CDK 4/6 inhibitors form the predominant backbone in hormone positive metastatic breast cancer. A summary of its transformative effect on survivals. #mbc #bcsm #oncsky #breast #cancer

My take on the #Top5 🔑 studies presented at #SABCS24 for #VuMedi #bcsm #breastcancer @osucccjames.bsky.social @osuwexmed.bsky.social @sabcs.bsky.social

One of the most common unnoticed electrolyte imbalance in cancer patients - Hypomagnesemia! Do test when indicated by keeping it in your DDx ! Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using: 💊EGFRibs 💉Platins 💊TKIs 💉Anti HER2 #cancer #oncology #oncsky

Antibiotics at increased risk of clostridium difficile infection Must know for every clinician! #basics #pharmacology

Revising FLIPI 1 & 2 in follicular lymphomas Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP ❌ in bendamustine regimens ⚡ EZH2 mutation status -Bendamustine in EZH2 wild type FL -CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS #lymsm #lymphoma #oncsky #basics

Revising FLIPI 1 & 2 in follicular lymphomas Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP ❌ in bendamustine regimens ⚡ EZH2 mutation status -Bendamustine in EZH2 wild type FL -CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS #lymsm #lymphoma #oncsky #basics

Here's a fan #art i made of my favorite #christmas movie! What's christmas without an elf, a dwarf and a magic white bearded grandpa? 😄 Merry Christmas everyone!

4 diagnoses, 4 livers. 1 endless week. Oncology can be pretty darn humbling. Currently in a spiral of existentialism and confronting one's own mortality.

How do immuno modulatory agents work in #myeloma? And why does Pomalidomide work even after progression on lenalidomide? Tumor microenvironment plays a major role in myeloma and pathogenesis. Ikarus Transcription factor is key. #cancer #hemesky #blood #oncsky @nihardesai7.bsky.social

What clinical features should you pick up as an oncologist in a patient receiving systemic therapy? #basics #oncology #oncsky Good to know for medical students and people interested in oncology!

#Liver transplantation criteria for #HCC - Review from the new ASCO guidelines #oncsky #oncology #cancer

#cardio toxicity of CML TKIs, multiple myeloma agents and VEGF blockers. ⚠️ VEGFr blockers need more stringent monitoring than anthracyclines and HER2 targeted Mabs! #cancer #myeloma #oncsky

ICI induced myocarditis ❤️‍🔥 🔬 Patho (EMBx) - Dallas Cx Multifocal inflammatory infiltrates + overt cardiomyocyte loss ⚕️Clinical cTn - new/significant ⬆️⬆️ from baseline - with 1 major/2 minor criteria - Exclude ACS/acute infectious myocarditis #sabcs24 #cancer #bcsm #oncsky #cardio toxicity

Trials supporting Immunotherapy in operable NSCLC Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social #LUNG #cancer #lcsm #oncsky

Management of leptomeningeal disease 💉 Intrathecal therapy ☢️Response assessment criteria 🧬 Promising areas of research ✅ Treatment algorithm #oncology #oncsky #cns

Quiz time! Which conventional chemotherapy agents of the below cannot cross BBB? Capecitabine Platinums Temozolomide Doxorubicin #oncsky #chemotherapy #basics #brain #oncology Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.

Pearls of #myeloma wisdom from @vincentrk.bsky.social Quick review algorithm - for transplant eligible and relapsed myeloma #ash24 #heme #hemonc #oncsky

LEAP program - Lenva and Pembrolizumab in solid tumors A comprehensive list of LEAP group trials A summary of site-wise response rates and PFS Interesting paper! #oncology #oncsky #lcsm www.tandfonline.com/doi/full/10....

⚡ Doses and indications of lenvatinib - for all FDA approved indications. Along with dose reduction levels A quick reckoner Common Tox: ☢️Diarrhea ☢️Asthenia & mucositis ☢️Proteinuria & HTN ☢️Rash and PPE #oncsky #chemotherapy #basics #oncology

@vincentrk.bsky.social Welcome to bluesky, my favorite myeloma/hematology teacher 🙏

Was brushing up a bit about myelodysplastic syndromes. Came across a concise & brilliant article by Dr Garcia Manero - must read! Prognostication, cytogenetics in MDS, the MDS spectrum, treatment algorithms and the IPSS stratification. #heme #hemonc #oncsky

Opinion: Colostomy free survival would be a very good surrogate marker of QOL for ca rectum. Especially with so many younger patients these days. Their HRQOL and sexual QOL will also come into play with locoregional recurrence. Organ preservation should be our next great frontier. #oncsky #cancer

TCGA - Gastric Ca Molecular Classification 👁️ EBV - best outcomes following resection, notably absent in GEJ ❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse 🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️ Snapshot of targeted therapies for Gastric adenoca #gi #gastro #cancer #oncsky

A comprehensive review of evidence supporting EGFR inhibitors in NSCLC ✅ Neoadjuvant - EMERGING ✅ Adjuvant - ADAURA ✅ Unresectable - LAURA ✅ Metastatic - FLAURA, PAPILLON, ACHILLES ✅ Resistant(on vs off target) - MARIPOSA2, HARMONI, immunorx #lung #cancer #lcsm #oncsky

👑 RCHOP remains king/queen in limited stage DLBCL. ✅ PET adapted therapy - best for assessing risk groups for recurrence. ✅ Polatuzumab - better for Non GCB subtype and elderly subgroup - at the cost of increased neuropathy ☢️RT if decreased chemo tolerance ⬇️ #lymphoma #oncsky #heme #cancers

I've never related to anything more 🙏

Patterns of meningeal metastases with radio DDx and spotters 🧠 Pachymeningeal - dural mets - MC - breast, prostate, and lung cancers 🧠Leptomeningeal - pia and arachnoid - MC - breast, lung, melanoma #cancer #oncsky #brain #metastasis #radiology Pic credits : Radiology Assistant

I also did a thing pretty recently I’m pretty proud of 😊 Having people send me photos from Barnes & Noble across the country has been incredibly surreal and makes my day every time. THANK YOU I donate my portion of the proceeds from TOO YOUNG FOR CANCER. www.amazon.com/gp/aw/d/1639...

When to avoid concurrent PPIs in #cancer treatment? - antimetabolites - immunorx - TKIs Although there is lack of strong randomised data re the same, retro data has shown diminishing efficacy with concurrent PPIs What is the alternative? #oncsky #chemotherapy #basics #oncology

Anthracyclines and conversion factor #oncsky #chemotherapy #basics #cancer

Basic mutational testing required for management of #lung #cancer #lcsm Compiling ASCO/NCCN/ESMO guidelines A crisp summary

This is how we should be doing Oncology trials - the Dutch SONIA trial looking at treatment sequencing of CDK 4/6 inhibitors in advanced breast cancer. A self funding efficiency trial! #oncsky www.nature.com/articles/s41...

#ESMO resources from HRR - HRD testing in #ovarian #cancer Along with evidence for #PARPi utility in ovarian cancer #gyn #gcsm ✅Telomeric allelic imbalance, ✅loss of heterozygosity, ✅large scale transitions - form a genomic scar score/instability score >42 significant Myriad score.

Combination approaches for checkpoint inhibitors - #immunotherapy #cancer #oncsky Very good review article by @pamsharmamdphd.bsky.social

Very good, concise summary of the gut-brain axis of communication and interoception www.cell.com/current-biol... open-access

Been thinking a lot lately about that episode of Parks and Rec where Leslie and Tom have to rebrand fluoride in the water as TDazzle in order to get the public to support it.

⭐️Development and phenotype of regulatory T cells This picture is worth 100 K words! Link to pdf: www.stemcell.com/media/files/...

Why do we give Prednisone with Abiraterone in #prostate #cancer? #GU #oncsky #oncology

The hallmarks of cancer immune evasion

#colon #cancer screening simplified, courtesy NCCN For general population, multiple guidelines suggest starting screening at 45-50y. Even though it's a literal pain in the @ss, colonoscopy remains standard of care till fecal/blood tests gain prominence. #gicsm #gastrointestinal #oncosky #oncsky

What constitutes a response in #cml ? a brief overview of the international scale for molecular response, based on the BCR ABL quantitative assay. Also an algorithm for management of cp-cml based on #NCCN and #ELN guidelines. #hemonc #cancer #oncksy #oncology

An interestingly named GOZILA study - based on ctDNA sequencing. Has some fascinating data on the molecular landscapes of gastrointestinal tumors. #gastro #cancer #gitcsm #gicsm #gi www.nature.com/articles/s41...

Just wanted to show off some of my favorite older #artwork pieces, to sneakily gain entry into #artsky along with oncsky :) I do whimsy and portraits usually 😅

#Oncology NEW Review explores the marked increase in #cancer in young people over the last few decades. Includes multiple hypotheses about why we’re seeing this & methods to test them. #OncoSky #MedSky #bcsm #crcsm #ayacsm #melsm #kcsm #pancsm #thyroidcancer www.cell.com/action/showP...

Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!

New rapid recommendation update on systemic therapy for small-cell lung cancer from ASCO just published: ascopubs.org/doi/full/10.... #ASCOguidelines #MedSky #OncSky #LCSM

Updated treatment algorithms for breast cancer now include adjuvant ribociclib and inavolisib, along with key trial names. Thrilled to see we're truly running out of space in HR+ disease—progress is here, with much more to come for all breast cancer subtypes!

Immunotherapy inclusion criteria in high risk renal cell carcinoma - Ph3 trials summary #cancer #immunotherapy #kidney

Palliative care is critical in the patient-centered comprehensive oncologic practice