Jakub Began (@jakubegan.bsky.social)

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

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Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr... https://www.cell.com/immunity/fulltext/S1074-7613(25)00573-4