson.bsky.social Christmas party – “the cells of CiiiD”. A lot of work to produce this undetermined number of macarons (I lost count) 🙃 Big thanks to @biorender.bsky.social who I used to make the templates! @hudsonresearch.bsky.social

Never expected to be mentioned in the Nature Briefing www.nature.com/immersive/d4...

Congrats @lauracanaday.bsky.social @andypedsid.bsky.social @hafeldman17.bsky.social & team on our newest publication @jimmunol.bsky.social Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection academic.oup.com/jimmunol/adv...

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

One month left until early registration closes! Apply now if you would like to be considered for a talk. It will be an amazing conference bringing together leading scientists in the field of protein design. [Protein Emoji]

NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study. www.nature.com/articles/s41... @ivahb.bsky.social @elvirab.bsky.social

Subcellular location of NLRP3 is not essential, but clustering on different scaffolds is. This explains how NLRP3 can react to so many diverse stress signals. 9/9

Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in @natcomms.nature.com: nature.com/articles/s41... See 🧵👇 1/9

Check out Elvira's explanation of the freshly published study below...

Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social www.nature.com/articles/s41...

Two-dozen billion-dollar U.S. startups were founded by foreign students who studied at Harvard --Axios. Making America Poor Again Making America Dumb Again

Just like we need women in STEM and "Girls Who Code", we need “Men Who Nurse” and “Guys Who Teach,” pipeline programs that can offer boys pathways forward in female-typed fields. @reshmasaujani.bsky.social time.com/7286184/worr...

Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids pubmed.ncbi.nlm.nih.gov/40140423/ #cryoem

Exciting times ahead! Kicking off our new EIC Pathfinder project SCALPEL: www.linkedin.com/posts/scalpe...

Congratulations to the Unesco L'Oreal For Women in Science (Slovenia) Awardees! siol.net/novice/digis...

Damon Runyon Cancer Research Foundation awards $4.4M to top young scientists www.damonrunyon.org/news/entries...

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

This administration is taking a blowtorch to the entire education path from early childhood programs to undergrad universities to higher ed as we look on. Any US company/institution that relies on a well-educated workforce is going to lose its competitive edge. This is a ⏰⏰⏰⏰🔥🔥national crisis

Excited to join bsky.social! 🌟 Our latest study, on the cover of @embopress.org , shows platelets transfer transcription factor (NF-κB, p38) signaling to monocytes, licensing monocyte inflammation, and restoring monocyte dysfunction in autoimmune Thrombocytopenia. www.embopress.org/doi/full/10....

Researchers at the National Institute of Chemistry have developed a novel therapeutic strategy called cytokine-armed pyroptosis. The study, published in @naturecomms.bsky.social , will be presented by first author Sara Orehek on January 23, 2025, at the Forum 40 lecture series. bit.ly/4ho2e7m

Check this video where he Head of the #CTGCT prof. dr. Mojca Benčina appeared in the news of the Slovenian national TV as one of the breakthrough discoveries by Slovenian scientists in 2024. lnkd.in/dtx6VyNT #research #ultrasound #innovation #cellandgentherapy

Researchers (from @ivahb.bsky.social's group and #CTGCT) developed a way to enhance the immune system's ability to combat cancer combining pyroptosis, with specific cytokines that boost immune activity. www.nature.com/articles/s41... #CancerResearch #Immunotherapy #Innovation #Science

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek. www.nature.com/articles/s41...

Such a great opportunity! I took this course in grad school in 2001. It was transformative for my thinking and led to some lifelong friendships. Highly recommend!

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...