Pooled CRISPR screens with transcriptomics readout arrived for bacteria. We introduce mapSPLiT, an approach to profiling transcriptional responses to CRISPR perturbations at scale. Collaborative work with Carothers, Zalatan, and Seelig groups at UW&@isbscience.org www.biorxiv.org/content/10.6... 1/4

Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week! Couldn’t have happened to a nicer person: isbscience.org/news/press-r... @isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social

Dmitry explains how surprisingly universal functional patterns emerge once you look closer into a bacterial community. @isbscience.org

What an astonishing achievement, congratulations Mary! @isbscience.org

Check out our latest preprint on the development of clocks to predict PhenoAge in mice! www.biorxiv.org/content/10.1...

Huge work from @benadler.bsky.social et al @cresslab.bsky.social; Glad to be part of this super cool work.

I sat down with @isbscience.org president Jim Heath, to chat about our work, which you can watch here: youtu.be/ZwMDqp5n1S4?...

Estimation of diet from the metagenomics data is now possible! Curious to see how this can be applied for reanalyzing existing datasets to link the diet information with the data

What a stupid, petty move (rising to the top of the many many stupid, petty moves by this administration so far). Dispersing free HIV medication is one of the greatest unequivocally 'good' things the US does for the world. This program has saved 25 million lives. Why the fuck would you cut it?!

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...

ISB Associate Professor Dr. Wei Wei has developed a promising new companion diagnostic tool called MetaboCore to help physicians quickly select the most effective systemic therapy for each cancer patient. Learn more: isbscience.org/news/2024/11...

Warm congratulations to my @isbscience.org colleagues @gibbological.bsky.social, Andrew Magis, and team for winning a 2024 Amazon Web Services IMAGINE grant for developing "My Digital Gut", an online platform for personalized, predictive, and preventive healthcare! isbscience.org/news/2024/12...

Finally caught up with some beautiful work from Alex Meeske in Nature! His lab has identified proteins in Listeria that either substitute for Cas in Cascade complexes (anti-type I-B CRISPR immunity) or degrade crRNA (anti-type VI-A CRISPR immunity). Inspiring stuff! www.nature.com/articles/s41...

Great highlight by Chandra and @pipethero.bsky.social on recently published work by my colleague @flash-point.bsky.social (from his postdoc work) on endocannabanoids produced by specific members of the gut microbiota that likely impact host satiety/appetite. @isbscience.org doi.org/10.1016/j.ch...