Michael Gantier
@gantierlab.bsky.social
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Research group at Hudson Institute of Medical Res. - Nucleic acids innate immunity
reposted by
Michael Gantier
3 days ago
How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with
@gantierlab.bsky.social
shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐
www.nature.com/articles/s41590-026-02429-2
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2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature Immunology
Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.
https://www.nature.com/articles/s41590-026-02429-2
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I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. >
www.nature.com/articles/s41...
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2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity | Nature Immunology
https://www.nature.com/articles/s41590-026-02429-2
3 days ago
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www.linkedin.com/posts/mrna-v...
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#mrna #lupusawarenessmonth #mrnaresearch #innovation #biotechnology #victorianhealthcare #medicalresearch #mrnavictoria | mRNA Victoria
New hope for 20,000 Australians living with lupus 🧬 October is Lupus Awareness Month, and there's exciting progress in the fight against this debilitating autoimmune disease. Researcher Michael Ga...
https://www.linkedin.com/posts/mrna-victoria_mrna-lupusawarenessmonth-mrnaresearch-ugcPost-7389422772931850240-Ct0e?utm_source=share
4 months ago
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reposted by
Michael Gantier
Molecular Therapy Family of Journals
8 months ago
#MTNA
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IsomiR stoichiometry changes as disease biomarkers.
Gantier, Gearing and colleagues demonstrate, through analysis of small RNA sequencing data, that quantification of microRNA isoforms enables identification of accurate biomarker candidates overlooked in aggregated microRNA data. A ratio-based approach to isoform-level biomarker discovery is presented, measuring the relative abundance of alternate isoforms to provide internal normalisation within a microRNA.
http://dlvr.it/TLDY4b
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Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this!
doi.org/10.1016/j.om...
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https://doi.org/10.1016/j.omtn.2025.102578
8 months ago
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reposted by
Michael Gantier
International Cytokine & Interferon Society (ICIS)
11 months ago
Co-Chairs, Michael Gale, Jr. and
@ramlabuw.bsky.social
invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit:
seattle.cytokinesociety.org/call-for-abs...
Deadline is May 18, 2025.
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For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at
www.rnavic.com
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RNA Victoria minisymposium | RNA Victoria Network
https://www.rnavic.com/
12 months ago
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reposted by
Michael Gantier
Journal of Experimental Medicine
about 1 year ago
Gomez-Diaz,
@v-hornung.bsky.social
et al. show that mice lacking RNase T2 display an inflammatory phenotype in a TLR13-dependent manner, even under germ-free conditions, suggesting that RNase T2 plays an important role in limiting self-RNA recognition
https://buff.ly/4jG49Gy
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