Ever wondered what happens to oligonucleotide therapeutics once they start to break down? In our new bioRxiv preprint, we provide a molecular dissection of how chemically modified 3‑base oligonucleotide fragments engage TLR7 and TLR8. Check it out! www.biorxiv.org/content/10.6...

Dear fellow nucleic acid immunity researchers, registrations and poster submissions for the 3rd annual meeting of the international society of nucleic acid immunity in Nara, Japan (Sept 16-18th) are now open. Abstract Submission Deadline: June 12, 2026-See you there! www.ifrec.osaka-u.ac.jp/nais26/

A great summary about our recent Nature Immunology paper on TLR7/8 natural antagonism, thanks to Maialen Sebastian-delaCruz! New Checkpoint in TLR7/8 Sensing Rewrites Innate Immune Rules signals.cytokinesociety.org/2026/03/14/g...

The implications are profound, and go beyond TLR7/8: TLR9 uses the same basic design to discriminate self/nonself DNA. Together, TLR7/8/9 must be the key system to distinguish between retroviral particles and normal exosomes: evolution HAD to come up with a way to do this.

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ www.nature.com/articles/s41590-026-02429-2

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...

Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this! doi.org/10.1016/j.om...

Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs... Deadline is May 18, 2025.

For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at www.rnavic.com

Gomez-Diaz, @v-hornung.bsky.social et al. show that mice lacking RNase T2 display an inflammatory phenotype in a TLR13-dependent manner, even under germ-free conditions, suggesting that RNase T2 plays an important role in limiting self-RNA recognition https://buff.ly/4jG49Gy