Dr. Meghan Koch from @fredhutch.org has discovered a biological mechanism sprung in the first week of life that trains a mouse pup’s #ImmuneSystem to tolerate harmless gut bugs and new foods. ⚗️ Abstract: https://bit.ly/4nt6qGh 📰 Press release: https://bit.ly/46N7vBY

Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week! Couldn’t have happened to a nicer person: isbscience.org/news/press-r... @isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social

This morning, @isbscience.org's Dr. Mary Brunkow was awarded the 2025 Nobel Prize in Physiology or Medicine! Dr. Brunkow shares the award with Fred Ramsdell and Shimon Sakaguchi. Read the press release here: www.nobelprize.org/.../medicine.... What a tremendous honor! Congratulations!

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Many congratulations, Mary Brunkow! Couldn’t be happier for you and @isbscience.org ! ♥️ www.nobelprize.org

It was an honor to highlight this fantastic work by Cheng and Venkatesh et al of the Gordon lab. Many thanks to them, and to Francis Chandra for doing all the heavy lifting on this Spotlight! @cp-cellchembiol.bsky.social

Happy to kick off 2025 with this new review on gut microbiota-neuroepithelial signaling by the very talented Taka Ohara!

Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org doi.org/10.1016/j.ch...

Happy to see this paper, led by former grad student Cassie Chartier, out in its final form at Protein Science! We characterized the interaction between PTP1B and the ubiquitous signaling adaptor Grb2 and identified new PTP1B interactors along the way! onlinelibrary.wiley.com/doi/full/10....

Excited to share a new preprint from our lab, joint with the Bussemaker group, where we combined peptide display and selection with biophysically interpretable machine learning to build affinity models for SH2-phosphopeptide recognition. www.biorxiv.org/content/10.1...

Fantastic work! Congrats @nandangokhale.bsky.social, @ramlabuw.bsky.social and team.

Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff! www.nature.com/articles/s41...

Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare! isbscience.org/news/2024/12...

Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe? Amazing work by Julia Gross and collaboration with Iain Fraser! rdcu.be/d1Phk

ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more: isbscience.org/news/2024/11...

This job has so many ups and downs, but one constant that I’m always thankful for is this creative, hard-working, supportive group (they support me, too!!). I’m also thankful for all the awesome ideas and cool data they generate, which keep us all motivated and stimulated and make this so much fun!

Innovative and inspiring biochemistry from Joe Luna @virologistjoe.bsky.social and colleagues that combines CLIP with proximity labeling to reveal RNA:RBP interactions at subcellular resolution! Congratulations for your first paper as a corresponding author ♥️ rnajournal.cshlp.org/content/30/7...

First post on a lovely story from the lab that shows that Faecalibacterium prausnitzii can package its own genome in bite-size segments in phage-like capsids www.biorxiv.org/content/10.1...

Delighted to share work by Kristie Yu, Celine Son, & co showing that selective fructan metabolism by the gut microbiome can contribute to host associative learning of dietary preference, even when it comes to choosing between diets with the same perceptual salience (and macronutrient composition!)

Some really beautiful biochemistry here. Seeing one dalton shifts to pinpoint how an enzyme from a nutrition-therapy-linked microbe works must be gratifying. Basic biochemistry lighting the way on an important problem. Congrats to my buddy Sid (@flash-point.bsky.social‬) and team on this one!

Co-varying coffee-derived metabolites are associated with L. asaccharolyticus! A cool paper by multiple luminaries in the field that set the stage for causal roles. Accompanied by a commanding News & Views piece by Nate [email protected] and colleagues. www.nature.com/articles/s41...

Mulling over a preprint from @nshahlab.bsky.social and colleagues on deep mutational scanning to yield insights into activity and regulation of the tyrosine phosphatase SHP2, as well as uncharacterized clinical variants. Beautiful work! ❤️ www.biorxiv.org/content/10.1...

We are elated for @isbsci.bsky.social Assistant Professor Dr. Sid Venkatesh, co-first author of a paper in Science. isbscience.org/news/2024/11...

I read this work from @ramlabuw.bsky.social and colleagues about splicing of IFN-gamma transcripts being regulated by IL-2! Interesting and neat idea... www.embopress.org/doi/full/10....

Intriguing paper linking bacterial strains (L. reuteri) and corticosterone release in a circadian rhythm-dependent manner from @jfcryan.bsky.social and colleagues. Kudos for the Zeitgeber time experiments! On to L. reuteri-encoded molecules that mediate these effects... www.cell.com/cell-metabol...

Heart warming stuff from UW’s Microbial Interactions and Microbiome Center (mim_c) helmed by Drs. Joseph Mougous and Kyle Asfahl! Article by Neuroscience PhD candidate Monica Tschang. mimcuw.org/newsevents/a...

Last month, my co-first author, Dr. Jiye Cheng and I reported the identification of a gut microbial enzyme that impacts satiety-related signaling pathways in undernourished children treated with a microbiota-directed complementary food. www.science.org/doi/10.1126/...

Happy to join this community! Excited to learn and discuss science with y'all.