Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...

Compelling metabolic benefits of semaglutide over 30 weeks in patients with schizophrenia Rxed with second-generation antipsychotic agents jamanetwork.com/journals/jam...

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social

The new metabolic medicines #T2D #obesity and #inflammation www.cell.com/trends/endoc...

Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort doi.org/10.1016/j.te...

Delighted to have our latest paper now online in Stem Cell Research & Therapy rdcu.be/ezDs3 Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...

🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk. 📖 Read the open-access study: https://bit.ly/40kBiiH By @andrea-woodcock.bsky.social‬ et al. ##Immunology

Couple of months into our new social media experiment and we are blown away by the engagement - over 2.6 million views on TikTok alone and the daily feedback both online and in person has been so positive and supportive! A whole new way of spreading research based info vm.tiktok.com/ZNdSrMT71/

Our lab @obesityimmunology.bsky.social is looking to support a stellar scientist in their application to the Marie-Sklodowska-Curie European or Global Fellowship to join us to unravel the impact of obesity on the immune system - DM or email [email protected] for details europa.eu/!B8hjh3

En route home from @kingscollegelondon.bsky.social after 2 days of fantastic science chats! Huge thanks to @peruchalab.bsky.social for the invite and hospitality. Hopefully lots of new collaborations

Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.

More evidence for GLP-1 medications in limiting rates of cancer. "The findings of this cohort study suggest that GLP-1RAs are associated with reduced risk of developing several hematologic cancers in patients with T2D" jamanetwork.com/journals/jam...

At the Irish Coalition for People living with Obesity's (ICPO) book launch - a child friendly non-stigmatizing introduction to what is Obesity - great initiative

For my immunology followers, the cantrell lab is on bluesky. Applied proteomics, immunometabolism, T cells, protein degradation, signalling what more could you ask for? Give them a follow: @cantrell-lab.bsky.social

Very latest work from @lindavsinclair.bsky.social out today in Nature Immunology www.nature.com/articles/s41...

Changes in body composition following tirzepatide treatment in a substudy of participants from the SURMOUNT-1 trial; the change in body weight, fat mass and lean mass from baseline to Week 72 was −21.3%, −33.9% and −10.9%, consistent across subgroups dom-pubs.onlinelibrary.wiley.com/doi/full/10....

🚨 new paper alert!! Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection academic.oup.com/discovimmuno...

Great new paper from Sandberg group @ki.se in @pnas.org showing IL-10 producing MAIT cells - a population negatively regulated by IL-18 www.pnas.org/doi/10.1073/...

Brilliant presentation from @ArdenaBeirsha from our lab today at #IGCT25 conference @maynoothuni.bsky.social

Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo. Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo) If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...

New arrivals from X so thought we'd share our most recent paper where we show GLP-1 analogue therapy in people with obesity increases metabolic activity but only in those who loose weight - adding increased energy burn to increased satiety as a mechanism of action doi.org/10.1002/oby....

Delighted to say I have been promoted to Professor - huge thanks to all my lab members present and past - its their hard work and talent that made this happen

This week @eimearrryan.bsky.social from our lab will present the second story from her PhD (only started year 3!) on human MAIT cells metabolism

Shocking investigative piece by #RTEprimetime aired tonight on the black market supply of GLP-1 medications in Ireland - from smuggled pens to clear glass vials with no labels www.rte.ie/news/investi...

www.nature.com/articles/s42... New studies identifying the local inputs to AgRP neurons, reveals a circuit through which GLP-1RAs suppress appetite

Could we see a once a month GLP-1 therapy in the future? Lipidation of semaglutide increased its availability to 36 days and allowed for lower dosing in mice - would further increase its accessibility to people living with obesity! www.pnas.org/doi/10.1073/...

New CD1MR1 Immunology Society is launching with a webinar series on December 3rd, 3pm - 4pm (UTC+1). I'm delighted to be talking about #MAITcells at the first one along with @barrallab.bsky.social (iNKTs) Forward your email & I'll send to S.A.B to be added to the mailing list for the zoom links

Do GLP-1 therapies reduce alcohol intake? Secondary analysis of an RCT participants taking dulaglutide compared to placebo were 29% more likely to reduce alcohol intake. Not conclusive but maybe? www.thelancet.com/journals/ecl...

Obesity imprints adipose tissue even after weight loss - promoting regain and progression. Same is observed with GLP-1 therapies were we see regain in the majority of individuals who stop TX www.nature.com/articles/s41...

More data supporting the cardio protective effect of GLP-1 targeted therapy (this time Tirzepatide led to a lower risk of death from cardiovascular causes or worsening heart failure than placebo www.nejm.org/doi/full/10....

Quick discussion on Ozempic from this weeks RTE drivetime www.rte.ie/radio/radio1...

More strong results for tirzepatide - in participants with obesity and prediabetes tirzepatide TX led to substantial and sustained weight reduction and decreased risk of progression to type 2 diabetes nej.md/48VdDZp

Really looking forward to this interactive public event on all things Ozempic & GLP-1 for Ireland's #ScienceWeek @maynoothuni.bsky.social & online! Myself & Prof Donal O'Shea will discuss the scientific & clinical evidence hopefully busting some myths www.maynoothuniversity.ie/daro/events/...

New TEDx talk from our clinical lead Prof Donal O'Shea on Understanding Obesity - youtu.be/YzP3umk8TWA?...

Can people send/suggest starter packs to follow - our group is interested in the Immunology & immunetabolism of obesity, especially NK & MAIT cells and the links to metabolic disease & cancer!!

Authors project that with expanded access to weight loss drugs like GLP-1s, over 42,000 deaths could be averted annually, including more than 11,000 deaths among people with type 2 diabetes! @PNASNews www.pnas.org/doi/10.1073/...

Delighted for continued support from Health Research Board Ireland for our Obesity Immunology Research work - we are investigating the impact of low iron on #MAITcells #NKcells and #CD8+Tcells

Delighted to introduce DR Andrea Woodcock who passed her PhD viva today!!!

Great trip to Montpellier for French Innate T cell meeting! Happy to share our latest #MAITcell metabolism work & catch up with friends from Sweden & France

Excited to be in Montpellier for the French Innate T cell club - looking forward to sharing our work on MAIT cell metabolism & hearing all things MAITs, Gamma Delta & iNKT

NEW PRE-PRINT 🚨 from @eimearrryan in the lab showing #MAITcells need to pump iron 💪🏼 We show CD71-iron axis is important for mitochondrial function & effector functions like cytokine responses & proliferation dx.doi.org/10.21203/rs....

Snapshot of what our research group does! We are interested in the impact of obesity on the immune system & how dysregulations are linked to increased risk for type 2 diabetes, cancer and viral infection. Also interested in what fuels MAIT cells!