ASBMB Journals (@asbmbjournals.bsky.social)

New in JBC press: "Scientists' data illustrate how the modular nature of these chemokines enables their overlapping but non-redundant functions." Learn more: www.jbc.org/article/... #jbiolchem

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Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28 The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10, and the CCL28-specific receptor, CCR3. To identify determinants of receptor activation, internalization and binding specificity, we conducted structure-function studies focused on the N-termini of these two chemokines. Deletion of two N-terminal residues of CCL27 resulted in a CCR10 antagonist, highlighting the critical roles of these residues in driving receptor pharmacology. https://www.jbc.org/article/S0021-9258(25)02588-8/fulltext#author-abstract