Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

What a pleasure and honor to have the Nobel Prize @jimallisonphd.bsky.social and the brilliant @pamsharmamdphd.bsky.social at Regina Elena National Cancer Institute in Rome, for the Raffaele Tecce memorial lecture. Immuno past and future! #savelife

Submit your abstract by Dec. 19 (11:59pm MST) to secure a poster presentation spot at our Precision Oncology meeting. Connect with experts such as @pamsharmamdphd.bsky.social in precision medicine, cancer treatment, and health equity! hubs.ly/Q02_9vH10 #KSPrecisionOnc25 @mdanderson.bsky.social

Spatial Proteomics named ‘Method of the year’ by @naturemethods.bsky.social . Very exciting technology 🔬 #science #research #omics www.nature.com/articles/s41...

Jim Allison, amazing leader and inspiration!

Let’s see… David Baker and Victor Ambros! And Jim 🤓🧐

De novo protein synthesis for specific recognition of peptide-MHC complex! This represents the potential for significant advancement in the development of immunotherapies! doi: doi.org/10.1101/2024...

How many Nobel Laureates can you name? It was an absolute pleasure to spend time with friends, including Sid Mukherjee & Doug Hanahan & Sabeena Merchant, and to hear stories of science, dedication & teamwork that led to the Nobel Prize for these brilliant, compassionate, fun & badass individuals!

Nobel Prize Lecture in Chemistry with incredible promise for the future to use AlphaFold & development of new proteins to improve treatments for diseases and provide sustainability for our planet! Congratulations to David Baker, John Jumper & Demis Hassabis @demishassabis.bsky.social

Working on my end-of-year analysis for public health and came across this shocking statistic: The percent of Ameircans vaccinated for the flu has dropped from 67% in 2019 (pre-COVID) to 38% today. Influenza has been a leading cause of death in America almost every year since at least 1980.

#SEVERANCE 1 17 25 youtu.be/_UXKlYvLGJY

Nobel prize week, a yearly celebration of science. Great to catch up with @jimallisonphd.bsky.social & @pamsharmamdphd.bsky.social back again in Stockholm.

Brilliant lectures today by Victor Ambros & Gary Ruvkun for 2024 Nobel Prize in Medicine! I learned a lot about the Worm Breeders Gazette 🪱

🚨2024 VinFuture Special Prize for Innovators with Outstanding Achievements has been awarded to Professors Zelig Eshhar (Israel), Carl H. June, and Michel Sadelain (United States) @PennMedicine @vinfutureprize www.accesswire.com/951373/the-2...

Back in Stockholm to celebrate Nobel Week with @jimallisonphd.bsky.social Always so much fun!! 🤩❤️🥰💕

#Science 🔭 is awesome First Ever Image of a Multi-Planet System around a Sun-like Star Captured by ESO Telescope www.eso.org/public/news/...

Intro time! I'm Hind, a mucosal #immunologist working in KU Leuven on mast cells in health and in gut disease. Speaking of, I can finally show what I have been working on for the last 4 years, ie characterizing human mast cells in layers of the colon via scRNAseq www.biorxiv.org/content/10.1...

Noor (@noorpratap.bsky.social) has been working on this for quite some time! It took a bit of work to figure out, but now you can map your scATAC-seq reads directly to the genome and sort and dedup them with alevin-fry-atac. You get a BED file with counts ready for downstream analysis! 1/

Our new tradition every Thanksgiving. watching Jim Allison: Breakthrough movie. Must-watch, especially students interested in science and medicine. Modern day #superman (cape missing) who saves millions of lives. Inspirational @jimallisonphd.bsky.social @pamsharmamdphd.bsky.social amzn.to/4gdxXaR

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods --> www.biorxiv.org/content/10.1...

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer www.nejm.org/doi/full/10....

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Briefly re-reading this paper in preparation for giving my talk this morning at EMDS2024. Such a lovely paper. www.nature.com/articles/s41...

A new method to recover biological signal lost after data integration. GitHub: github.com/Janezjz/cell... Nature Biotech Paper: www.nature.com/articles/s41...

HPV vaccine stops 90% of cervical cancer cases in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 www.bbc.com/news/article...

Welcomed Dr. Charles Blanke to Rhode Island Hospital/Brown University for grand rounds. What a career he has made- GI oncologist ➡️ SWOG Group Chair ➕️ tireless advocate for compassionate care - and autonomy- at the end of life. Proud to call him friend. #oncsky h/t @weldeiry.bsky.social

www.nature.com/articles/s41... My friend @chrischirp.bsky.social pointed out I can't just lazily paste links to a paper of interest without any explanation! We all buy into gut microbiota shaping immune populations and programmes, but this study adds huge granularity, by anatomical region and subset

in lively festivals each spring throughout Catalonia (Spain), microbiology professors and their postdocs thrill crowds by reenacting the assembly of a type 3 secretion system (T3SS)

Join me for this webinar on "Induction, persistence and function of microbiota-specific CD4 T cell memory" organised by the fabulous DGFI young immunologist group! 🗓️ 12 Dec 2024 🕔 17:00 CET Registration: t.co/oc24P9uZYH Thanks for sharing!

Only a subset of patients respond to immunotherapy Why? Which ones? We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response. www.nature.com/articles/s41...

Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy! www.nature.com/articles/s41...

Day two of sharing one message of gratitude until #Thanksgiving. Today, I’m sharing a note of thanks to my wife, Katie, and my two daughters, who continue to be my unwavering source of support, love and inspiration. 💙

Grateful as we approach Thanksgiving for the inspiration of people I admire - Kristen Hege for a 2,600 mile hike to fundraise Supporting the Early Research Careers of Women @pennmedicine.bsky.social socialfundraising.apps.upenn.edu/socialFundra...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...

Nice review! I’m sure we will have combination strategies in the clinic on the next few years but must balance efficacy with cost/side effect profiles

Combination approaches for checkpoint inhibitors - #immunotherapy #cancer #oncsky Very good review article by @pamsharmamdphd.bsky.social

Awesome review on combination strategies with ICB #CancerImmunotherapy #ImmuneCheckpoint

Great time tonight with guest Dolores Hambardzumyan and our colleagues Jason Schenkel, @wenjiang-nano.bsky.social and #JPAI members @pamsharmamdphd.bsky.social @jimallisonphd.bsky.social Xi Chen @mdanderson.bsky.social #myeloid #GBM #endcancer

REVIEW: Next-generation combination approaches for immune checkpoint therapy www.nature.com/articles/s41... @pamsharmamdphd.bsky.social

Check this recent review about next-generation combination approaches for immune checkpoint therapy! 💊 @natureportfolio.bsky.social @pamsharmamdphd.bsky.social www.nature.com/articles/s41...

📑 What a comprehensive review! 👏 ICIs have come so far - so many combinatorial strategies. Rational/precision tx & biomarkers remain areas of unmet need. Will AI/ML 🤖 help? So much more to do. Hopefully our #MANIFEST project (manifest-io.org.uk) can also contribute to this in the coming years.

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

www.nature.com/articles/s41... Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang

Welcome @jimallisonphd.bsky.social 💕😘❤️💕

Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA

Linked paper: Effectiveness and safety of immune checkpoint inhibitors in Black patients versus White patients in a US national health system: a retrospective cohort study ➡️ similar ICI effectiveness ➡️ lower rates of irAE www.thelancet.com/journals/lan...

Way too cute

#MusicMonday Moffitt Cancer Center's band, #TheReMissions, recently performed at The Leukemia & Lymphoma Society's Tampa #LightTheNight event, celebrating and remembering those touched by blood cancers. Here's our cover of "The Climb" by Miley Cyrus, a song with powerful themes of resilience & hope!

Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park go.bsky.app/Gi2dcGd Drop me a beep to get added or suggest others!