For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

We have 2 vaccines that prevent cancer, the HBV vaccine that prevents hepatitis B related liver cancer and the HPV vaccine that prevents cervical cancer and other HPV associated cancers. On Thursday, RFK.JR's ACIP will attack one of these vaccines (HBV) and restrict access to it. Let that sink in!

you don’t understand bro, if we didn’t lie, no one would buy our product 😩

Thinking about running a TCR generation contest: We give you a set of pMHCs without known cognate TCRs You give us your top k in silico TCR designs We test them for cytotoxicity as TCR-Ts against cancer cells that are validated to express the target Who’s in?

The drosophila Dscam1 gene presumably evolved specifically to mess with bioinformaticians

And learn what fully AI-generated websites look like. Avoid them, as they are more likely to be scam.

Bioinformaticians / computational biologists take note - know where you should take your OS tool chain from and do not introduce backdoors.

This is a cool story that I've watched with great interest - making big steps in the field of de novo TCR generation! Great work @dkarthikey1.bsky.social / @benjamingvincent.bsky.social / @alexr.bsky.social et al

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

It doesn’t matter if you feed your kids organic foods, MAHA moms. It doesn’t matter if you lift every day, bro. It doesn’t matter how many supplements you consume. When polio, diphtheria, measles, mumps, and whooping cough come a calling, all that matters is if you are vaccinated or not.

A nice reminder that even the most fundamental 'rules' of biology are basically just strong suggestions

Nothing like a lab space renovation to reveal the untold horrors that lurk underneath the equipment

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im... This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…

How to represent genomes in 3D? In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅 👉🏼 genomebiology.biomedcentral.com/articles/10....

Notable paper TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors #tumor #immunology buff.ly/L23yhOe

This is such incredibly good value for some of the best modern SFF that I'm tempted to buy them all again just because

this iconic advertising copywriter named Kathy Hepinstall Parks died over the weekend and I wanted to share something from her website I thought Bluesky would like

My generation had to deal with datasets where Excel had autocorrected gene names to dates. Future generations are going to have to deal with the hallucinations of slopbots.

A+ society stepping up

Boss. I'm tired boss. We been doing these experiments and studies since the 60s and 70s and the outcome has been the same in them all. The pushback against these measures aren't because they don't work. It's because they DO work and they'll include peoples they wish to exclude from society.

Got new #TCR-pMHC data to send our way into BATCAVE? Wanna try BATMAN to predict targets of your #TCR? We would love to hear from you! 💽Database+codes: github.com/meyer-lab-cs... 💻BATMAN software + tutorials: github.com/meyer-lab-cs... 🦇Lets decode TCR-pMHC logic, one mutation at a time🦇

Not thrilled by the LabArchives parent company being acquired by Siemens (seemingly to snaffle up their either lifesci softwares). Being an afterthought in big business shuffles doesn't seem like the ideal positioning for an ELN service.

🚨 Publication Alert! AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences: 👉 alignair.ai Explore the paper for results and methodological details: 📄 lnkd.in/dKY5fPZz It’s been a long, creative, and rewarding journey with an amazing team. We’d love to hear your feedback!

New study popped up in my feeds this week which looks to have a lot of useful things to say about predicting TCR:pMHC interactions: dx.doi.org/10.1002/eji.202451607 Also, having seen (and made) a lot of tortured TCR-related named, 'nuTCRacker' is top tier.

How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵

Heard the one about how UK services exports were booming after Brexit?? Another myth, sadly... My column www.ft.com/content/3e9d...

Heads up TCR and immunoglobulin researchers: a nice piece keeping you updated on the efforts undertaken to make sure the TR/IG nomenclatures we use make sense

I'm gonna start bringing opera binoculars to conferences, only way I'm going to be able to make anything out on these tiny multi-plot slides

Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪

Are you at #FOCIS2025 and interested in TCR and IG research? A bunch of AIRR-C people are running a session this afternoon from 1:30 in Salon H cdmcd.co/ZK89MB (where I'll be giving a little intro the shiny new AIRR-C TCR germline reference set that we're making!)

Mahmoud Khalil is finally home with his beautiful wife and newborn son. Each one of the 104 days he spent detained was a grave injustice. From the moment of his detention, @ccrjustice.org + @aclu.org engaged my office as we worked closely to help secure his release. They did remarkable work here.

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

I am once again pitching my romantic comedy: - two academics start dating - discover they are each other's terrible reviewer - hijinks ensue Working title: Love is Double-Blind

I'm sorry. I stopped typing and just listened. I'll post summaries as they're published. But the end was that Judge Young went on to defend judicial independence and to underscore the perilous moment in American history where racial discrimination is tolerated. He ends with "Have we no shame?"

I’ve warned that this was only a matter of time, but it’s still shocking to see in person. Here AI generated content is being used to create a fake news ecosystem, disparaging a professor who has been critical of unscientific bullshit in the form of deextinction hype.

If randomly kidnapping people (including first grade kids) from places of work, education, worship, and immigration appointments and disappearing them without due process to foreign prisons does not meet your definition of fascism, then your definition of fascism is wrong.

RFK Jr.‘s extreme anti-vax views — and his related conflicts of interest — were a huge problem during his confirmation process. So he promised not to change the vaccine advisory panel. Today, he fired every single expert on that panel. It's a public health disaster.

Holy smokes! Our article is on the cover of The Lancet!!!!!!!!!! Nbd 💅

Today more than ever I think it is important to remind ourselves that #ElonMusk led indiscriminate cuts which have resulted in the estimated deaths of over 300,000 people globally to date. 2/3rds of these are children!!! He is still very much a villain. www.impactcounter.com/dashboard?vi...

Lyft driver picked me up from UNC, turned out he was a medicinal chemistry post-doc in a building near mine, until his grant got cut last month. Worked on novel antivirals.

I personally know 5 early career and trainee level academic scientists who have changed jobs/ career paths in the last month. They did not see a sustainable future with ongoing cuts and attacks. The scale of decimation of the pipeline that the scientific workforce in U.S. faces is staggering.

Ew yuck, I have to use Teams now

This policy is going to kill pregnant women and their babies. Please, if you are pregnant or know someone who is, urge them to get vaccinated for COVID-19.

Very much sums up my thoughts. Absolutely shameful behaviour from Starmer.

Here is the Bonsai visualization of a realistic dataset. In contrast to UMAP or PCA, the Bonsai tree accurately reflects the structure in the data. Not only visually, but the correlations between the true distances and distances in the Bonsai representation are close to 1 for almost all cells.

Rümeysa Öztürk should never have been abducted and unlawfully detained. She is a cherished member of our community and I'm so relieved she is headed home to the #MA7. This is a victory for Rümeysa, for due process, and for our democracy.

So many of us will lose our labs and lose our jobs.