😮Maybe a huge finding... norepinephrine pulses during deep sleep are a key factor for clearance of "waste" in the brain, and not sleep duration or amount of NREM sleep per se. 😴💤 TL;DR Ambien (zolpidem) blocks this process, so probably not great for you www.cell.com/cell/abstrac...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

THIS... every damn time. 👇

Challah bread french toast with orange and brandy!

In case anyone needs a reminder...

Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.

French dip and Mac N Cheese - yes please! #homemade #baguettes

Baguette time! The essential ingredient to an amazing French Beef Dip… #oMGTheSmellIsAmazing

You probably heard about the Government of Canada’s $1.7 billion Canada Global Impact+ Research Talent Initiative... well apparently Dalhousie is recruiting 30 Tenure-track positions. See (and search for Impact+) for more jobs: link.webtrackz.com/hEtS?recipie...

Sooo… PML nuclear bodies (NBs) are conspicuously missing in the big 4D nucleome project overview. Were the chromatin interactions at their periphery too dynamic to capture reliably or just ignored? PML NBs exist in most vertebrates (except boney fish) but are missing in fungi and invertebrates.

"By curating a diverse dataset of 200 papers and evaluating 15 domain-specific jailbreak strategies, we demonstrated that "Lazy Reviewers" relying on Language Models can be easily manipulated into accepting rejected papers" arxiv.org/html/2512.10...

File under you can't make this 💩up... #BCPolitics #ThisIsWild pentictonwesternnews.com/2025/12/14/o...

Evolutionary biology for the win (again)! E. Coli derived LplA rescues mammalian Lipt1 (lipoyltransferase) deficiency in Lipt1 KO mice 😱 www.science.org/doi/full/10....

Good to know!

How do people feel about Nanodrop for RNA and DNA quantification? Less flaky now? Alternatives? Thoughts/comments?

Billy Strings on NPR's Tiny Desk Concerts! This makes me so happy... check it out, crank it up and enjoy 👇https://youtu.be/WgqaxMOKfnI?si=mqSHb1bMh1_p2vai

I really want to know who the Libs are consulting to come up with these ideas. Because no person who knows anything about the current research and funding ecosystem in 🇨🇦 (or who has historical insight on similar past schemes) would come up w this as a priority policy, let alone a good use of funds.

My first attempt “no-bake” cheese cake!

👀waat!

📣Another great collaboration with Neale Ridgway (Dalhousie University) on the promyelocytic leukemia (PML) protein and lipids. Here we show how induction of inner nuclear membrane (INM) curvature stress leads to PML II patches at the INM. Check it out 👇 www.molbiolcell.org/doi/10.1091/...

Whee 😆 #wildlifephotography #wednesdaymotivation

The liberals are doubled-down on long-gun buy back and then they want to 'equip' 300,000 citizens with ammunition and guns as part of a civilian force. So, take hunting rifles and give them assault rifles? The whiplash from these policy decisions is making my neck hurt. www.cbc.ca/news/politic...

Say what?! The government wants to ban "certain" individual's from FOIPOP requests? WTAF #ThisIsNotWhatTransparencyLooksLike

You know what is ironic? If the Liberals added $1.7B dollars to the base budgets of the Tri-Council, and ear-marked it for open investigator driven research programs over 5 years - CANADA would instantly be a better research ecosystem, attracting new talent. 🙃🤦 www.france24.com/en/live-news...

Worth checking out - might breathe some life into your old wide-field setup. 👇

What he said 👇👇👇👇👇👇👇👇 * 100 agreement

Coming to your social media feeds NOW... multi-cancer early detection (MCED) tests - #PATHFINDER #CancerSeek #CancerGuard #Galleri #DETECTA www.nature.com/articles/d41...

Just three crows…

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Canada announces new immigration measures for foreign-trained doctors - because process was just taking too long! www.ctvnews.ca/canada/artic... @ctvnews-mirror.bsky.social

Kinda important to consider.

It's official - Alberta separating (or any other province) is unconstitutional globalnews.ca/news/1156416...

Cohesin drives chromatin scanning during the RAD51-mediated homology search www.science.org/doi/10.1126/...

If you or your trainees are just getting started with image analysis of cells & are #CellProfiler -curious, here is a fairly thorough walk-through demo I did recently. Loading files, extracting metadata (fun with Regex!), identifying objects, measuring, filtering, QC, exporting: youtu.be/fO5nJdhj_7I

Great summary and context of our recent study on this podcast. Even includes interpretive song. basebybase.castos.com/episodes/53b...

My first attempt at making Black Sourdough - with molasses, coffee and cocoa

Saturday is bake day! #Sourdough

“Elon was here”

Developed initially to target and kill tumors, they are now being engineered to target cells that are contributing to autoimmune diseases, like antibody-producing B cells. #Science 🧪

It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!

And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport. Definitely worth a deep read: www.pnas.org/doi/10.1073/...

In my opinion, once you have > 15 staff and trainees - you are running a business and not a lab and QC drops hard. To do this well you need very well trained research associates who basically do your job for you - and likely better than you could do it. Keeping those people is TOUGH. Ergo QC tanks.

To be fair, I am pretty sure only people in Newfoundland are "codnapped". So, Allan Hawco would be the best bet. #RepublicOfDoyle

“The less time you spend on surviving, the more you can be thriving!” - Aurora