Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3 www.science.org/doi/full/10....

Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀 & this year was @keisakamoto.bsky.social personal best 🙌🍾

Stoked to be one of the recipients of the EFSD/Lilly Young Investigator Award for my project where I will investigate the role of impaired glycogenolysis &/or aberrant glycogen in glucose homeostasis! Thanks to @easdnews.bsky.social for the funding. www.europeandiabetesfoundation.org/recipients/e...

Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science www.europeandiabetesfoundation.org/recipients/e...

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science www.nature.com/articles/s41...

Happy to share my article as part of the Journal Club series in @natrevendo.nature.com where I discuss about the emerging role of #glycogen #metabolism as an important #signaling molecule regulating energy homeostasis in adipose tissue. nature.com/articles/s4157…

Impaired #glycogen metabolism in the #brain is associated with tauopathies, like #Alzheimers

Frailty poses a major public health challenge, yet it is a poorly understood condition globally. To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission. Find out more ▶️ tinyurl.com/4zhkvt89

Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for guiding our junior colleagues. We wish her the best for her bright future! .

Last year in #ScienceRobotics, researchers followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit. Learn more: scim.ag/46hifcU #ScienceMagArchives

🚨 We have two vacancies for PhD fellows: - on ideological stereotypes supervised by me and @robindevroe.bsky.social www.ugent.be/en/work/scie... - on losers' consent supervised by @annakern.bsky.social www.ugent.be/en/work/scie... Join research group @gasparugent.bsky.social in beautiful Ghent

Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.

Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome. Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1

The wonders that Basic science funding can lead to! What an achievement 👏

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday www.pnas.org/doi/10.1073/...

“Science has no passport, no gender, no ethnicity, no political party.” EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent. In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.

Towards optimizing #cancer therapy through a #microbiota lens @naturemetabolism.bsky.social www.nature.com/articles/s42...

The expanding evidence base and new molecules in the new world of GLP-1 medicines. Beyond #T2D #obesity @naturerevdrugdisc.bsky.social can01.safelinks.protection.outlook.com?url=https%3A...

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.

The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO

The compounding of GLP-1 medicines, safety and efficacy, has been contentious. The courts are starting to opine #weightloss #obesity www.cnbc.com/amp/2025/04/...

More evidence that hepatocyte gluconeogenic gene expression and glucose production are spatially and temporally plastic across the liver lobule, underscoring complexity of defining hepatic insulin resistance and glucose production on a whole-organ level www.nature.com/articles/s42...

Comprehensive review on the regulation of glucose and fructose metabolism from the @svenssonlab.bsky.social @annualreviews.bsky.social

“This study is a landmark contribution to understanding mpox dynamics and guiding proactive prevention efforts across Africa and beyond.” scim.ag/4cvor2m

Dysregulated cell metabolism in sleep deprivation www.science.org/doi/10.1126/...

48 hours of empiric antibiotics in the first week of life blunts vaccine responses up to 15 months later through loss of Bifidobacterium. Effect could be rescued with commonly used probiotic. @nature.com

Shocked to hear about the sudden passing of Prof. Gary Lopuschuk @ualberta.bsky.social His contributions to the field of cardiovascular research is unmatched. It was my great pleasure to collaborate with him while I was @dalhousieu.bsky.social Terrible loss! pediatrics.cmail20.com/t/d-e-sdltux...

Our paper on the effect of herpes zoster vaccination on dementia is now out in Nature! 🎉 Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun! www.nature.com/articles/s41...

A broad impact of human gut commensal bacteria on GPCR-targeted drug structures and activities through diverse #microbiota-mediated biotransformations @naturechemistry.bsky.social www.nature.com/articles/s41...

Researchers describe how they are using skills honed in the laboratory in their creative pursuits https://go.nature.com/4jkH8Ii

Predicting #Alzheimersdisease Here elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia @naturemedicine.bsky.social www.nature.com/articles/s41...

Enhancing the Cre-loxP system: Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo. elifesciences.org/reviewed-pre...

Linoleic acid has been implicated in promoting inflammation and cancer. In Science, researchers report a mechanism by which linoleic acid can activate the mTORC1 protein kinase, which coordinates growth and nutrient signals. Learn more: scim.ag/4bPvmD5 #SciencePerspective

March 21st is #DownSyndrome Awareness Day and in Sweden & elsewhere it is observed as Rocka Sockorna or 'Rock your socks', where one wears mismatched socks. This is because the karyotype of the Down Syndrome chromosome look like mismatched socks. I'm rocking my socks today, are you? #RockYourSocks

Today we bid farewell our diligent & hardworking lab tech, Kaltum, as she goes on her maternity leave. We will miss having her around but we are very excited for her as she embarks on her journey of motherhood. We are looking forward to welcome the tiniest member of our group, soon 🙂

Dawn of a new era of #cancerbiology. Not all cancers are driven by DNA mutations with accumulating evidence of proteins underlying deadly cancers that are not DNA-driven. Comprehensive essay in @plosbiology.org on The end of the #genetic paradigm of cancer.

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Are you a microbiologist looking to move to Alaska? There is an opening for a microbiologist in a clinical lab in Bethel. Only requires a BS. Please share with your networks, they really need to hire someone ASAP. phh.tbe.taleo.net/phh01/ats/ca... #AlaskaSky #Microjobs 🧪🦠🔬

We are lucky to have incredible #diversity in our group where we learn about new cultures, languages & traditions. And what better way to learn something new than through food! Had a potluck with traditional cuisines across the globe today & evidently these scientists excel in the kitchen too!

The Sakamoto group members in action on Metabolism Day #MD25 , a 1 day international conference about energy control and metabolism organized by @cbmr.science , now in its 7th successful year!

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK

Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day! Happy International Women's Day! #WomensDay2025 #LatePost

Huge study in @nature.com by the @roychoudhurilab.bsky.social group #Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!

𝐋𝐄𝐀𝐏2: 𝐀 𝐧𝐞𝐰 𝐡𝐨𝐫𝐦𝐨𝐧𝐞 𝐰𝐢𝐭𝐡 𝐛𝐢𝐠 𝐢𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦? Research published today in @cp-cellrepmed.bsky.social shows that #insulin and #glucagon play a crucial role in regulating levels of LEAP2 - a newly discovered hormone with promise for treating cardiometabolic disease. 1/

SPEAKER LINEUP FOR STAND UP FOR SCIENCE ☀️ Here's our list of current speakers—and it's still growing! Come tomorrow to hear some amazing speakers talk about science, their experiences, and the future. #standupforscience2025

Pleased to share our new preprint describing mechanistic insights and cellular selectivity of the AMPK inhibitor.

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.