A big congratulations and thank you for all the marvelous achievements & hardwork to all members of the group. Looking forward for a productive and eventful 2026! Merry Christmas and Happy New Year to everyone from the Sakamoto group @cbmr.science

#Throwback 🧪 REVIEW | Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution @anneloftsdu.bsky.social‬ , M Emont, E Rosen et al.

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake. www.biorxiv.org/content/10.1...

#Throwback 🧪 COMMENT | From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research C Hsu & R Loomba

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3 www.science.org/doi/full/10....

Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀 & this year was @keisakamoto.bsky.social personal best 🙌🍾

RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1

Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science www.europeandiabetesfoundation.org/recipients/e...

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia share.google/dUNL7g7DkUle...

New PTM (lactylation) linked with #TFEB stability and increased autophagy and lysosomal activity @jcb.org

The protein kinase, GCN2 identified as the key amino acid sensor for mTORC1. @embopress.org @embojournal.org

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science www.nature.com/articles/s41...

Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise www.ahajournals.org/doi/10.1161/...

Among the ways for next generation GLP-1 medicines to differentiate: Efficacy, safety and outcome trials in type 1 #Diabetes www.cell.com/trends/endoc...

Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 receptor agonism and support durable #weightloss diabetesjournals.org/diabetes/art...

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise onlinelibrary.wiley.com/doi/10.1111/...

Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical development for obesity in 2026. www.biospace.com/drug-develop...

Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for guiding our junior colleagues. We wish her the best for her bright future! .

Happy to have contributed to this very interesting work ked/driven by Raid Nisr, Alison McNeilly and Graham Rena (University of Dundee). doi.org/10.1111/apha...

🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱 Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective? Prof. Jens Juul Holst outlines the evidence in Diabetes 👇 diabetesjournals.org/diabetes/art... #GIP #GLP1 #biotech #obesity

Great reads if you're interested in learning more about Salt-Inducible Kinases #SIKs in metabolism. pubmed.ncbi.nlm.nih.gov/40529046/ The Use of SIK Inhibitors as an Emerging Treatment... pubmed.ncbi.nlm.nih.gov/40384110/ Salt-inducible Kinase Regulation of Adipose Tissue Metabolism

miR-30a is a critical regulator of adipose tissue fibrosis that predicts metabolically healthy #obesity in people and mice @jclinical-invest.bsky.social www.jci.org/articles/vie...

Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19 https://go.nature.com/4jyBzpe

Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.

Nature research paper: Unravelling cysteine-deficiency-associated rapid weight loss https://go.nature.com/4mpetns

Habitual exercise, optimal glucose management and a healthy BMI maintain mitochondrial health in individuals with type 1 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...

A giant virus in the genome of Chlamydomonas - this week in @science.org #plantscience Cryptic infection of a giant virus in a unicellular green alga | Science www.science.org/doi/10.1126/...

Revolutionary!!

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. https://go.nature.com/437FWT6

New from the Steinberg lab #GDF15 drives anxiety like behaviors in mice and is linked to adipose tissue lipolysis.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes onlinelibrary.wiley.com/doi/10.1111/...

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.

A trial has drawn links between fibromyalgia and alterations of the gut microbiome https://go.nature.com/3EDZxkv

Increase in early onset colorectal cancer may be linked to childhood exposure to some types of E.Coli bacteria that produce genotoxin colibactin. @nature.com

Comprehensive review on the regulation of glucose and fructose metabolism from the @svenssonlab.bsky.social @annualreviews.bsky.social

Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein https://go.nature.com/3Gn657r

Sakamoto Lab (Metabolic Signaling Laboratory, University of Copenhagen) moves to Bluesky (1.775 followers in X) Bluesky: @labsakamoto.bsky.social #BlueSkyWins

Based on phenotypes in knockout mice with enhanced energy expenditure, the authors propose that drugs that inhibit MOB1 or activate YAP1 and/or FGF21 in adipocytes may be good therapeutic agents for diet-induced #obesity and/or type2 #diabetes www.pnas.org/doi/10.1073/...

A mechanistic update on gestational #diabetes diabetesjournals.org/diabetes/art...

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy physoc.onlinelibrary.wiley.com/doi/10.1113/...

If you want to understand how cells function, you have to work out what proteins interact with — and where https://go.nature.com/4hYLaol

In #ScienceAdvances, a special issue on #WomensHealth highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Learn more on #WorldHealthDay: scim.ag/3R59fPe

48 hours of empiric antibiotics in the first week of life blunts vaccine responses up to 15 months later through loss of Bifidobacterium. Effect could be rescued with commonly used probiotic. @nature.com