15 million Americans are going to lose their health care.

This is why I think Democrats need to let the GOP pass their budget. Let the voters see and feel what GOP government means. See if Ron is right about this not being a “gut-wrenching problem.” People need to understand what GOP rule is: Pain and poverty.

My husband was detained by ICE today Juan Muñoz, an American citizen, father of 2, and local government official, was peacefully protesting w. other elected officials. He was assaulted and taken away I have had zero contact or updates since #SOS @duckworth.senate.gov @durbin.senate.gov

I work with Veterans. If I told them that they "killed people and broke things for a living" they would (rightfully) tell me to go to hell. Those that have had to kill someone in the line of duty most often view it with sadness, regret, and one of the worst experiences of their lives.

Portland is not "war ravaged." This is delusional and dangerous. Sending troops into American cities doesn't make our communities safer — it just stokes fear and stirs up chaos. Trump is plunging further into authoritarianism every single day.

There is no world in which it is normal for the president to publicly call upon his attorney general to hurry up and prosecute his political foes. It’s like the Watergate tapes but posted on social media. Let’s get a grip on what’s happening here.

My guess is at least 500 #doctors at my #hospital are on H1B visas including at least a few dozen #hospitalists, and if we lose even a handful to other countries our house of cards #healthcare system will fall apart, let alone all 500+

I recommend everyone watches this

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

Congrats #DavidOReilly on the PLAN trial: plasma-first liquid biopsy (LB) v tissue (TB) for NSCLC in🇮🇪 @EJCancer - 138pts - 3wk⬇️ time to genomic result,LB>TB - 90% concordance - LB half the cost (micro-cost analysis) @oncoalert.bsky.social @cancertrialsie.bsky.social www.ejcancer.com/article/S095...

Beamion LUNG-1 trial: Safe, effective, oral therapies are needed for patients with HER2-mutant non–small-cell lung cancer. Research findings on the oral, irreversible, HER2-selective tyrosine kinase inhibitor zongertinib are summarized in a new Quick Take video. nej.md/3HETKwj #MedSky

Tonight, I'll go home and sleep in my bed. I have a lawyer, I'll get due process. But Edgardo, whose arm was ripped from mine by ICE agents, has none of those things. That's why I'll keep coming back to court, week after week, to make sure that people's rights are protected.

America has intersecting problems: -right wing hate -guns -media fragmentation -ignorance

A colleague, a friend and a brilliant scientist. The US lost a trusted vaccine expert to an anti-science purge at #ACIP Americans should be outraged.

@benlevylungdoc.bsky.social from Johns Hopkins reports results of chemo+datoDXD with biomarker data #ASCO25

Published in JCO today ascopubs.org/doi/10.1200/...

Herbert Loong presenting data on Sevabertinib in ERBB2/HER2 mutated NSCLC #ASCO25 Cohort with no prior treatment and another with no prior HER2 targeted therapy.

Data on iza-bren (BL-B01D1) an EGFR/HER3 ADC in patients with Small Cell and NSCLC (a variety of driver alterations). Fair response rate in all types of lung cancer (conf RR 48% in small cell) #ASCO25

Useful paper by my @mskdeptofmed.bsky.social colleagues looking at outcomes after radiation for "oligoprogressive" disease (<5 sites of progression) in patients with EGFRmut NSCLC. Show patients able to stay on osimertinib for median of 10 months longer ascopubs.org/doi/10.1200/...

The rank corruption of this administration is absolutely gobsmacking. Accepting a $400 million private jet from Qatar? What are the national security concerns? What is Qatar getting in return? Trump is a crook, and this is the most corrupt administration in American history.

Not such a big problem in clinical trials, but major challenge in retrospective research as well as lab-based research. www.nature.com/articles/d41...

Rubio publicly criticizing an ally for cracking down on right-wing extremism. And Germany hitting back. We are in a new world

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

Can we improve immunotherapy responses by depleting regulatory T-cells? Encouraging data in GBM www.cell.com/immunity/ful... Found with researchbriefing.com

#AACR25 April 29, 2025, 4:20 PM - 4:30 PM Room S406 (Vista Ballroom) McCormick Place South (Level 4) Thank you to the @theaacr.bsky.social and to @thelancetoncol.bsky.social for providing our team the forums for sharing the results from this trial. www.abstractsonline.com/pp8/#!/20273...

Peripheral blood film

“But to be human is not to have answers. It is to have questions—and to live with them.” Will the Humanities Survive Artificial Intelligence? www.newyorker.com/culture/the-...

Looking to be an outstanding @theaacr.bsky.social Clinical Trials Plenary session on Bispecifics and T cell engagers on Tues 4/29 10:15am CST featuring #wolchokj #hoperugo #jasonlukemd and other outstanding faculty. I am excited to be discussing CART in thyroid cancer in this great program

Important paper! We need better methods for helping patients and their doctors know when a clinical trial option is right and available.

Detaining someone for overstaying after a visa revocation you didn't inform them of in the first place.....

"With Sadness and Resolve: Why I Resigned as Chief Medical Officer of an #NIH Institute and What Comes Next" www.atsjournals.org/doi/10.1513/... [open access @annalsats.bsky.social ] Powerful essay, including resignation letter by Dr Josh Fessel in the tradition of www.linkedin.com/posts/nathan...

Imagine seeing this image four years ago. You would've wondered what tragedy befell our country where a scene like this could possibly happen.

Trump inherited a historically strong economy and he is single-handedly destroying it—and Republicans are letting him. We have got to speak out.

aside: a stunning comment from David Baker, UW professor who won the Nobel Prize in 2024. Now 15 lab members are looking for positions overseas. “There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”

This is really unfair to everyone who just voted for him for the racism.

LAURA OS update (LBA4) 👉 Now 31% maturity ❇️ 78% in PBO grp got Osi at PD ❇️ Improved PFS2 ❇️ Trend ⬆️ OS HR 0.67, not significant 💭 Confirm activity of Osi 💭 Crossover impacts OS difference 💭 Final maturity due @ 60% 💭 Surprised 1/3 Osi pts = no further treatment at PD #ELCC25

The MARIPOSA effect 🦋 ‼️Awaited OS data for #Amivantamab + lazertinib vs osimertinib in 1L EGFRm advanced #lungcancer presented at #ELCC25 🎯OS HR 0.75 (95%CI: 0.61-0.92) 🎉> 1 yr mOS advantage 🚫no crossover allowed, ⬆️intracranial activity ⬇️toxicity over time w prophylactic mgmt (skin) #lcsm

Results showing clear efficacy for chemo+IO in thymic carcinoma. We've known ICI efficacy for chemo followed by single-agent. Now do we do first line chemo+ramucirumab followed by IO or first line chemo+IO? We need a randomized trial in thymic carcinoma! www.thelancet.com/journals/lan...

Maniatis: "NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes America’s global leadership in science and medicine." www.cell.com/cell/fulltex...

SignalGate Is Bad; But OPSEC Isn’t Even the Worst Part Of It talkingpointsmemo.com/edblog/signa...

Honoured to co-first author this important paper with Prof Herbst and the entire team looking at MRD in the ADAURA trial. www.nature.com/articles/s41...

Plasma MRD kinetics in the 18 of 220 ADAURA patients who had baseline MRD+ after surgery +/- chemotherapy. Any reason why the baseline prevalence of MRD+ is higher in the placebo group? Groups were well matched for chemo receipt, nodal staging, surgery type. Just small n? #OncSky

But beware of the real world…. Potentially less fit patients as compared to the trial population #BTOG25

Updated @ascocancer.bsky.social living guidelines for NSCLC are out! Participating on the Expert Panel not only gives me hope to see so many new treatments, it also reminds me how challenging it must be for clinicians to keep up. ascopubs.org/doi/10.1200/... ascopubs.org/doi/10.1200/...

Rubio terminated 5800 USAID contracts – more than 90% of its foreign aid programs – in defiance of the courts. Here’s a list of just some of the lifesaving awards that were terminated. Nearly all were Congressionally mandated. They’ve saved millions of lives. 🧵

WHO comments on United States announcement of intent to withdraw bit.ly/4hrbeJ7

New book out, by William Pao. Great stories about developing drugs. Definitely covers EGFR, but other important medicines as well. It is a great read.