Jakub Began
@jakubegan.bsky.social
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Protein biochemist, hiker, floorball player
reposted by
Jakub Began
25 days ago
Excited to share this paper from
@yiechanglin.bsky.social
showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟
#MDsimulations
#StructuralBiology
doi.org/10.1016/j.bp...
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In Lausanne, we have an incredible environment for research, and our immunology hub is truly thriving! I’m proud to be part of it 👇
add a skeleton here at some point
about 2 months ago
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reposted by
Jakub Began
Broz Lab
3 months ago
Finishing up in snowy Banff with current and former Broz Lab members after the innate immunity symposium.
@jakubbegan.bsky.social
@kaiwenchen-lab.bsky.social
@ehartenian.bsky.social
@keystonesymposia.bsky.social
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PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity.
www.cell.com/immunity/ful...
I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇
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Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00573-4
4 months ago
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