Listened to a Global ImmunoTalks seminar by Marc Jenkins on rare antigen-specific T cells in the naïve repertoire, including Tregs. Now it’s published in JI. Submission date June 30, one day later and it would’ve been free to read. Now? Nope. #immunology buff.ly/qqigH1P

New evidence shows that long-lived IgE plasma cells exist and are found mainly in the spleen rather than the bone marrow. This could add another layer to our understanding of how IgE drives persistent allergy. #allergy #immunology buff.ly/CVRc5OE

Oncolytic viruses looked promising, but trials showed they could not eradicate metastasis. New experiments reveal why: they prime T cells against the virus, not the cancer. #cancer #immunotherapy #oncolytic buff.ly/faTnvij

#Bacteroides fragilis was hyped for 15 years as a Treg inducer and anti-inflammatory so much so that biotech companies were founded on it to capitalize on the early data . Now? Oops. #immunology #science #gut #inflammation

The Weekend Tunes FLM - Ráncok a szemem alatt (🇭🇺 Hungary) FLM has returned after 30 years with a genuine new synthpop track. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 www.youtube.com/watch?v=gydv...

IL-21 mimic "21h10 led to lethal pancreatitis in mice, this toxicity could be mitigated by TNF blockade" Yet it is still being described as a #breakthrough, which points to a serious lapse in both experimental judgment and peer review. #immunology buff.ly/NJwymQo

This form of complex decision-making in the termite nervous system approaches that of primate, or at least mammalian, brains. It illustrates how nature often reuses fundamental neural architectures rather than constructing them anew. #science buff.ly/21VgBVx

"Science winnows submissions using a team of full-time professional editors" [former scientists] This arrangement highlights a paradox of gatekeeping in #science, where editors with modest academic records decide the fate of more accomplished researchers. buff.ly/WGL76W8

My only regret is that we didn't go with the title "One buffer to rule them all, and in the darkness bind them", although "Squeaky clean staining" was a pretty good options too!

🟥On the 255th day of her unlawful detention, Mzia Amaglobeli was nominated for #SakharovPrize 🟥Nomination “Mzia Amaglobeli and Georgia’s Pro-Democracy Protest Movement,” was initiated by Rasa Juknevičienė, Tobias Cremer, Petras Austrevicius, Sergey Lagodinsky, and co-signed by 66 MEPs from 5 groups

Why T Cell Tolerance Is Fixed from Birth 1. Unlike the innate immune system, which uses receptors to discriminate self from nonself based on biochemical features of the ligand (like LPS, foreign DNA, or foreign RNA) #immunology #tolerance #selfnonself #science #theory #Tregs

They now rewrote it

Thought I’d seen great series, but 'The Leopard' sets an entirely new standard. A stunning portrayal of Sicily’s transformation during Italian unification. Absolutely splendid. Only Sweden’s 'Anno 1790' compares. #Netflix #Leopard #TVseries buff.ly/5MiDUK0

Not just ‘memory T cells act as microbial surrogates to drive innate immune activation and inflammation’, activated CD4 T cells can as well. This is precisely why only antigen-specific Tregs can keep anti-self T cell responses from spiraling out. #Foxp3 buff.ly/hmM40L0

The president announced Friday that H-1B visas will now come with a $100,000 annual fee, but a U.S. official said it will only apply to new visa applicants. #H1B #update buff.ly/87a6Sm9

There’s a clear contradiction between the article’s title, snippet, and content. The headline claims ‘millions in grant money begin trickling back to scientists,’ but the article itself says ‘payments have not been restored.’ #science #funding buff.ly/gl3dssA

Does the new $100K H-1B fee apply to universities and research institutions? If so, it could deliver a major shock to biomedical science. #H1B #science #academia buff.ly/OMYLqOX

The Weekend Tunes Anna Vissi (Άννα Βίσση) - Sandre (Σαντρέ) - Dirty Blond (🇬🇷 Greece) Second time I’m picking an #AnnaVissi song for best #popsong of the week of randomly listened songs. Absolute fire 🔥 #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 www.youtube.com/watch?v=6gP_...

Trump to impose $100K fee on H-1B visas in new immigration action buff.ly/VC0vRPi

Running massively parallel reporter assays on more than 18,000 autoimmune disease associated variants in T cells, only to land on T cell proliferation targets. Feels like hitting a fly with a drone. #science #immunology #BigData #Genomics buff.ly/k30pVij

op-ed: Academic Publishing Performs a Public Service The peer-review process is thriving, not broken. #academia #peer_review #NIH buff.ly/jEiAJMv

This looks like a major study on how adjuvants can help drive anti-tumor T cell responses. #tumor #immunology #immunotherapy buff.ly/TqMKJSU

Reading this @Nature piece, it really is just the old proverb: he who pays the piper calls the tune. When is asymmetrical power ever given up voluntarily? At the very least, it requires seeing others as extensions of self, not as foreign. #society buff.ly/X2wbqbg

The Atlantic: AI Executives Promise Cancer Cures. Here’s the Reality #AI #biology #science buff.ly/QMeKa7d

NYT: Trump Is Shutting Down the War On Cancer #science #NIH #cancer #immunotherapy #grants t.co/GQPWmp7Lvj

Yasmin Belkaid's lab reports that endogenous retroviral elements promote oral tolerance. Yet their germ-free mouse experiment conflicts with prior evidence that oral tolerance does not occur in such conditions. This needs clarification in the discussion. @belkaidlab.bsky.social buff.ly/cS4RK17

The Weekend Tunes Martynas Kavaliauskas - Ant Debesų (🇱🇹 Lithuania) #Lithuanian pop has a unique melodic quality. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 www.youtube.com/watch?v=RuHK...

Nice overview by Simon Fillatreau et al. on antigen-specific Treg development. But they miss the point: saying high funtional affinity thymocytes become Tregs and low-affinity become Tconv. Who gets deleted then? Weren’t those high-affinity clones? buff.ly/cGPglCS

LLMs are probabilistic systems, not creative engines. They don’t generate novelty, only recombine known information statistically. And the fact that scientists didn’t disclose a proven hypothesis doesn’t mean others hadn’t already proposed it openly. #AI #LLM www.cell.com/cell/fulltex...

Loss-of-function mutations in PLD4 as a monogenic driver of systemic lupus erythematosus #lupus @nature.com www.nature.com/articles/s41...

1/ This “working model” of Treg suppression (Shevach et al., 2006) has dominated immunology for 25+ years with little scrutiny. It proposes that Foxp3⁺ Tregs suppress T cells in an antigen-non-specific manner:a Treg specific for A can suppress T cells specific for B. #immunology

Honestly, I don’t get it. They call one group “tolerant” and the other “non-tolerant,” yet neither shows problems with the pathogen. Then they end the study at day 28, even though both are still infected. Either I’m missing something, or the study is. #immunology buff.ly/6iyPnUI

An ecological approach to treating immune disorders is highly relevant. Yet in humans, unlike in mice, helminths don’t work well. Perhaps their effect depends on microbiota species missing in MS patients. #immunology #multiplesclerosis #worms buff.ly/cBNGInn

The most annoying thing in immunology? People using math formulas to “explain” immune behavior. They should be permanently disqualified from the discussion. #immunology #science buff.ly/Qosm8nR

It’s puzzling that the authors don’t see the contradiction: repeating familiar experiments with little novelty, then asserting OVA feeding enhances Th2 yet suppresses it upon challenge. This should be clarified before publication. #immunology #science buff.ly/PZzDKXF

The Weekend Tunes IVE(아이브) 'XOXZ' (🇰🇷 South Korea) STUDIO CHOOM ORIGINAL IVE has the best songwriters in K-pop right now. #Kpop #WorldMusic 🌍 🎧 #MusicUnites ❤️ 🎵 youtu.be/Te78AQ4OY0w?...

At the heart of Afghan self-understanding is the belief they preserve Islam in its purest form even though few can read Arabic. This conviction gives Islam unique legitimacy as the foundation of law and political authority. #afghanistan #history buff.ly/Jt3M5mv

longer post limits should be standard across social media, including X, and accessible to everyone for free. buff.ly/GmQFpmE

Exceptional finding: octopus behavior is regulated through chemical sensing of microbial signals in the environment. #octopus #microbiome #holobiome buff.ly/2YlhoB9

News/Views: Studies deliver new blow to cancer microbiome literature—and offer a way forward #science #microbiome #cancer buff.ly/P3pGFWh

Notable paper. It shows stress-induced amygdala–liver signalling increases vulnerability to metabolic abnormalities such as weight gain and T2D-like blood glucose changes without altering food intake or glucoregulatory hormone levels. #science buff.ly/zMiaZVE

Judge Apologizes to Conservative Justices in Case Over N.I.H. Cuts #NIH buff.ly/Lqb4wIO

"An effectiveness of about 45% against hospitalization" is the opposite of 'not nothing'. it’s basically ‘nothing,’ because at the individual level anything below 50% is essentially 0%. You can’t know if you’re in the protected or unprotected group. buff.ly/dUyzxyO

I didn’t realize woke thinking was quietly overtaking immunology. From the abstract: “This active vaccine suppresses autoimmunity” … “In a mouse model of atherosclerosis.” So now atherosclerosis is being rebranded as autoimmunity. #immunology #science

I didn’t realize woke thinking was quietly overtaking immunology. From the abstract: “This active vaccine suppresses autoimmunity” … “In a mouse model of atherosclerosis.” So now atherosclerosis is being rebranded as autoimmunity. buff.ly/RKa5Rfz

On Sunday, the International Association of Genocide Scholars said that Israel’s nearly two-year military campaign in Gaza, which has killed tens of thousands of people and left swaths of the enclave in rubble, meets “the legal definition of genocide.”

In this brief essay, Paweł Kisielow reflects on his path into #immunology and his discovery of antigen-specific clonal deletion in the thymus using one of the earliest transgenic mouse models. Note to public: "transgenic" is not the same as "transgender". buff.ly/vX3b8zk

Why the FDA Doesn’t Support Covid Boosters Forever By Marty Makary, FDA buff.ly/ENgUBcy

'the start-up was all “smoke and mirrors.”' #AI buff.ly/tpm9Ipc

Notable study: It shows that during infection, T cell activation forces the heart to switch from glucose to fatty acids, a metabolic shift essential for survival. #immunology #infection #metabolism www.biorxiv.org/content/10.1...