New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story. www.biorxiv.org/content/10.1...

🔔 Chech out this new cool story on non-canonical inflammasome signaling in NK cells by @protinnimmunity.bsky.social

Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase.bsky.social from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!

🔔 Join us this Tuesday on how to maximize AI for your research 🔬 🧬 insights from three outstanding scientists. more info‘s see 👇

📢 Join us for the 2025 Australian Inflammation Centres (AIC) Symposium in Adelaide, 10–11 Nov! Featuring top speakers — including Prof. David Huang — and great opportunities for early/mid-career researchers to connect and collaborate. 🧬 Free registration + online option available!

Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps go.nature.com/4pxKgV6

🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ). A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Happening today! In 6.5hrs 🌏

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

⏰ Reminder: just 1 week to go until the next International Cell Death Seminar (3 Sept)! Don’t miss this global line-up of speakers 🌍🧬

check out our 2nd International Cell death seminar coming up in two weeks ‼️ @auscelldeathsoc.bsky.social and @ecdoorg.bsky.social More information👇 Sign up the become an ACDS member - it’s free 🔔

🚨 Don’t miss our joint ACSD–ECDO-CDDpress webinar on the exciting science of cell death! 🔬 Featuring top speakers: Grant Dewsonn Caroline Holley, Uris Ros and Alessandro Annibaldi. Cutting-edge talks + inspiring discussions await! ✨

10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...

Friendliness isn't always a sign of trustworthiness. Warmth is easy to fake. The foundations of trust are reliability and integrity. What counts isn't courtesy in the moment—it's keeping commitments over time. The best way to inspire confidence is to consistently walk our talk.

🧬 New paper alert! Former ACDS committee member Dr Malvina & team identify mitochondrial cardiolipin as a selective inhibitor of CASP4/11-driven cell death & inflammation @inflammasomelab.bsky.social 📄 Read here: www.embopress.org/doi/full/10....

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project www.embopress.org/doi/full/10....

It was a great pleasure having you with us Daniel and thank you for sharing your amazing work on myddosome! ☺️🤩

Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇

Register for our upcoming 30 min webinar In the Lab with Dr Sabrina Burgener - Live cell imaging of Inflammasome signalling. us02web.zoom.us/webinar/regi... @s-burgener.bsky.social #CellDeath #NLRP3 #Inflammasome #CellAnalysis #InTheLabWebinar

It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇

Metabolic dysfunction-associated steatohepatitis (MASH) drives rising morbidity and mortality, yet remains underdiagnosed. A new Health Policy paper by ‪@jvlazarus.bsky.social‬ and colleagues calls for community-based diagnostics: shorturl.at/a0COQ #LiverSky #SLDthinktank

Deadline is THIS Friday 🚨 ‼️ 🔔 Still time to apply - don’t miss it All information below 👇

Join us at next month ACDS seminar with two fantastic speakers 🤩

⏳ Time’s ticking! Applications for the 2025 ACDS Professional Development Award are closing soon! 💰 $2,000 available to support your next big step—conference, training, or research visit! 🗓️ Deadline: Friday 6 June, 5pm AEST 🔗 Apply now!

‼️ Plan to attend an international conference on Cell death 💀 this year or beginning of next year - here is your chance to win a travel award - see details below👇 still one week left to apply!

Today, in #preprinthub2 Raisa Brito @mdc-berlin.bsky.social will present a #preprint from @inflammasomelab.bsky.social on how caspase-1 self-terminates protease activity to enforce homeostasis and prevent #inflammasome driven diseases. ✂️🧯🐭 #immunosky www.biorxiv.org/content/10.1...

What a fantastic seminar; many thanks to the four fantastic speakers presenting their amazing work on cell death!!! Next one is coming in September - can’t wait ☺️

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award! A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️ Conference? Lab visit? Data training? This one's for you. More info below

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW

We love to know how our favorite immune pathway gets activated; here we simply ask how does it get inactivated - and if so is Casp1 regulating its own deactivation? Curious to see the answer; check out our preprint of a multidisciplinary and collaborative approach to untackle Casp1 activity in vivo!

T-1 week! Cell death enthusiasts across the globe, make sure this one is in your calendar! 🍂

🗓️ Just 2 weeks to go! Don't miss our International Cell Death Seminar Series in collaboration with @ecdoorg.bsky.social & @CDDpress! 📅 Wed 7 May | 🕓 4:30pm AEST / 8:30am CEST 📍 Online – Zoom link in the poster Incredible global speakers lined up—mark your calendars! 🔬🌍

...and here we are! 🎉 ECDO has officially joined the Bsky community! Here, we will share the latest news, events, and publications from the ECDO network. 🧬✨ Stay tuned !!!! #ECDO #CellDeathResearch #BLSK #ScientificCollaboration #CellBiology #TranslationalResearch #NewBeginnings

Excited to share that our collaborative work on PLpro inhibitors is published! Using a model that replicates symptoms seen in long COVID patients, we show that a potent antiviral can prevent long-term disease. A big step forward in long COVID therapy. #LongCOVID #PLpro #COVID19 #SARSCoV2 #Antivirals

(1/3) 🌍 We're kicking off our 2025 International Cell Death Seminar Series with @ecdo & @CDDpress on Wed 7 May! 🕓 4:30pm AEST / 8:30am CEST 📍 Online (Zoom link in poster) A fantastic international line-up awaits... 🧵👇

Follow us 👇 and if you haven’t signed up join our society for free! Don’t miss out on some cool cell death events in 2025; 🔔 stay tune for coming up announcements 💀

See below a unique opportunity for an excellent PhD position with a fantastic scientist as a mentor!!!!

A fantastic morning hosting 2 exceptional #celldeath researchers at the 2025 #ACDS Welcome Seminar! Seth Masters shared his exciting research program exploring NLRP mutations in patients with inflammatory disease. Similarly, Aysha Al-Ani showed us the power of combining bedside-bench IBD research 🔥

Don't confuse being a fast talker with being a deep thinker. Speaking quickly signals confidence, not complexity. Don't mistake volume for expertise. Speaking loudly reflects conviction, not credibility. Sometimes the best ideas come from the least assertive voice in the room.

Australian Cell Death Society ACDS offers an a Mentoring program! World’s most stellar cell death scientists offer to share all their tricks and tips! Sign up today ☠️ check out: australasiancelldeathsociety.com

Lunch is the most important part of my day in the lab; it’s the time when you connect with others!! Don’t need to be the busy scientists; lunch to your peers and lab members is so valuable! It doesn’t matter how busy your day is; stop what you are doing and have a break and enjoy a meal together!

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...