Viewpoint: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/... #Organelles #Development #Metabolism

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Fantastic study #gut is central to our #health

The gut-brain connection Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.

Cell signalling milestones from #Biochemicaljournal. Must 👇👇👇 x.com/biochem_jour...

I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky

Exciting times, a study shows organ specific #aging and future #disease can be measured. x.com/hammy_oh/sta...

Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...

www.nature.com/articles/s41... “Vaccines have saved 154 million lives globally since the launch of the Expanded Programme on Immunization by the World Health Organization in 1974 and are one of the great triumphs of medicine”

One more obstacle on the way CD4+ T cells unleashed 👇 Neuropilin 2

Very awed by the incredible work @chrischirp.bsky.social is doing and delighted to see this profile

Maladaptive #Trainedinnateimmunity in chronic inflammation and cancer 👇👇👇

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out! We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections! www.nature.com/articles/s41...

This one is particle uptake via #phagocytosis which programs unique set of transcriptional response in #macrophages

Soluble antigen #crosspresentation by #macrophages in CD8 T cell priming 🫣

#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!

"We should include eugenics in our undergraduate classes, reminding students that scientists must speak out when others lie about science and use it to further their political views," says professor @peiferlabunc.bsky.social. www.cell.com/trends/genet... @cp-trendsgenetics.bsky.social

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13 onlinelibrary.wiley.com/doi/10.1111/...

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

The threat to science from all corners is everywhere and we must all defend logic and truth in the most beautiful way possible and that is science

Many wonders of aspirin 👍

What more exciting than looking forward to the EMBL Events meetings in 2025!

Selective targeting of #PI3K activity is becoming more real 👇👇👇 www.biorxiv.org/content/10.1...

Treg maintenance also matters! 👇👇👇

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

Highly provocative science. Well done!

The danger theory of immunity strikes back... rdcu.be/d1uQN

Resilence in the gut by compartmentalising microbiota. www.nature.com/articles/s41...

Aren’t we familiar with this? x.com/itaiyanai/st...

Excellent paper, showing going back to the origins might be the clue in anti-inflammatory therapies www.science.org/doi/10.1126/...

A Ludwig Oxford study punctures a longstanding assumption about the source of the genome's most common type of mutation. Its findings have implications for our understanding of not only cancer biology but also carcinogenic risk & drug resistance. bit.ly/3Y4bDsZ

Now in the Guardian too www.theguardian.com/technology/2...

Respect/beware of His tags

A study in Nature Human Behaviour suggests that the introduction of mandatory calorie labels in out-of-home food outlets in England was not associated with fewer calories being purchased or consumed. https://go.nature.com/3ZjqYYh

So here’s the update. The billionaire owner of the Guardian preparing to get rid of a core part of the news org + 100 journalists. If you’re a Guardian or Observer reader, please share this. The need for a strong, free & independent press couldn’t be greater. Yet, here it is.

GLUT4 glucose transporter, is a top intervention that improves the function of old Neural Stem Cells. www.nature.com/articles/s41...

Lysosomal membrane localisation keeps mTOR catalytically active. x.com/thehurleylab...

Great Team and Great Mentor 👇👇👇

Interesting concepts. Fueling the fire of adipose thermogenesis Specialized fat tissue generates heat and holds the potential to counter metabolic diseases I wonder what would be the impact on the #immunesystem. 🤔 Jul. 19, 2023 www.science.org/doi/10.1126/...

Great to see another Stanford colleague here in the sky! @sergiuppasca.bsky.social

🚨 I want to gather all artists working in Biology, Cell Biology, or Molecular Biology illustration If you know any artists who create this kind of work, let me know so I can add them here. Drop a comment to join! 💬 go.bsky.app/KWAeJxp

Agreed. Isn't it counter productive to share your science content primarily in the other place, where your message is surrounded by disinformation, conspiracy theories and anti-science? bsky.app/profile/podd...

The metaphors of artificial intelligence www.science.org/doi/10.1126/...

Secret life of RA and TGF beta. Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency www.cell.com/immunity/abs...

@redspottedollie.bsky.social well come to #Bluesky