📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT! 👇👇👇 jobs.rutgers.edu/postings/260...

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function ->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social www.nature.com/articles/s41...

Targeting the mitochondrial protein ABHD11 in T-cells may help reduce inflammation and delay autoimmune disease progression by regulating immune cell metabolism. doi.org/g983xc

Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts. www.nature.com/articles/s41...

T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org www.jci.org/articles/vie...

Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸 Please give it a read! www.jci.org/articles/vie...

We hiring! Please share this post with your talented ECRs We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome Based at @lmcb-ucl.bsky.social at University College London Apply here: www.jobs.ac.uk/job/DPD418/r...

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine. www.sciencedirect.com/science/arti...

Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti... Congratulations to Thomas MacVicar & team!

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function. onlinelibrary.wiley.com/doi/10.1111/...

Really pleased to share two review articles the lab has been involved in lately 👇🏻 Thanks for the involvement!

Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort doi.org/10.1016/j.te...

We have a PhD position open for a talented & enthusiastic grad student interested in Neuro-Immune communication in the context of dementia. Come and join myself and @nickjonesimmuno.bsky.social click 👇 or contact me for more info www.swansea.ac.uk/postgraduate...

Preprint: Characterization of the dual roles of senescent-like T cells that arise during healthy and unhealthy ageing www.biorxiv.org/content/10.1... @drsianh.bsky.social

Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org Details 👇 www.sussex.ac.uk/study/fees-f...

Very cool post doc position for someone with immunology and metabolism background. Looking at a ketogenic diet in a RCT setting with Dr Emma Vincent’s group at the University of Bristol. Please reshare! 👇🏻 www.linkedin.com/jobs/view/42...

Great collaboration with @inespinedatorra.bsky.social @georgearobinson.bsky.social @anisurrahman.bsky.social @arrdept-ucldom.bsky.social www.ahajournals.org/doi/10.1161/...

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures www.cell.com/cell/abstrac...

Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social doi.org/10.1016/j.bn...

So excited to see this out please read the paper, article and listen to us on the radio! Big thanks to @uclnews.bsky.social, our superstar postdoc @hlpeks.bsky.social, co-senior author Prof Coziana Ciurtin and collaborators @emmaschambers.bsky.social

Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity https://www.biorxiv.org/content/10.1101/2025.03.19.643996v1

First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated: www.biorxiv.org/content/10.1...

To all my #BlueSky friends...does anyone have Xbp1 conditional knockout mice alive in their labs? Thanks!

We have big news! 📣 Children’s Cancer and Leukaemia Group (CCLG) and Teenagers and Young Adults with Cancer (TYAC) have merged their memberships to form a new professional association. Introducing CCLG: The Children & Young People’s Cancer Association! www.cclg.org.uk #CCLG #CYPCancer

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Exciting paper from the Cantrell lab out in @natimmunol.bsky.social about the role of autophagy in CD8 T cells exploring the role of amino acid availability. Lots of very cool proteomics data quantifying which proteins are degraded under what conditions. @lindavsinclair.bsky.social

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease doi.org/10.1101/2025...

Okey dokey here goes! First real post - please reshare if appropriate 🙏 🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔 We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

LPS stimulates dynamic changes in B cell metabolism to promote proliferation https://www.biorxiv.org/content/10.1101/2024.12.16.628649v1

Our #leukemia starter pack keeps growing! Drop a message if you want to be included! go.bsky.app/EY3k2bE

Thrilled to share our latest work on how the non-essential amino acid #asparagine metabolically regulates germinal centers. Huge thanks to my PhD supervisor @ajclarke.bsky.social, colleagues, and collaborators at the @ndorms.bsky.social @ox.ac.uk and @crick.ac.uk www.science.org/doi/10.1126/...

If you’re interested in immune cell metabolism I’m recruiting for a PhD student. Deadline: 17th Jan. Start date: Sept 2025. Informal discussion always welcome. www.findaphd.com/phds/project...

“Climate change is happening fast, especially in the polar regions,” said Gilbert. “The Arctic is warming four times faster than the rest of the planet, threatening important ecosystems, infrastructure and livelihoods for people living there.”

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below! go.bsky.app/EY3k2bE

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job. www.nature.com/articles/s41... #SingleCell #Immunometabolism #ImmunoSky Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Check it out!!! Our work delineating why T cells aren't needed for Salmonella colorectal cancer therapy, and how to get them on board is out 😅🧪🦠. @cruk-si.bsky.social Collab with @bendinglab.bsky.social @sarahdimeloe.bsky.social #Immunosky #Microsky #metabolism www.embopress.org/doi/full/10....

Great opportunity to join our wonderful immunology, infection and inflammation community in Birmingham!

Treating lupus by depleting B cells with CAR T cells has been shown successful A breakthrough cancer immunotherapy is now taking aim at autoimmune disease | Science | AAAS www.science.org/content/arti...

Congrats Jian Xu, Min Ni, Mitch Weiss and colleagues on this new paper on the importance of glutamine metabolism in erythropoiesis. Such a delight to work with this team. -RJD www.science.org/doi/10.1126/...

Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism? Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...