Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

Here is reading for this snowy day: Congrats to Hanna Feinsod on publication of our perspective in Ferroptosis & Oxidative Stress on 3 major unanswered questions in #ferroptosis! www.sciexplor.com/articles/fos...

Congrats, @sharpe-lab.bsky.social, on a really great paper! Pervananadate is such a pervasive reagent in pY signaling studies - this work really made me think more deeply about its use! Also, tyrosine kinases and phosphatases, what’s not to love? I enjoyed writing about it!

Congrats!!

For decades, scientists have designed drugs to slow down or block enzymes, but Tarun Kapoor wondered if tackling some diseases requires the opposite approach. We spoke with Kapoor about why speeding up an enzyme is so difficult, and how his team is cracking this problem. See the full Q&A here:

My awesome colleagues at Barnard Chemistry are look to recruit an Early-Career Faculty fellow in computational chemistry. This is a 2-year residential teaching and research fellowship. Please share broadly! #chemjobs barnard.wd1.myworkdayjobs.com/en-US/Facult...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

Unsure how to gain your first peer review opportunity, or keen to improve your feedback? Catch up on our latest ECR webinar and gain practical tips from Biochemical Society Editors-in-Chief on writing and submitting a high-quality review!🧪 https://ow.ly/5pWZ50XNBJs

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

Which cysteines are hyper-reactive in specific cancer types and tissues? The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2) www.cell.com/cell-chemica... #ChemBio #ChemSky #ChemicalProteomics

2025 sucked. In 2026, we are taking back our science! We are excited to launch our Substack: The Science Fight Club. Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action. open.substack.com/pub/sciencef...

Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾 www.biorxiv.org/content/10.1...

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

As a doctor and scientist working to advance health, science, and economic growth in NY, I’m urging @governor.ny.gov to invest in the Empire Biomedical Research Institute to keep the state competitive, sustain jobs, and grow our life science economy. @gothamist.com reports: tinyurl.com/5fab5k7u

1/ Check out our newest paper where we ask: How fast can we experimentally discover binders from scratch? And we mean scratch: a blinded study. TLDR: 26 days. And the binders work…and led to new cancer biology. We’re coming for you AI…. chemrxiv.org/engage/chemr...

New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1

Excited to share our newest paper in @emboreports.org! We used proximity-labeling proteomics to examine how different disease mutations in SHP2 alter its interactions and localization. This was a huge undertaking led by former graduate student Anne an Vlimmeren. link.springer.com/article/10.1...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

The Gonzalez Lab at Columbia University is seeking a scientific leader! Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes. Apply: apply.interfolio.com/176949

Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches" www.janelia.org/content/lead...

Please join us on Dec 12th for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems". Co-organized by @gibbological.bsky.social Registration is free & we have a fantastic line-up of experts! isbscience.org/events/2025-...

@isbscience.org's Dr. Mary Brunkow gave a "practice talk" for her Nobel Lecture, and it was riveting! Mapping the Foxp3 locus was an arduous task in the late 90s, and this recognition is a fitting tribute. Thrilled for you, Mary! Your humility and grace are a wonderful example for all of us.

You have a problem with identifying hydrophobic proteins in proteomic experiments? So did Hyojung Kim in my lab and the entire protein palmitoylation field. Because - 1/n Enhanced S-Palmitoylated Protein Detection by Mild Nonionic Detergent in Proteomic Workflow | pubs.acs.org/doi/full/10....

First time back in the Bay Area since I left Berkeley 7 years ago. Met some old friends after a long time and had an awesome visit at UCSF. Didn’t realize I missed this place!

Check out our newest work! This is a story on how to get selectivity in binders - both isoform and site selectivity. Read the paper or enjoy this brief Skytorial of what we did! www.biorxiv.org/content/10.1... 1/n

FlAsH-ID: A short peptide tag for live cell photoproximity labeling https://www.biorxiv.org/content/10.1101/2025.10.24.684417v1

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

Our paper entitled, "The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2" is out in its final form at Protein Science. Big congrats to former grad students Anne and Jason, and former undergrad Anya! onlinelibrary.wiley.com/doi/10.1002/...

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1

Congrats, Jeanine! @amacherlab.bsky.social

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Congrats, Eunhee and the whole team. This is really cool!

New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development. Study🗒️: https://go.nature.com/4o9oqWn Episode 🔊: https://bit.ly/3LlRCeo

Please share🔉 We’re #hiring #AI #Engineers @columbiaseas.bsky.social @cancerdynamics.bsky.social 🚀Join us to build foundation models that learn & reason about cancer systems, integrating #LLMs #causalAI and multi-modal #genomics. Shape the next-generation of cancer therapies! tinyurl.com/5n7wp8ck

Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins. This was a big team effort led by @inesforrest.bsky.social and in collaboration with AbbVie.

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale See preprint for: — Ensembles of >12000 full-length human proteins — Analysis of IDRs in >1500 TFs 📜 doi.org/10.1101/2025... 💾 github.com/KULL-Centre/...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

Happy to share that our paper with Harmen Bussemaker’s group entitled “Accurate affinity models for SH2 domains from peptide binding assays and free-energy regression” is out in its final form at Protein Science! onlinelibrary.wiley.com/doi/10.1002/...

Skeetorial on our BRAF preprint! tinyurl.com/asymmBRAF The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)

Our work on developing a fluorescent probe to measure granzyme B activity in anti-tumor immunity is finally out! pubs.acs.org/doi/10.1021/...

Come be my colleague! Tufts Chemistry is hiring a tenure-track Assistant Professor working on materials with energy applications. We have a fantastic, supportive environment for you to start your research career. Send questions to me or @chemysl.bsky.social apply.interfolio.com/175284

New Blog Post: Scholarly Communication Is a Research Problem. This Means You. pracheeac.substack.com/p/scholarly-...

Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: www.biorxiv.org/content/10.1...

We’re hiring!📣 Exciting opportunity at the Irving Institute for Cancer Dynamics and School of Engineering and Applied Science at Columbia: Associate Research Scientist. Lead pooled CRISPR + Perturb-seq screens to close AI-identified knowledge gaps. Apply apply.interfolio.com/172825

First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.

affinity, specificity, and selectivity as well as how targeting loops can allosterically alter protein activity. We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)