#SABCSSnippets: Marcela Mazo talked with Marjolein Smidt at #SABCS25 about the results of the Phase III BOOG 2013-08 trial, which indicate that sentinel lymph node biopsy may be safely omitted in some patients with early-stage breast cancer. buff.ly/MrXAKvF

#SABCSSnippets: Saba Shaikh talked with Sonia Pernas at #SABCS25 about the Phase II SUMIT-BC trial, which showed that the CDK7 inhibitor samuraciclib + fulvestrant showed efficacy in HR+ metastatic breast cancer patients previously treated with a CDK4/6 inhibitor. buff.ly/gkjdRPf

Ruth O'Regan summarizes the 2025 FDA approvals for HR+ metastatic breast cancer, including datopotamab deruxtecan, trastuzumab deruxtecan, and imlunestrant. Watch now in the Best of #SABCS25: buff.ly/vDfAHmH

#SABCSSnippets: Rahul Gosain of the Oncology Brothers talked with Marleen Kok at #SABCS25 about how lobular carcinoma—which comprises 10-15% of all invasive breast cancers—differs from ductal carcinoma. buff.ly/r4mA3Vx @marleenkok.bsky.social @oncbrothers.bsky.social

Hope Rugo reviews biomarker subgroup results from the evERA phase III trial, updated EMBER-3 efficacy of imlunestrant in advanced breast cancer, and WISDOM 1.0 findings on risk-based screening. Watch now in the Best of #SABCS25: buff.ly/vDfAHmH @hoperugo.bsky.social

Hope Rugo shares the first positive results for an oral SERD (giredestrant) in the adjuvant setting and key findings from the phase III lidERA trial in ER+, HER2− early breast cancer. Watch now in the Best of #SABCS25: https//buff.ly/fUHtwnq @hoperugo.bsky.social

#SABCSSnippets at #SABCS25: Julie Nangia and @ErikaHamilton9 discussed HER2CLIMB-05, which showed that adding tucatinib to 1st-line maintenance therapy with trastuzumab and pertuzumab delayed progression in patients with HER2+ metastatic breast cancer. buff.ly/YIwYQEh @erikahamilton9.bsky.social

Janice Tsang reviews a year in metastatic breast cancer, highlighting key trial updates in TNBC, HER2+ and HR+/HER2− disease—including ASCENT, DESTINY-Breast, HER2CLIMB, EMBER-3 and SERENA-6. Watch now in the Best of #SABCS25: buff.ly/vDfAHmH

William Gradishar reviews key #SABCS25 findings in early breast cancer, including neoadjuvant trials TBCRC056 and OlympiA exploring PARP inhibitors and immunotherapy in BRCA-mutated disease. Watch now in the Best of SABCS®: buff.ly/vDfAHmH

#SABCSSnippets: Virginia Kaklamani talked with Hope Rugo at #SABCS25 about the field of endocrine therapy, including data from the Phase III evERA Breast Cancer Study and from the Phase II ELEVATE Study. buff.ly/Bw3mSWW @vkaklamani.bsky.social @hoperugo.bsky.social

#SABCSSnippets: Virginia Kaklamani talked with Laura Esserman about the results of the WISDOM 1.0 study, which demonstrated that risk-based breast cancer screening is safe, preferred by women, and identifies the highest risk individuals. buff.ly/DFByGvB @vkaklamani.bsky.social

Close out #SABCS25 with the Year in Review and View from the Trenches sessions on Friday afternoon. More details in SABCS Meeting News: buff.ly/NMwi7Nk

Experts will explore whether all patients with early-stage breast cancer need axillary staging during an #SABCS25 debate on Friday afternoon. Learn more: buff.ly/dsX3CkF

Sara M. Tolaney, MD, MPH, AACR Outstanding Investigator Award for Breast Cancer Research recipient, will present an award lecture on Friday afternoon at #SABCS25. Read more: buff.ly/Dnsf4Rd

Friday's Poster Spotlight Sessions at #SABCS25 covered a wide range of topics, including the application of AI to pathology and risk stratification, locoregional challenges, and CNS metastases.

#SABCS25 Patient Advocacy Spotlight: Marcela Mazo Canola, MD, and Laurel Pointer reflect on their relationship as physician and patient. Read now in SABCS Meeting News: buff.ly/84wgwzX

Real Impact with Artificial Intelligence: Johan Hartman, Tufia Haddad, Amrita Basu, and advocate Carole L Baas explored this topic in an #SABCS25 educational session moderated by Frederick M Howard.

Elie Rassy, Gustavo Werutsky, Sara Tolaney, and advocate Janice Cowden discussed "How to Treat TNBC" in an #SABCS25 educational session moderated by Marleen Kok.

Patients are at the heart of the SABCS mission. We thank our patient advocate attendees for their enthusiastic participation in the Symposium and for their critical contributions to the #SABCS25 program.

Targeting the Non-T Cell Microenvironment: Fatima Mechta-Grigoriou, Kelly Kersten, George Plitas, and advocate Cheryl Jernigan addressed this topic in an #SABCS25 State of the Art session moderated by Christos Sotiriou.

Management of the Axilla in Multidisciplinary Care: Giacomo Montagna, Lori Pierce, Sherry Shen, and advocate N. Beth Emery addressed this topic in an #SABCS25 Clinical Controversies session moderated by Tari A. King. @sherryshenmd.bsky.social

Patient advocate Marissa Thomas, CEO of The Breast of Us, will speak during a Friday afternoon session at #SABCS25 on body image, hair loss, and skin health after cancer treatment. Learn more in SABCS Meeting News: buff.ly/kVLAcSv

Wendy Woodward and François-Clément Bidard moderated today's General Session at #SABCS25. The clinical trials featured in the session included TBCRC-053, Alliance A011104/ACRIN 6694, and BOOG 2013-08. @ibcradiation.bsky.social

Partnership for Progress: #AACRFellows Dennis Slamon joined Debra A. Patt and Barbara Segarra-Vazquez to discuss the role of advocacy in breast cancer research and treatment during a special plenary lecture this morning at #SABCS25.

Another day of great science—including sessions on optimizing cardiac outcomes and treatment of triple-negative breast cancer, and the @theaacr.bsky.social Distinguished Lecture in Breast Cancer Research—will begin soon at #SABCS25.

Representatives from more than 25 patient advocacy organizations discussed their work with #SABCS25 attendees in the Patient Advocacy Pavilion during the exhibit show on Wednesday. The Pavilion remains open through Friday during exhibit hours.

As part of the Alamo Advocate Program, an AACR session featured co-moderators Dr. Fatima Cardoso and Teri Pollastro, keynote Dr. Marianna Chavez MacGregor, and panelists Abigail Johnston and Kirstin Spencer who discussed how to demystify patient involvement in research.

Sibylle Loibl, Reshma Mahtani, Andrew Brenner, and advocate Rosa Olmos discussed "Antibody-Drug Conjugates in the Clinic" during an #SABCS25 educational session moderated by Adrienne G. Waks. @mahtanimiami.bsky.social

Management for Predisposition Gene Carriers: Tuya Pal, Fergus J Couch, Stephanie M Wong, and advocate Brianna Wesley-Majsiak addressed this topic in an educational session moderated by Susan Domchek. #SABCS25

Jonathan Strauss, Icro Meattini, Tari A. King, and advocate Marylinn Minor discussed "Optimizing De-escalation in Low-Risk HR+ Early-Stage Breast Cancer" in an educational session moderated by Mylin Torres. #SABCS25

Melissa Southey, Allison Kurian, Laurent Briollais, and Jeanine Genkinger highlighted the evolution and ongoing impact of the Breast Cancer Family Registry during a special #SABCS25 session moderated by Mary Daly. @genkjeanine.bsky.social

Attendees engaged with poster presenters this afternoon during the opening poster session at #SABCS25.

ADCs: Targeted Therapy or Chemo? Dennis Sgroi, Sarat Chandarlapaty, and Sara A Hurvitz debated this question in a Translational Controversies session moderated by David Rimm. #SABCS25

A panel of physicians and an AI model presented by Mohammad Jahanzeb each evaluated a patient case and recommended a treatment plan, and panelists compared the results during a special #SABCS25 Clinical Case Discussion moderated by Harold Burstein.

Moderators Stefan Glück and Rita Nanda welcome #SABCS25 attendees to today's General Session. The session showcases the results of several phase 2 and 3 clinical trials, including Her2climb-05, ASCENT-07, and lidERA. @ritanandamd.bsky.social

The Bumpy Road to Progress: Changes in the Management of the Axilla—Armando E. Giuliano delivered the William L. McGuire Award Lecture this morning at #SABCS25.

Symposium co-directors Virginia Kaklamani and Carlos L. Arteaga welcome attendees to the 48th annual San Antonio Breast Cancer Symposium. #SABCS25

Presenters share the latest cutting-edge research—including data from the ALTERNATE, I-SPY, and MARRES trials—during a Rapid Fire session at #SABCS25.

Nolan Priedigkeit and Frederick Howard presented Rising Stars Award Lectures this afternoon in a special session at #SABCS25.

@maryamlustberg.bsky.social highlights the major unmet needs in #menopause care after #breastcancer at #SABCS25. “Our patients have a lot of symptoms and they are not always being addressed — we need to do a lot better.” @sabcs.bsky.social

Balancing Act: Hormone Replacement Therapy in Breast Cancer Care— Maryam Lustberg, Juliana Kling, Lisa Larkin, & advocate Thelma P. Brown addressed this topic in an #SABCS25 educational session moderated by Tana Sanft. @maryamlustberg.bsky.social @lisalarkinmd.bsky.social @drjewelk.bsky.social

Best of AACR 2025: #AACRFellows Charles M. Perou and Carlos L. Arteaga moderated an #SABCS25 educational session that featured high-impact #AACR25 presentations from Paul S. Mischel, Piro Lito, Yun Yan, and Kenichi Shimada. @kenichi-shimada.bsky.social

Executive and Leadership Coach Anne Welsh discussed the four roots of compassionate leadership—Resilience, Reach, Recognition, and Respect—in a career development session on "Compassionate Leadership" at #SABCS25.

Liquid Biopsy in Breast Cancer, Bridging Technology and Clinical Practice—Maximilian Diehn, Pedram Razavi, Alexandra M. Miller, and advocate Judith Ann Fitzgerald addressed this topic in a Translational Workshop this afternoon at #SABCS25.

Visit the SABCS Store in the main lobby to pick up SABCS-branded gear, including shirts, key chains, mouse pads, and #SABCS25 mascots Shelly the Armadillo and Bruno the Bull! All proceeds fund scholarships for early-career researchers—including 2025 awardee Yuliya Zektser.

Career Development for Enhanced Research and Community Impact—Brenda Ernst, Dawn Hershman, Clifford Hudis, Derek Rodriguez, and Sarah Premji addressed this topic in a career development session at #SABCS25.

#SABCS25 is underway! Julia Palmer, Mary Beth Terry, Kristy Brown, and advocate Stacey Tinianova discussed alcohol consumption, genetics of alcohol metabolism, and obesity during a special session on lifestyle factors and breast cancer risk moderated by Seema Khan.

Leif Ellisen, MD, PhD, will moderate a Translational Workshop on advances in spatial omics at #SABCS25. Read a preview in SABCS Meeting News: buff.ly/swYtzxh

During an #SABCS25 Plenary Lecture, Joan Brugge, PhD, will review findings that provide insights into BRCA1/2-mediated tumorigenesis. Learn more in SABCS Meeting News: buff.ly/AJPP2mk

Anne Welsh, PhD, will share leadership strategies during the #SABCS25 career development workshops. Read a preview in SABCS Meeting News: buff.ly/Xtx1VJZ