affinity, specificity, and selectivity as well as how targeting loops can allosterically alter protein activity. We are looking to hire a postdoc to support this work, particularly allosteric mechanisms of molecular glue formation. If you are interested, check out our ad: lnkd.in/g-kyiTST (1/2)

Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously.

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path. rdcu.be/eDzPk

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out: eeik.fa.us2.oraclecloud.com/hcmUI/Candid... Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Open faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social‬! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr... 1/n

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began go.nature.com/3JyRV4S

Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs

Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience. I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾

Congrats to the whole team!

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Really awesome stuff! Congrats to the whole team!!

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social pubs.acs.org/doi/10.1021/...

I swear if we reach 1000 followers on here before #ACSFall2025 I'll eat an entire banana 🍌

Congrats to the whole team. This looks awesome. Excited to dig into it!

On Friday, my phone lit up with urgent texts. First: gunshots, lockdown. Then the photos—bullet holes punched through windows, shell casings scattered across the floor, videos echoing with “pop pop pop.” The CDC campus was under attack. Dozens of my friends and colleagues were inside.

The 2026 Chemistry Faculty Jobs List has 65 tenure-track positions and 5 teaching-only positions: docs.google.com/spreadsheets... #chemsky #chemjobs

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Had a great lab retreat today in Central Park, with team-building games, great conversations, and lots of laughs, followed by delicious food/drinks. Gearing up for my State of the Lab address tmrw, where I’ll recap our past year and discuss what’s on the horizon! So lucky to have this awesome group!

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Congrats to PhD #5 from our lab, Dr. Anne van Vlimmeren, who successfully defended her dissertation yesterday!!! Check out some of Anne's thesis work on the diverse structural/functional consequences of SHP2 mutations: PMIDs 39012820, 40661614, 40631144, 40631229.

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Today marks the 5-year anniversary of congressman John Lewis’ death. He wrote an essay to be published at the time of his death. “When you see something that is not right, you must say something. You must do something. Democracy is not a state. It is an act…” It’s worth a read 👇 Goodnight 💚

Our lab website is live tamirlab.org 😁

The story behind the most recognisable ChemScrapes meme. #chemsky

Congratulations to Dr. Ziyuan (Jason) Jiang, the 4th PhD from our lab! He gave a stellar thesis defense presentation on SHP2 deep mutational scanning, structure, and dynamics. We even managed to squeeze in a new lab photo in the midst of all of the excitement and celebrations!

I am beyond excited and honored to receive a BWF CASI! This amazing program will support my transition from postdoc to faculty as I continue to develop new modeling frameworks for elucidating and programming cellular behaviors.

Happy 11th birthday to @andolab.bsky.social ! 🎂 🥳 Also happy to share that I'm a full prof as of July 1 -- thanks to my awesome group, past and present. We're now looking to grow the team! Looking for someone with amazing protein skills and postdocs excited about evolutionary questions!

We're ending the week on a high note, with one more preprint, led by senior grad students Anne and Jason, with contributions from undergrad Anya, and our long-time collaborator Deepti Karandur!

Check out our latest preprint, from Anne van Vlimmeren in my group and Ross Giglio in @jlmcfalinefigueroa.bsky.social's lab. We used single-cell transcriptomics, biochemistry, and structural analysis, to reveal how mechanistically distinct SHP2 disease mutations yield different cellular states.

New paper online at ACS Bio & Med Chem Au with @taabaman.bsky.social! New peptide probes and inhibitors for caspase 8 pubs.acs.org/doi/10.1021/...

What the fuck NY?! Donate $10 to Skype a Scientist so we don’t lose to fucking FLORIDA.

Fro the last few years, as part of a final assignment in my senior biophysical chem class I ask students to share a class-related memes, with ones they make themselves highly encouraged! For everyone's enjoyment, here are some of my favorites! #chemistry #biochemistry #sigfigs #units 🧪

And of course, we could not have done this without NIH funding that has been critical for supporting my students’ training and my career, and for giving us the resources to shed light on some aspects of the molecular basis of human diseases.

Excited to see this paper out in its final form, and huge congrats to first author Ziyuan (Jason) Jiang just a week before his thesis defense. This work has become an invaluable resource in our lab for SHP2 projects, and we hope it resonates with the whole field. www.nature.com/articles/s41...

Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!

It’s been a weird, unproductive week at the lab and I’m feeling a little down. So here are 10 cool facts about vision:

The findings at the recent trial and today's Columbia chaos is pushing me to the edge. I just sent the following email...

Help us document the impact of NIH grant terminations! If you had a grant terminated, please check your email for a VERY BRIEF survey. If you did not lose a grant but want to help, please share widely with academic colleagues.

Over 60 NIH staff are blowing the whistle on Trump’s assault on biomedical research — calling it unethical, illegal, and dangerous. Grants canceled. Trials halted. Science censored. This is a direct threat to public health. www.standupforscience.net/bethesda-dec...

Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸

More complete analysis of NIH outlays (or lack thereof) from grant-watch.us grant-watch.us/posts/trends...

Biochemist Nick Ide to West Jordan, Utah: “I’m deeply worried about the future of American STEM competitiveness. Pursuing a career in STEM is always going to be well-respected but so many people right now are looking for positions outside of the country. It's sad." 🧪🏠 @nickide.bsky.social

Congratulations to Professor Tom Muir of Princeton University on receiving the 2025 Bristol Myers Squibb Award in Enzyme Chemistry and Chemical Biology from the ACS Division of Biochemistry and Chemical Biology! The BIOL Division will host a symposium in his honor at #ACSSpring2026.

Extra! Extra! Read all about it!Our study from the White Lab is online today! Thank you to all that made the story & my postdoc time phenomenal Forest White Roger Davis Jess Spinelli @mvhlab.bsky.social @alextoker.bsky.social @mitkochinstitute.bsky.social www.sciencedirect.com/science/arti...

I wrote something to say that scientists cannot afford to be 'apolitical' Scientists actually have the skills and the duty to join in the fight against authoritarianism www.theguardian.com/commentisfre...

Focusing on happy news… I’m so proud of our undergrad researcher Zijing for her graduation from Barnard this week. Zijing did superb work on kinase and SH2 sequence recognition while in the lab (papers coming in the next year). I’m also happy to announce the awesome award I just received (from her).

We still have an open postbac position in the intramural program of the NIH for starting sometime this summer. Shares, reposts much appreciated-