Many congratulations Emma for your Ph.D.📜 Remarkable contribution to the NLRP3 inflammasome field 👩‍🔬

So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊

#ChronicPain is considered one of the leading causes of disability worldwide. But for the first time, researchers at @CMD.ox.ac.uk and others have discovered a new genetic link to pain, offering a promising target for treating chronic pain 🧬 Find out more 👉 www.ndm.ox.ac.uk/news/chronic...

Our review is out now in Molecular & Cellular Proteomics! We discuss the latest advances in #HDX mass spectrometry to aid neurotherapeutic design & development in #Alzheimers, #Parkinsons and #ALS, providing molecular insights into protein aggregation pathways and therapeutic antibodies 🧠

🗺️ Interactive Map Update! 2 new UK-based labs have been added to the global TPD map: 🔹 Kessler Lab @kesslerbenedikt001.bsky.social 🔹 Fletcher Lab Explore these and many other TPD and ubiquitin labs: 👉 tpd-community.com #TPD #ProteinDegradation #Ubiquitin

My time in his lab - which only stretched 6-7 months - has had a lasting impact on my career. It was there, that I fell in love with proteases, I met my later post-doc advisor @mbogyo.bsky.social, performed my first cell culture under guidance of @kesslerbenedikt001.bsky.social, and learned a lot!

Last Saturday, I attended - unfortunately not live, but hybrid - the retirement symposium of Prof. Hidde Ploegh. I enjoyed presentations of @kesslerbenedikt001.bsky.social @mbogyo.bsky.social, Domenic Tortorella, various other alumni of the lab, and of course of Hidde himself

Integrative proximal-ubiquitomics profiling for deubiquitinase (DUB) substrate discovery applied to USP30: www.cell.com/cell-chemica...

ABPP reveals novel ubiquitin pathway enzymes in Plasmodium. PLOS Pathogens 21(4): e1013032. doi.org/10.1371/jour... & Katerina Artanavis-Tsakonas’ lab

Also see the associated News & Views by Tim Clausen for a quick summary: www.nature.com/articles/d41...

Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions! 👉 go.nature.com/43k1a0H

DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...

Profiling E2-specific substrates reveals tyrosine ubiquitination rdcu.be/eax1F News & Views rdcu.be/eaw41

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Interesting talk by Hannah Jones at #EFMCISBC25. She talked at the development of a chemoproteomic assay with data-independent acquisition to profile deubiquitinase binders at 100 samples per day with a coverage of 35-40 DUBs. www.mdpi.com/1422-0067/23...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination www.nature.com/articles/s41...

From the Kessler Lab & STAMP @darraghobrien.bsky.social: Structural Dynamics of the Ubiquitin Specific Protease USP30-Inhibitor Complex revealed by HDX-MS @cmd.ox.ac.uk shorturl.at/GeImS

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn