Dr. Mary Brunkow is a 2025 Nobel laureate. In today’s @isbscience.org press conference, she shares the FOXP3 story, from a puzzling mouse to a discovery that reshaped immunology. 🎥 Watch the full video: youtu.be/vg61fbycGEk

Rubbing shoulders with a @nobelprize.bsky.social laureate! 🤩What a week! Couldn’t have happened to a nicer person: isbscience.org/news/press-r... @isbscience.org @naehasubramanian.bsky.social @flash-point.bsky.social @annabiosys.bsky.social

Many congratulations, Mary Brunkow! Couldn’t be happier for you and @isbscience.org ! ♥️ www.nobelprize.org

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Pika in the wilderness of Mt. Baker. #pika #pnw #photography #wildlife

What are you up to? #birds #barredowl #pnw #Seattle #photography

Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."

Please read this wonderful article about my fabulous partner in life, Dr Jennifer Quinn and her work at the Seattle Math Museum! Spread the mathematical joy! @jennifer.j.quinn www.geekwire.com/2025/seattle...

Postdoc position (please re-post) A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. If interested in more information, please contact Hank Seifert [email protected] #MicroSky

We're hiring! Our lab @ISB is looking for a full-time Research Associate to manage our mouse colony 🐭, run experiments in a Type 1 diabetes model, and help keep the lab running smoothly. Ideal for someone aiming for grad school or further scientific training. isbscience.bamboohr.com/careers/56

My heart. Members of the US Public Health Service (the uniformed service branch no one has ever heard of, who serve at the CDC and elsewhere in the US), massed within the CDC property, saluting their departing uniformed leaders who were escorted out by security today after resigning on principle.

CDC staff held a “clap-out” on Thursday to honor three of the agency’s high-ranking officials, who resigned in protest after President Trump fired the director, Susan Monarez. nyti.ms/4oSxakJ

Abbe Lowell and I represent CDC Director #SusanMonarez. Contrary to govt statements, Dr. Monarez has neither resigned nor yet been fired. She will not resign. We have issued the following statement:

“Putin would eat you for lunch.” Today, exactly that happened.

Let's please keep the remaining staff at NIH, NSF, etc in our thoughts even as you lose sleep over your own lab and scientific career. They are enduring pure chaos to try to hold the fort. See snapshot from wapo.st/4feKKuu (gift 🔗) saying they are "barely holding it together"

Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!

Now up, led by Ashton Omdahl! Our method GLEANR finds shared genetic factors across lots of GWAS, and handles spurious correlation driven by cohort overlap. Neat examples of factors driving related traits with enrichment in different cell types / developmental stages.

The NIH was healthiest when pay lines were in the 20th percentile range. We are headed into an environment where pay lines are in the 5% range. In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one. This is going to destroy science.

When we held our rally after the roundtable on Monday to support the #NIH science, we invited Jay Bhattacharya to join us. He declined saying he was disappointed we “made it political.” But supporting NIH isn’t partisan! www.politico.com/news/2025/07...

Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...

Happy Birthday, Rosalind Franklin. She captured an X-ray diffraction image of DNA and stated that a helical structure was probable. Watson and Crick then created a detailed model based on her results. They initially received credit for the discovery and were awarded the Nobel Prize after her death.🧪

Another Bhattacharya email today 1/4

Abughazaleh: I am from one of those families. I do not want Israeli children to live in fear. And I don't want gazan children to starve to death. And there is no enemy of either state that could want me to wish that or excuse the starvation of children. It is that simple.

Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine: jobs.unige.ch/www/wd_porta...

Each Friday, I write a summary of what happened this week in science 🧪& higher ed: - EPA shutting down office of research - NIH selecting politically-preferred reviewers - ICE surveillance tech - unsnarling research funding news This was Week 26, a marathon. buttondown.com/liminalcreat...

Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria go.nature.com/44GsxT2

Harborview Medical Center in Seattle provides high-level trauma care for AK, ID, WY, & MT. Republican health care cuts are putting a major strain on them and every hospital.   A rural hospital fund doesn't help Harborview or the people in Republican states who count on them.

Excited to announce that our collaboration with @briandaniels.bsky.social has been published today! So happy for everyone involved, but especially me and Marissa 😆. Check it out if you're interested in #neuroinflammation and the #BBB www.science.org/doi/10.1126/...

New Episode! Talking about Lyme Disease and discussing it in the greater context of “Contested Diseases” With @kavehtaherian.bsky.social & Dr. Andrew Nowalk iTunes: tinyurl.com/afdya6v6 Spotify: tinyurl.com/2kfmsr4m

❗How can a cancer exploit its environment and still resist treatment? ✅The answer: co-existing malignant subclones. Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵 doi.org/10.1158/2159...

This is not about the merits of Iran’s nuclear program. No president has the authority to bomb another country that does not pose an imminent threat to the US without the approval of Congress. This is an unambiguous impeachable offense.

Major update to #SCIMaP visualization of impacts of cuts to federally supported health research. Map now includes information on future economic losses (impact of proposed reduction of NIH IDC to 15%) and current economic losses (impact of terminated NIH grants). scienceimpacts.org

This is the guy who's deciding which of our science programs to cut

New @isbscience.org research shows how microbial teamwork behind denitrification can collapse in polluted environments, threatening ecosystem balance and resilience. isbscience.org/news/environ...

If we're discussing "hostility to the U.S.," let's start with Donald Trump's description of certain cities Atlanta: "falling apart" Baltimore: "a filthy place" Chicago: "totally out of control" Philadelphia: "struggling" San Francisco: "disgusting" Moscow, Russia: "a great city," "an amazing place"

Yes, if we're punishing nations for their actions by sanctioning their citizens, then conferences should dis-invite Americans. Honestly, I'm not sure where I stand. I'd welcome sanctions on myself, if it could put some pressure on the criminal regime running my country. Slippery slope, though...

The findings at the recent trial and today's Columbia chaos is pushing me to the edge. I just sent the following email...

Love the 9 yo w the Trump is Sus sign. 10 yo made me put ‘Kings are Cringe’ on our sign and explained cringe meant like sus and all the kids would appreciate it.

🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏🤏 *squinting* We had more people at the Lincoln Memorial for our Stand Up for Science rally on March 7th! #StandUpforScience #FailedBirthdayParade

The day started with tragedy with political violence in MN and instead of being scared, neighbors SHOWED UP to stand together at No Kings Twin Cities. We packed the Capitol Mall all the way to the Cathedral. Estimate 80,000+ right now. So proud of our state. #nokings #indivisible

What a turnout! I’d hazard to guess 10k or more in Seattle for #NoKings

Cool paper from the Hyde lab! RNA structure affects VEEV replication in macrophages. europepmc.org/article/MED/...

2,169 events across 20 countries. Millions of peope are standing up tomorrow to say with one voice: No Kings!

What a fantastic day spent UW Immunology! Lot of fun at my seminar, & amazing discussions about #interferons, host derived signals, #inflammasome, inflammatory diseases, & the many different ways cells can die & their consequences! Thanks @ramlabuw.bsky.social @drewoberst.bsky.social for hosting me!

mRNAs encoding adjuvant proteins boost immunity. A fantastic study from Hunter et al shows the value of IL12. Study validates original work on this concept, ref below. Kudos to the authors on this exciting discovery! www.science.org/doi/10.1126/...

Very smart, high ROI initiative from the Spencer Foundation. Providing bridge funding for canceled NSF grants: 1) directs funds to projects already screened by a top-noch review process. 2) avoids imposing proposal prep costs on researchers. 3) ameliorates the disruption from GOP sabotage.

Bloomberg: 'The Silent Virus Behind Mono Is Now a Prime Suspect in Major Diseases' 'Epstein-Barr virus, which causes glandular fever, was once dismissed as a rite of passage. Scientists now link it to cancer and multiple sclerosis' www.bloomberg.com/news/article...