New JCS snapshot - Cytotoxic T lymphocytes adapt to the loss of Cdc42 @adamrochussen.bsky.social presents the key findings from their recent JCS paper with Claire Ma and Gillian Griffiths @griffithslab.bsky.social. journals.biologists.com/jcs/article/...

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ... In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

As promised at my seminar at NCBS, here is the video showing what happens to the centrosome in a “confused T cell” that is contacting two targets with equal signals.

Welcome to the dynamic world of T cells!