Anna Kuchina
@annabiosys.bsky.social
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Assistant Professor at
@isbscience.org
studying single-cell lifestyles of bacteria.
pinned post!
How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch).
www.biorxiv.org/content/10.1...
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Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
https://www.biorxiv.org/content/10.1101/2025.01.13.632860v1
9 months ago
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Dmitry explains how surprisingly universal functional patterns emerge once you look closer into a bacterial community.
@isbscience.org
add a skeleton here at some point
about 17 hours ago
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What an astonishing achievement, congratulations Mary!
@isbscience.org
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about 17 hours ago
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Anna Kuchina
Alice Kane
5 months ago
Check out our latest preprint on the development of clocks to predict PhenoAge in mice!
www.biorxiv.org/content/10.1...
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Multiomic clocks to predict phenotypic age in mice
Biological age refers to a person's overall health in aging, as distinct from their chronological age. Diverse measures of biological age, referred to as clocks, have been developed in recent years an...
https://www.biorxiv.org/content/10.1101/2025.04.30.651114v1
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Anna Kuchina
Vivek Mutalik
7 months ago
Huge work from
@benadler.bsky.social
et al
@cresslab.bsky.social
; Glad to be part of this super cool work.
add a skeleton here at some point
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Anna Kuchina
Sean Gibbons 🦠💩
8 months ago
I sat down with
@isbscience.org
president Jim Heath, to chat about our work, which you can watch here:
youtu.be/ZwMDqp5n1S4?...
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Scientists Develop First Stool-Based Test for Tracking Diet and Disease Risk
YouTube video by Institute for Systems Biology
https://youtu.be/ZwMDqp5n1S4?si=3dL53WK6OOf4SPbB
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Estimation of diet from the metagenomics data is now possible! Curious to see how this can be applied for reanalyzing existing datasets to link the diet information with the data
add a skeleton here at some point
8 months ago
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Anna Kuchina
Sean Gibbons 🦠💩
8 months ago
What a stupid, petty move (rising to the top of the many many stupid, petty moves by this administration so far). Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!
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Katie Mack
8 months ago
I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.
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White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
https://www.washingtonpost.com/business/2025/01/27/white-house-pauses-federal-grants/
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How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch).
www.biorxiv.org/content/10.1...
loading . . .
Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...
https://www.biorxiv.org/content/10.1101/2025.01.13.632860v1
9 months ago
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reposted by
Anna Kuchina
ISB
10 months ago
ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more:
isbscience.org/news/2024/11...
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ISB-Developed MetaboCore Offers Precision Cancer Care Faster Than Ever
ISB's MetaboCore is a diagnostic tool that can help physicians quickly select the most effective systemic therapy for each cancer patient.
https://isbscience.org/news/2024/11/27/isb-developed-metabocore-offers-precision-cancer-care-faster-than-ever/
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Anna Kuchina
Sid Venkatesh
10 months ago
Warm congratulations to my
@isbscience.org
colleagues
@gibbological.bsky.social
, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare!
isbscience.org/news/2024/12...
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ISB Named Winner of 2024-2025 Amazon Web Services IMAGINE Grant for Nonprofits
ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.
https://isbscience.org/news/2024/12/03/isb-named-winner-of-2024-2025-amazon-web-services-imagine-grant-for-nonprofits/
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Anna Kuchina
Sid Venkatesh
10 months ago
Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff!
www.nature.com/articles/s41...
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Diverse viral cas genes antagonize CRISPR immunity - Nature
We demonstrate that phages have co-opted cas genes from CRISPR defence systems, which subsequently evolved anti-defence functions.
https://www.nature.com/articles/s41586-024-07923-x
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Anna Kuchina
Sean Gibbons 🦠💩
9 months ago
Great highlight by Chandra and
@pipethero.bsky.social
on recently published work by my colleague
@flash-point.bsky.social
(from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite.
@isbscience.org
doi.org/10.1016/j.ch...
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Redirecting
https://doi.org/10.1016/j.chembiol.2024.11.007
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