Le Xiong
@lexiong.bsky.social
π€ 30
π₯ 133
π 4
Mucosal Immunology PhD candidate @WEHI
reposted by
Le Xiong
International Union of Immunological Societies
3 months ago
Introducing Andy Gao, postdoctoral fellow at John Curtin School of Medical Research, ANU! He will present his research on T & B cell collaboration in vaccination & parasite infection at #IUIS2025, with the presentation "Can a B cell eat a parasite? π¬π
https://loom.ly/CwagY2g
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reposted by
Le Xiong
Cyril Seillet, PhD
4 months ago
π PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 𧬠Single-cell RNAseq π¬ 3D imaging π§ Neuro-immune interactions π₯ Great mentoring & collaborations Apply now π
tinyurl.com/Seilletlab
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Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
https://tinyurl.com/Seilletlab
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Congratulations !!!
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4 months ago
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reposted by
Le Xiong
WEHI (The Walter and Eliza Hall Institute of Medical Research)
5 months ago
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health. Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint
#chronicinflammation
at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
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Excited to see our work published on
@cp-immunity.bsky.social
. Also shared by a nice commentary. really like the last sentence: βNot all fuel nourishes; some, once ignited, may burn beyond control.β
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5 months ago
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Le Xiong
Ivan Zanoni
6 months ago
#WeekendRead
!
#NotAllFatIsEqual
!
@lexiong.bsky.social
Seillet &co show
@cp-immunity.bsky.social
that
#diet
saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!
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Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong etΒ al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00136-0
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reposted by
Le Xiong
WEHI (The Walter and Eliza Hall Institute of Medical Research)
5 months ago
Future vaccines a step closer. Research from
@groomlab.bsky.social
,
@benjbroom.bsky.social
and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination. Published in
@jem.org
www.wehi.edu.au/news/vaccine...
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Thrilled to share our work now published on
@cp-immunity.bsky.social
. Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
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6 months ago
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reposted by
Le Xiong
Benjamin Broomfield
7 months ago
Happy one week of my
@jem.org
paper! Our work from the
@groomlab.bsky.social
at
@wehi-research.bsky.social
identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
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Le Xiong
Journal of Experimental Medicine
7 months ago
@benjbroom.bsky.social
et al.
@groomlab.bsky.social
show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cellβlike memory CD8+ T cells
rupress.org/jem/article/...
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