🚨Congratulations to Prof. Dr. Carl June & Prof. Dr. Michel Sadelain! 2025 laureates of the Broermann Medical Innovation Award for the development of the CAR-T cell #immunotherapy #cancer #CancerResearch pressreleasehub.pa.media/article/dr-c...

Is Germline Editing Feasible and Should it be Permissible? I joined @urnov.bsky.social, @kiranmusunuru.bsky.social, ISCT President Miguel Forte & Chief Regulatory Officer Bambi Grilley to discuss #ethics #bioethics & technological hurdles of embryo editing www.isctglobal.org/telegrafthub...

My CNBC.com segment on implications for pediatric vaccine schedule from recent politics. 2003 saw ~5,000 cases of pertusis, in 2024 there were over 35,000, and for 2025, some models show 70,000+ We risk a return of communicable diseases in children. www.youtube.com/watch?v=00cI...

How future cures begin as ideas in laboratories ft. Carl June, @bllphd.bsky.social (@pennpathlabmed.bsky.social), David Porter, Stephen Bagley, Jakub Svoboda (@penncancer.bsky.social) & Donald O'Rourke (@PennNSG) tinyurl.com/32hd7y2m

🚨Just published - Multiplex engineering using microRNA-mediated gene silencing in CAR T cells #celltherapy #genetherapy #immunotherapy www.frontiersin.org/journals/imm...

Announcing the website for the song Ring That Bell 🔔 cowritten w @magsmccarthy.bsky.social an emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer new hope. #cancer #cancerresearch #immunotherapy #hope ringthatbellsong.com

Nearly two dozen people developed food poisoning in Florida after consuming tainted raw milk from the same farm, state health department says (from @reportergoodman.bsky.social) www.cnn.com/2025/08/05/h...

🚨Coming soon! Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. In a single lentiviral vector- multiplex silencing & expression of a CAR, better expansion & viability than gene editing by electroporation www.frontiersin.org/journals/imm...

More disease coming, unfortunately in kids. Adults making the bad decisions for them.

My new 2-minute 5-point short on why one shouldn't go to stem cell clinics or at least seriously weigh risks + low chance of benefit. Good little video for scientists and physicians too looking for clear explanation when people ask #stemcells #stemcell www.youtube.com/shorts/EX9iU...

Cutting NIH to “save” money is fundamentally flawed -Modest annual savings pale compared to multi‑trillion‑dollar health, innovation, and productivity losses www.statnews.com/2025/07/28/n...

From Pink Sheet on continued departures from FDA’s biologics division and challenges backfilling openings. FDA biologics center reported 106 departures from Jan. 1 to June 30. These numbers don’t include the 100-150 who were part of the reduction-in-force insights.citeline.com/pink-sheet/a...

FDA’s cancer review team overseeing breast and gynecological products has lost about 1/3 of its medical review staff and the malignant heme group will lose about 2/3 of its medical review staff—all to voluntary resignations clustered among seasoned reviewers insights.citeline.com/pink-sheet/a...

There should be a cable channel fact checking all the cable news channels and their paid "pundits" in real time

If gifted narrative filmmaker Marwin Gansauge asks, "Can I make a movie about you?", what do you say? More than ever, science communication is desperately needed to convey the importance of research in developing new treatments for patients. Filmed in Vancouver & Dublin youtu.be/YrevpY-DNmw

Is Makary's FDA already heading toward a breaking point? ipscell.com/2025/07/is-m... #stemcells #stemcell #CRISPR what does it mean for the cell and gene therapy field?

How did the pandemic start? I have avoided publicly commenting on this for 5 years. Here's my take as someone who has no stake at all in the game. gidmk.substack.com/p/pandemic-r...

If real facts matter to you

Sign of the times.

A well-placed biotech investor says U.S. policies are straining life sciences startups — and more disruption is coming. www.statnews.com/2025/07/15/b...

Taxing innovation

TFW when UFC is valued > MIT is not AOK

🧵1/3 How discoveries become cures, in a virtuous cycle @pennmedicine.bsky.social - Public investments in biomedical research have an outsized effect, driving new scientific insights, economic growth, and ultimately treatments and cures. #NIH pennmedicine.org/news/how-dis...

🏋️Training Course! The Use of Cell Therapies for Autoimmune Diseases: CAR-T in #Paris Oct 16-17 #immunotherapy #autoimmune #Tcell #tcellrx @isctglobal.bsky.social www.isctglobal.org/workforce-de...

What vaccine skepticism brings👇

After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%. kffhealthnews.org/news/article...

🚨Worse than you think "World’s premier cancer institute faces crippling cuts and chaos" There used to be bipartisan support. Now: -Rat on your colleagues -Silencing the science communicators -A budget to ‘destroy clinical research’ #NCI #NIH #Cancer #cancerresearch www.cnn.com/2025/07/08/h...

Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia. #Tcell #immunotherapy #organonachip 🧪https://www.nature.com/articles/s41551-025-01428-2

There is arguably no compelling proposed mechanism of action whereby specific cells could reasonably be expected to be effective, i.e. cord blood for autism

🚨🚨🚨Big news for development of in vivo CAR T cells: AbbVie (ABBV) to Acquire Capstan Therapeutics for $2.1 Billion @abbvie @capstantx #TCell #tcellrx #immunotherapy www.streetinsider.com/Corporate+Ne...

Too many people recognize their opinions as feelings, but mistake their beliefs for facts. Closed minds hold truths to be self-evident. Open minds are willing to question even strongly held views. Lifelong learning requires the courage to challenge our own convictions.

Private sector, philanthropy can’t replace science cuts. #NIH #CDC #FDA #Science www.statnews.com/2025/06/26/n... via @statnews.com

Unbridled individualism at the expense of community safety and #misinformation on vaccines threatens lives www.statnews.com/2025/06/24/v... via @statnews.com

In #Philly, even the floor robots are #Eagles fans

Analysis: FDA shakeup finally gets key leader Nicole Verdun; bros, politics & AI to rule instead of experienced scientists? ipscell.com/2025/06/fda-... RFK Jr. Oz Makary Prasad Bhattacharya are unlikely to be helpful to biotechs in the cell & gene therapy space #crispr #stemcells

🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease @capstantx.bsky.social direct delivery of mRNA-encoded CARs to CD8+ T cells in mouse & NHP models shows tumor control not only in blood, but also tissue. Immune reset seen at B cell recovery www.science.org/doi/10.1126/...

Some good news coming this afternoon

"A pessimist is one who makes difficulties of his opportunities; an optimist is one who makes opportunities of his difficulties." World War I Soldier, Reginald B. Mansell #QuoteoftheDay h/t Rick Itzkowich🌈

#bio2025 when #cancer #immunotherapy meets #CountryMusic = Ring That Bell, a song I co-wrote w @magsmccarthy.bsky.social is on the Amazon charts Music video on YouTube youtube.com/watch?v=dkOr... / iTunes: itunes.apple.com/us/album/rin... Spotify: open.spotify.com/album/53z1BE...

Matt Herper takes a peek behind the curtain, where all may not be as the PR makes it out to be . . .

What once was a dream, a distant goal, is now bringing hope and saving more souls A Cutting-Edge Cancer Therapy Offers Hope for Patients With Lupus #TCell #immunotherapy #lupus www.nytimes.com/2025/06/18/w...

This month in cell culture culture - Gracie the CAR T-Cell is a young T-cell beginning studies with friends at Thymus Academy to learn what is needed to be active immune cells. #Tcell #immunology #Childrensbooks 🧪🔬https://www.amazon.com/Gracie-CAR-T-Cell-Kathleen-Haines/dp/B0FC9NZ1YL/

“It is so far out of left field that I find it insulting to our members of Congress that they would actually give them something like this. Congress members are relying on these agencies to provide them with valid information, and it’s just not there,” said Dr. Mark Turrentine, an OBGYN professor.

Misguided DOGE Slows Medical Research & Clinical Development

#bio2025 when #cancer #immunotherapy meets #CountryMusic = Ring That Bell, a song I co-wrote w @magsmccarthy.bsky.social is on the Amazon charts Music video on YouTube youtube.com/watch?v=dkOr... / iTunes: itunes.apple.com/us/album/rin... Spotify: open.spotify.com/album/53z1BE...

#EHA2025 when #cancer #immunotherapy meets #CountryMusic = Ring That Bell, a song I co-wrote w ‪@magsmccarthy.bsky.social Music video is out on Amazon, YouTube youtube.com/watch?v=dkOr... / iTunes: itunes.apple.com/us/album/rin... Spotify: open.spotify.com/album/53z1BE...

#EHA2025 when #cancer #immunotherapy meets #CountryMusic = Ring That Bell, a song I co-wrote w ‪@magsmccarthy.bsky.social Music video is out on Amazon, YouTube youtube.com/watch?v=dkOr... / iTunes: itunes.apple.com/us/album/rin... Spotify: open.spotify.com/album/53z1BE...

The proposed deep cuts to the NIH budget will hit biotechs-in fact, the upheaval already is affecting some. In addition to hobbling academia, where innovation starts, it'll shrink the gov seed $ that tiny firms, esp those outside biotech hubs, rely on. My latest @opinion.bloomberg.com (🎁 link):

The U.S. is desperate for doctors, but is turning away international med students. Visa hurdles and residency bottlenecks are leaving future physicians sidelined while the shortage grows buff.ly/z89IpOp