Marleen Kok, MD PhD, NKI
@marleenkok.bsky.social
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Breast Oncologist and translational researcher @nki, Immunotherapy and immune cell lover, Mother, 🍀🌿
More than proud to be working
@nkinl.bsky.social
under the great leadership of
@thijnbrummel.bsky.social
. His achievements in the field of fundamental sciences ✍️🔬are truly amazing! Congrats Thijn🥳
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3 months ago
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reposted by
Marleen Kok, MD PhD, NKI
ESMO - European Society for Medical Oncology
5 months ago
#ESMOBreast25
: Low baseline tumour infiltrating lymphocytes
#TILs
and nodal involvement may predict
#BreastCancer
patients with poor prognosis despite pathological complete response to neoadjuvant chemotherapy.
#ESMODailyReporter
has more 🔗
buff.ly/YmxaCJ7
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I just learned a new pathologist joke: “Tumors dont read J Clin Oncol” from Beppe Viale cited by Carsten Denkert. 🧐📔We as researchers oversimplify cancer biology but tumors dont always follow our classifications
@myesmo.bsky.social
#esmoambassadors
#esmobreast25
5 months ago
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Thanks to Nadia Harbeck 🙏for the following extremely important remarks: 1) we shouldnt aim for using even 2 gene expression test, one expensive test is enough; 2) instead use a dynamic biomarker: Ki67 drop after endocrine tx.
@myesmo.bsky.social
#esmoambassadors
#esmobreast25
5 months ago
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reposted by
Marleen Kok, MD PhD, NKI
Philippe Aftimos, MD
5 months ago
An enthusiast and militant talk by
@marleenkok.bsky.social
at
#ESMOBreast25
on the importance of studying biomarkers for immunotherapy in breast cancer, highlighting the KN522 example
#ESMOAmbassadors
@myesmo.bsky.social
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reposted by
Marleen Kok, MD PhD, NKI
Philippe Aftimos, MD
5 months ago
The path forward for immunotherapy biomarkers in breast cancer by
@marleenkok.bsky.social
#ESMOBreast25
#ESMOAmbassadors
@myesmo.bsky.social
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Really impressive talk by Davide Massa on prognostic value of TILs together with nodal status in patients with TNBC and pCR. Outcome for TIL low and cN+ is not that good. Would additional treatment help?
@myesmo.bsky.social
#ESMOBreast25
#ESMOAmbassadors
5 months ago
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Do you want to know the most recent ins and outs in breast cancer research and treatment? Follow us 👇for the coolest news from
#ESMOBreast25
#BCSM
@myesmo.bsky.social
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5 months ago
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reposted by
Marleen Kok, MD PhD, NKI
ESMO - European Society for Medical Oncology
6 months ago
📢
#ESMOFellowship
applications are now open! The Society is committed to supporting
#YoungOncologists
in developing high-quality
#TranslationalResearch
and
#ClinicalResearch
projects. 📅 Apply by: 29 May 2025 🔗
buff.ly/NN5Y1ol
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Very very proud of you my friend. You are a star and fantastic scientist!
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6 months ago
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Please donate!🚵🏽♂️💵💰 Last year we received a huge grant 🤩from KWF to launch the internat OPTImaL trial to avoid chemo for low stage BC with many immune cells! We strongly feel that we should do something in return for KWF so we will bike 🚵🏽♂️the Alpe d’Huez 💪🏼
www.opgevenisgeenoptie.nl/fundraisers/...
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Marleen Kok
Ik doe mee aan Alpe d’HuZes omdat ik geloof dat wij samen kunnen werken aan een wereld waarin je niet meer doodgaat aan kanker, wil jij mij steunen?
https://www.opgevenisgeenoptie.nl/fundraisers/MarleenKok30307/alpe-dhuzes
6 months ago
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Very good talk by famous statistician
#SGBCC2025
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7 months ago
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Thanks
@drsgraff.bsky.social
for your amazing report of -again- an amzing session
#SGBCC2025
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7 months ago
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With co-director
@vkaklamani.bsky.social
of
@sabcs.bsky.social
we have been working on
#SABCS25
program! Stay tuned! Super exciting with stellar line-up of speakers. With
@heidefordlab.bsky.social
@itsnotpink.bsky.social
and many other fantastic faculty members
#bcsm
7 months ago
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Good to see your here
@renemedema.bsky.social
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7 months ago
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Looking forward to work as senior editor for the
@theaacr.bsky.social
journal Clin Cancer Res with this 👇 amazing editor-in-chief. Congrats Tim Yap!
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8 months ago
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We are hiring!
www.nki.nl/careers-stud...
@nkinl.bsky.social
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Bioinformatician in Breast Cancer Immunology | Netherlands Cancer Institute
https://www.nki.nl/careers-study/vacancies/bioinformatician-in-breast-cancer-immunology/
8 months ago
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Important editorial in the
@thelancet.bsky.social
Wrong decisions endanger Health care in the US and worldwide, especially for people who need it the most! Lets unit and speak up!📣
www.thelancet.com/journals/lan...
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American chaos: standing up for health and medicine
Withdrawal from WHO and the Paris Agreements. USAID shuttered and aid halted, ceasing health programmes globally. A freeze on US$3 trillion worth of federal grants and loans, jeopardising the function...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00237-5/fulltext
8 months ago
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reposted by
Marleen Kok, MD PhD, NKI
E John Wherry
8 months ago
This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this?
grants.nih.gov/grants/guide...
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NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-068.html
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very important (but negative) trial on cdk46i in mTNBC. huge shout-out to
@stolaney1.bsky.social
and Shom Goel for conducting this trial👍
@oncoalert.bsky.social
#bcsm
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8 months ago
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Many good things to say on this story
@oncoalert.bsky.social
@naturemedicine.bsky.social
: 1) serious biomarker work from a pharma-sponsored trial👏👏 2) a tumor historically consid cold 🥶can respond to aPD1 🤩3) we need to redefine ER+ disease to enable personalized treatm✍️
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8 months ago
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Impressive paper on biomarkers for immunotherapy in RCC! Good to see biomarkers from pharma-sponsored clinical trials!
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9 months ago
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Interesting paper on neo-antigen specific T cell therapy! Congrats Cell Therapy team
@nkinl.bsky.social
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9 months ago
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reposted by
Marleen Kok, MD PhD, NKI
Jon Lim, MRCP PhD
10 months ago
Big fan of the concept of immunogenic cell death/inducing immunogenicity with 'conventional' therapies - so really looking forward to reading/hearing more about TONIC2 following the nice work from the original TONIC trial by
@marleenkok.bsky.social
& team
@nkinl.bsky.social
👇
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Smart analyses approach in immunotherapy trials
#SABCS24
with stellar 🤩 scientists
@christinedesmedt.bsky.social
@lambrechtslab.bsky.social
C. Sotiriou, R. Ali and E. Romero
10 months ago
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Great start
#SABCS24
with session on Dietary Suppl, Sex, Exercise ‘Sex, Drugs and Rock n Roll’ 💊🍺❤️🏃🏽♂️➡️with funny joke by
@drdonsdizon.bsky.social
that his talk will be a ‘quickie’🤣
10 months ago
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Exciting to present 🎤 new data
#SABCS24
from TONIC2 study, follow-up from
rdcu.be/d22kf
. Do immune inductions using low dose dox or cisplatin indeed benefit pts? See us at P1-7-30 and during PS17-9 we show data on TME during acquired resistance to aPD1. With V. Geurts
@nkinl.bsky.social
@oncoalert
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Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial
Nature Medicine - A pick-the-winner clinical trial design in patients with metastatic triple-negative breast cancer shows that immune induction with doxorubicin or cisplatin may improve clinical...
https://rdcu.be/d22kf
10 months ago
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#SABCS24
is a good test who and how many breast cancer research folks decided wisely to move to from X to
@bsky.app
🧐. Looking forward to lively comments on the exciting new data we will see in the coming days
@oncoalert.bsky.social
@oncbrothers.bsky.social
@oncodaily.bsky.social
10 months ago
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reposted by
Marleen Kok, MD PhD, NKI
The OncoAlert Network 🚨
10 months ago
Welcome to
#SABCS24
Faculty🚨
@erikahamilton9.bsky.social
@hoperugo.bsky.social
@drsgraff.bsky.social
@maryamlustberg.bsky.social
@raalbany.bsky.social
@elisaagostinetto.bsky.social
@elisabettabonzano.bsky.social
@stolaney1.bsky.social
@fernandoonco.bsky.social
@coffeemommy.bsky.social
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Recent Nature paper on phase of menstrual cycle at start of breast cancer chemo suggests that this can affect chemo-sensitivity. More research needed on how this can result in cycle-driven-chemo-start. 💊💉Congrats @vanRheenen_Lab @NKI_nl
rdcu.be/d2p2l
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The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy
Nature - In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during...
https://rdcu.be/d2p2l
10 months ago
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The PhD program
@nkinl.bsky.social
is excellent! NKI is the place to be for top-notch cancer research while working in a fantastic open and friendly atmosphere👇
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10 months ago
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reposted by
Marleen Kok, MD PhD, NKI
Elisa Agostinetto
11 months ago
The results of the SONIA trial on the early vs deferred use of CDK4/6i in advanced breast cancer are now published in @Nature No statistically significant benefit for the use of CDK4/6i as a first-line compared with second-line treatment
@oncoalert.bsky.social
www.nature.com/articles/s41...
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Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature
The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.
https://www.nature.com/articles/s41586-024-08035-2
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Insightful translational study on chemo+IO in eTNBC dissecting chemo response vs IO response! Well done GBG!
@cellpressnews.bsky.social
#bcsm
@oncoalert.bsky.social
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11 months ago
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