We present the first subset-specific proteomic signature of electrophysiologically-defined, pain-sensing neurons. One step closer to uniting function with molecules- one neuron at a time. Thanks to all who have contributed, especially @coscialab.bsky.social @garyrlewin.bsky.social #neuroscience

Lovely talk from Samanta Mariani about embryonic #macrophages in hematopoiesis, in health and in malignancy #EMDS2025

Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025

Open call for Free-Floating Max Planck Research Groups! Early-career researchers (≤7 yrs post-PhD) can apply for a fully funded 6-yr group at a Max Planck Institute of their choice (incl. at our institute!) Learn more and apply at: www.fkf.mpg.de/8832208/2025...

I am advertising for a #postdoc for a 3 year BBSRC-funded project exploring the role of macrophages in salivary gland development. The successful candidate will be based at @edinuni-irr.bsky.social at @uni-of-edinburgh.bsky.social. Closing date: 9th Oct. elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Contrasting cell count and biomass distributions by cell type: ◼️ Human cell size and count are nearly inversely related. More quantitatively, ... 🧵

Asking here for others, does anyone have the same issue in USA?, please share to know if that is the case, just to know how many are in the same case. @nesvilab.bsky.social I will give priority to this. For you the entire database in block, even searching?

This week, our amazing team have been meeting people at British Mass Spectrometry Society's annual meeting in Edinburgh - and everyone was a winner with the Drop Disk Game! #MALDI #GCMS #LCMS #massspectrometry #massspec 🧪 @bmss-official.bsky.social

Please note that we will be closing our X account and focusing instead on our new Shimadzu UK Bluesky account. You can find us at: bsky.app/profile/shim... Our first 25 UK Bluesky followers will get a free sciencey bag or mug! Come over and say hi 👋🧪

Exciting to have @erinbakerims.bsky.social open day 2 of BMSS getting us to think about chemical exposure #BMSS2025

hows the rail network in the UK? any good? Well we are stuck in York because a farmer is chasing his cattle which are roaming the train lines further north, and he's unable to capture them. So at least its not boring

@nabalabuic.bsky.social opening up the Uncovering the Matrisome BSMB conference at Surrey.

When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.

It is an honor to inform you that our manuscript with low resolution FAIMS is now online www.biorxiv.org/content/10.1...

CSHL’s John Inglis & Richard Sever have received @royalsociety.org’s 2025 Research Culture Award. www.cshl.edu/inglis-and-s...

As it's the wrap up European Symposium on Single Cell Proteomics we got to see how much it's grown with participants from Brazil and China! #ESCP2025

Mikaela now tells us about the scverse community intrageted ecosystem for single cell with established templates and data structures #ESCP2025

Start of day 2 of the European Symposium on Single Cell Proteomics with @ryankellybyu.bsky.social telling us about high throughput proteomics towards a $10 proteome #ESCP2025

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social. www.science.org/doi/10.1126/... 🧵

Alexander Ivanov talking about increases in sensitivity and signal to noise when changing to ultra low flor rates for single cell proteomics. #ESCP2025

News in Proteomics Research blog post | News in Proteomics Research blog post | Deconvoluting proteomics homogenates with single cell type insights?? proteomicsnews.blogs... --- #proteomics #prot-other

The last session of the day is opened by Tami Geiger looking at the interactions of the immune cells with the cancer microenvironments using single cell proteomics #ESCP2025

Its exciting to see that its a full house at #ESCP2025 lots of enthusiastic single cell proteomics researchers 🤓

Wilfred Rossol is next talking about proteomic profiling of protein aggregates with a more spatial proteomics approach #ESCP2025

Next up is @pedroaragon.bsky.social talking about single cell and low input proteomics to study perturbation in leukemia #ESCP2025

Up next is @jwoessmann.bsky.social from the @erwinschoof.bsky.social lab showing how to focus on the exciting lower abundance proteins with single cell proteomics #ESCP2025

Daniela Valdes from @coscialab.bsky.social lab presents how smoking disrupts the placental function via macrophage dysregulation using single nuclei analysis and deep visual proteomics #ESCP2025

Cool work from @nanopots.bsky.social doing cell surface profiling of 100-500 immine cells using affinity purification #ESCP2025

Next up is @vadim-demichev.bsky.social telling us how quantitatively accurate is single cell proteomics #ESCP2025

After the DVP symposium now begins the start of the European Symposium on Single Cell Proteomics #ECSP25 A quick intro from @kmechtler.bsky.social and we kick off two days of exciting science starting with SCP of neutrophils in glioblastoma

Students celebrate their IRR internship 🧑‍🔬 For four weeks this summer, IRR hosted local high school students as part of both the Edinburgh BioQuarter’s Summer Interns and @edinburgh-uni.bsky.social’s Career Ready programmes. Read about the experience on IRR stories: edin.ac/4oPP33G

Great from from @erwinschoof.bsky.social and his lab showing the added value of SCP!

Seriously pumped for today! Deep Visual Proteomics masterclass here we come 🤓

Start of the European symposium in single cell proteomics at beautiful Viena with a workshop on spatial proteomics organised by @coscialab.bsky.social

If you measure and interpret RNA levels in single cells, read this: "𝑂𝑢𝑟 𝑟𝑒𝑠𝑢𝑙𝑡𝑠 𝑠𝑢𝑔𝑔𝑒𝑠𝑡 𝑡ℎ𝑎𝑡 𝑖𝑛𝑠𝑡𝑎𝑛𝑡𝑎𝑛𝑒𝑜𝑢𝑠 𝑚𝑅𝑁𝐴 𝑎𝑏𝑢𝑛𝑑𝑎𝑛𝑐𝑒 𝑜𝑓 𝑐𝑎𝑛𝑜𝑛𝑖𝑐𝑎𝑙 𝑚𝑎𝑟𝑘𝑒𝑟𝑠 𝑖𝑠 𝑡𝑒𝑛𝑢𝑜𝑢𝑠𝑙𝑦 𝑙𝑖𝑛𝑘𝑒𝑑 𝑡𝑜 𝑡ℎ𝑒 𝑐ℎ𝑜𝑛𝑑𝑟𝑜𝑔𝑒𝑛𝑖𝑐 𝑝ℎ𝑒𝑛𝑜𝑡𝑦𝑝𝑒 𝑎𝑡 𝑡ℎ𝑒 𝑠𝑖𝑛𝑔𝑙𝑒-𝑐𝑒𝑙𝑙 𝑙𝑒𝑣𝑒𝑙." 1/2

scRNAseq has a correlation with the proteome of like 0.1 but hey, they can predict now even the spatial proteome. All good. All sorted.

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

have to say I am starting to appreciate spam emails from predatory journals. Here is what the last one said of me: "Your work as an esteemed contributor in the scientific field has always been a beacon of excellence." Plus I loved the excuse to post a gif lighting the beacons of Gondor.

Speaker Highlight - Samanta Mariani #Macrophages support #HSC development in health but what happens in the context of leukaemia? Join us at #EMDS2025 to hear from Samanta Mariani from @edinuni-irr.bsky.social to find out more. Register today at www.emds2025.com @efis-immunology.bsky.social

Stay tuned and join this fantastic opportunity from @ypic.bsky.social and get your first experience on writing a grant and the chance to get your own money for your project! 💸🔬

Tools "Here we introduce Interact-omics, a cytometry-based framework to accurately map cellular landscapes and cellular interactions across all immune cell types at ultra-high resolution and scale." www.nature.com/articles/s41...

Just in case there was any doubt, ChatGPT 5.0 still makes up completely random citations that don't exist and should not be used for literature search.

Spectronaut 19 played a big role within our single cell analysis pipeline for neutrophils in GBM. Even with more stringent parameters we could detect > 1,100 and define functional states that are invisible to single cell RNAseq.

Journals and funders are trying to boost the speed and effectiveness of review processes that are under strain go.nature.com/4fLcsiR

My generation had to deal with datasets where Excel had autocorrected gene names to dates. Future generations are going to have to deal with the hallucinations of slopbots.

The last day for registering for the Nordic Conference in Mass Spectrometry and Proteomics 2025 in Odense, Denmark, 1-3rd September 2025, is closing in. Please sign up before Friday! www.nordicmsp2025.com

Super proud that my PhD paper is finally out! doi.org/10.1111/all.... RSV leaves long-lasting marks on the lung, potentially boosting future immune responses but also contributing to allergen sensitisation.

🌟 Got exciting immunology research to share? There’s still time to submit your abstract for BSI Congress! #BSI25 Present your findings to 1,500+ experts, grow your network, and spark new collaborations that can boost your career. Submit by 3 Sept ➡️ https://bit.ly/3UfF6i5

Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social rupress.org/jem/article/...

🚀 Release Day Alert! The brand-new #pmultiqc service is LIVE: www.ebi.ac.uk/pride/servic... 🎉 Instantly generate QC reports for #quantms, #DIANN, #MaxQuant & @pride-ebi.bsky.social datasets. Reviewing @pride-ebi.bsky.social quality data is super easy — all powered by pmultiqc: pmultiqc.quantms.org 🔥