If you thought human IG was complicated, ruminant IG wants to change your mind! Awesome overview of the ruminant IG genomic landscape by Yana Safonova (Penn State) www.annualreviews.org/content/jour...

🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social academic.oup.com/nar/advance-...

Query by ancestry, tissue, chain, or study. Explore allele usage, haplotypes, and gene presence/absence with interactive tools. Download via API or browser. Fully FAIR, MiAIRR-compliant, open, and versioned. vdjbase.org #AIRR #Immunogenetics

New manuscript out in NAR! tinyurl.com/4rrbuesn 🧬 VDJbase and OGRDB now support 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. From population analysis to precision annotation. @guryaari.bsky.social @cdubsig.bsky.social @williamlees.bsky.social

LifeSciKY has welcomed three biotech startups to the new OneNKY Center in Covington. Learn more about the companies and their work in cancer research, immune profiling, and fertility innovation. linknky.com/business/ent...

Excited to see our work on IGHC diversity out! Huge shoutout to @uddalok.bsky.social for leading this study. 🧬 The data is now available on VDJbase, our open resource for exploring B and T cell germline variation across populations. 🧑‍🔬 Go and Explore vdjbase.org! #immunogenetics #VDJbase

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors. @williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social www.cell.com/cell-genomic...

'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'

I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im... This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…

FFS.

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles: www.sciencedirect.com/science/arti... @jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

Check out this week's newsletter, featuring @clareobio.bsky.social!

Thrilled to be featured in GenomeWeb! 🧬 Stuck behind the paywall? We got you. Here's the TL;DR on how Clareo is pioneering the next generation of immune profiling with full-length antibody sequencing. Find it here: lnk.bio/clareobio #Biotech #Genomics #LongReads #Immunology

🌟 Meet "Rosie" - our new @pacbio.bsky.social Vega sequencer! Named after Rosalind Franklin, she'll supercharge our ProfilAIR & GenotypAIR services with faster, more comprehensive B & T cell receptor profiling. Better data = better biomarkers, faster vaccine design, and more precise therapeutics!

Big win for science: The US senate rejects 40% cuts to NIH funding and instead proposes $400M increase. A clear sign that Congresd is standing behind biomedical research www.nature.com/articles/d41...

Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics. 🔗 doi.org/10.1093/molbev/msaf152 #evobio #molbio

Know an Evolutionary Genomicist looking for a faculty position? Join us in EEB @utknoxville.bsky.social Position is open for studying any organism, but personally I have some botany bias. 🌱 Apply before Sept 19 for full consideration. apply.interfolio.com/170735 Please share widely. Thanks!

Are you an immunologist working towards your first R01? Please join @aai.org and take advantage of programs like our Grant Review for Immunologists Program www.aai.org/Careers/GRIP We pair early career principal investigators with established mentors. Send me a chat for more info

5/6 What can we do now? We outline strategies in the paper: ✔️ Clear, provisional reporting formats ✔️ Transparent criteria for future naming ✔️ Global dialogue to shape consensus Let’s build something better—together. 🧠🌍 iuis.org/committees/n...

6/6 📄 Read the full commentary: “Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era” 👉 www.sciencedirect.com/science/arti... ✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social

1/6 🧬 NEW COMMENTARY 🧬 Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics. A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics. #IGTR #Genomics #Immunology

An overview of the future of IG and TR gene nomenclature www.immunoinformaticsjournal.com/article/S266... @yanasafonova.bsky.social @elisarosix.bsky.social

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

@guryaari.bsky.social giving awesome overview of ML approaches for AIRR-seq data - FOCiS 2025 @airr-community.bsky.social

@ayeletperes.bsky.social providing excellent overview of AIRR-seq tools at FOCiS 2025 @airr-community.bsky.social

@williamlees.bsky.social highlighting useful AIRR-C resources at FOCiS 2025 in Boston @airr-community.bsky.social @focisimmunology.bsky.social

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors! Way to go Eric @e-engelbrecht1.bsky.social !!!! www.biorxiv.org/content/10.1...

New preprint from our group in collaboration with the awesome Prof. Ranjan Sen (NIH). We show that IGH polymorphisms establish inter-individual differences in the pro-B antibody repertoire that persist into the naive B cell pool. Oscar L. Rodriguez is killing it! www.biorxiv.org/content/10.1...

Our primate T2T paper came out in Nature yesterday! It was a huge effort and I'm so grateful that I got the opportunity to work with this amazing group of scientists over the first two years of my PhD! www.nature.com/articles/s41...

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social www.biorxiv.org/content/10.1...

Hello world! Have you heard of the AIRR Knowledge Commons yet? The AKC is being established as an integrated resource immune receptors, repertoires, antigen specificity and germline gene information. Want to know more? We have recently updated our website: airr-knowledge.org

Planning to go to #AAI this year? Come visit our shared super booth!

Amazing work by @yanasafonova.bsky.social et al. on immunoglobulin and T cell receptor loci across mammals. www.biorxiv.org/content/10.1...

Excellent summary of the importance and the impacts of NIH-supported research. Helpful for those wishing to discuss this or write about for non-scientists. Part of a collection on Science Under Threat in the US. See elifesciences.org for more. 🧪 elifesciences.org/articles/106...

Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@[email protected] for ++ hard work!🌟

A truly enjoyable and collaborative effort—this is what science should be all about!

Very proud of this collective effort to enhance understanding of immunoglobulin diversity in rhesus macaque @guryaari.bsky.social @williamlees.bsky.social www.biorxiv.org/content/10.1... --> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...

The IMMREP25 TCR specificity prediction challenge is now live on Kaggle! Get involved: kaggle.com/competitions... Huge thanks to: Matthew Noakes, @the-dee-em.bsky.social, @everichardson.bsky.social, @bjoernpeters.bsky.social , @adaptivebiotech.bsky.social , IEDB, @airr-community.bsky.social

Melissa Smith just delivered an incredible talk on how #HiFisequencing is transforming immune response research and vaccine innovation. Have more questions? Stop by our hospitality suite (Lanai #289) tomorrow at 10 AM for an AMA with Melissa! #AGBT #PacBio #AGBT25

Melissa Smith is highlighting how the Smith & Watson labs are uncovering the genomics behind personalized immune responses and viral persistence with Revio. Highly accurate #PacBio long reads are key to resolving complex immunogenomic structure. #AGBT25

Genotype matters. At #AGBT25, Melissa Smith explores how germline-targeted immunogens and IGH variation impact immune response. Highly accurate #PacBio long reads help reveal critical insights for immunogenomics and precision medicine. #AGBTGM

Current AIRR-seq methods have limitations. At #AGBT25, Melissa Smith showcases how #PacBio highly accurate long reads provide the resolution needed to fully understand immune responses—paving the way for better immunotherapy and precision genomic medicine. #AGBTGM

PacBio has kicked off our talk with Melissa Smith at #AGBT25! 🌟 Stay tuned as Melissa dives into how PacBio #HiFiSequencing is transforming immune response and vaccine research. Don’t miss the insights ahead! #PacBio #AGBT

tap... tap... this thing on? Excited to be at #AGBTGM introducing @clareobio.bsky.social foundational data and services, sponsored by @pacbio.bsky.social. Clearly they saved the best talk for last! Come by and learn all about our comprehensive solutions to adaptive immune profiling.

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social www.biorxiv.org/content/10.1...

8/10 In this context, @yanasafonova.bsky.social explains the importance of assessing the quality of genome assemblies and encourage scientists to perform these pre-flight checks before using assemblies as references for new gene annotation

7/10 Different data types on the rise over the past years have the power to unravel new knowledge but also call for specific quality assessments.