The mitochondria in a cell are weirder than you think. Not just “the powerhouse of the cell,” but more like a shape-shifting, constantly remodeling, mildly unhinged energy blob. #CellBiology

Interesting and provocative thread. IMO (evolving) - genAI is a tool, like a calculator, which can do some neat stuff and can be useful. But it's not anywhere near a replacement for human brains and definitely not a replacement for teaching students how to think critically and do actual research.

Data visualization is a critical step in data analysis. 8 links to bookmark for better data visualization:🧵

Amazingly, reaction times using screens while driving are worse than being drunk or high—no wonder 90 percent of drivers hate using touchscreens in cars. Finally the auto industry is coming to its senses.

2025 was brutal for US transit. Agencies faced budget deficits, flat ridership, and open hostility from the White House. I wrote a series of stories outlining ways to help transit endure. Lesson #1: Whatever you do, don’t cut service. Riders will leave – permanently. Here are a few others 🧵

Make a Bond movie academic: For Your Eyes Only: Two-Factor Authentication in Higher Ed

Make a Bond movie academic Dr. No: the pitfalls and dangers in using medical LLMs

Make a Bond movie academic Skyfall: Analysis of fine particulate matter on precipitation duration and intensity in mid-latitude maritime climates

Make a Bond movie academic Die Another Day: p53 inactivation by viral inhibitors of apoptosis

ICE detain father shopping on Christmas Eve—then steal his family's groceries. Then 3 agents divvy up his paid for food—taking what they want for themselves. "Can I just get the wife's number to call and let her know?" woman asks. "No, guess he should've complied," agent says. Yakima, Washington

In 2020, the Trump administration invited Ahmed to talk about the rise of anti-semitism online. His mission has not changed, but they have. After Musk took over Twitter he unsuccessfully sued Ahmed for documenting the increase in online hate. Now the Trump admin is enabling Musk's censorship.

Anger, L., Schoenit, A., Wodrascka, F., Rossé, C., Mège, R. M., Ladoux, B., & Marcq, P. (2025). Tissue stress measurements with Bayesian Inversion Stress Microscopy. arXiv preprint arXiv:2512.00550. arxiv.org/abs/2512.00550 #EpithelialMechanics

Merry Christmas and Happy New year from Hunter, the feral cat (clipped & snipped) who is fed by my mom and half a dozen neighbors. This is his heated cat house on a nearby porch. #OrangeCat

“Like prime, but with human beings”

Recreating this legendary Peanuts scene. Yeah hoe!

James, J., Winn, L. B., Mottram-Epson, P., & Köster, D. (2025). Paths to stability–actin regulation of adherens junction mechanics. Journal of Cell Science, #EpitheilalMechanicsReview doi.org/10.1242/jcs....

Bwtween Woke Pope and Father Jud, I'm almost tempted to give the Church another chance. (Although I do remain firmly in the Benoit Blanc camp.)

Merry Christmas to all who celebrate. And for everyone - a few minutes of pure joy: youtu.be/UrRZ-kKnBEw?...

Haha, so I asked #ChatGPT for examples of common names or phrases with choriambic meter (DUM da da DUM) and this is what it gave me.

Senescence biomarkers p16 and p21 are often very difficult to detect in human tissues, our assay ICLAP makes a lot easier.

The Free Speech Union, GB News, and Spiked all care passionately about free speech will all be incensed by this and offering their support.

We know that birds can sense magnetic fields for navigation. But how does that work? Do they have little magnets wired up to their brains? The most likely answer is 1000X times weirder than that, and involves quantum spin. Let's talk about 'cryptochromes' & magnetic sensing.🧪

Irma's @irmusjay.bsky.social paper is under the Christmas tree 'in press': Nuclear Myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors doi: doi.org/10.1016/j.jb... including SIM imaging of myosin IV with actin on androgen receptors and RNA-Pol2

Enjoy these human epithelial cell nuclei - especially the bagel with a hole right through the middle! MCF10A cells with labelled with DNA (blue; Hoechst), anti-lamin A/C (green), and F-actin (magenta; phalloidin). 3D z-stack taken with a Zeiss CellDiscoverer7 + LSM 900 Airyscan-2, 20X (NA 0.95).

#NFDI4BIOIMAGEfromAtoZ - T as in TIFF When working with microscopy data, you often need image formats that preserve every detail of your measurements. #TIFF (Tagged Image File Format) is a raster image format particularly suited for high-quality, multidimensional microscopy data.

Malboubi, M., Esteki, M. H., Vaghela, M. B., Korsak, L. I. T., Petrie, R. J., Moeendarbary, E., & Charras, G. (2025). The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients. Elife. doi.org/10.7554/eLif... #EpithelialMechanics

Our recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪 www.nature.com/articles/s44...

Wow, exciting convergence of chem bio technologies in this paper! 🤯

Very good from Dan Rather. He details the timing of the decisions by Weiss and how this actually played out.

Wow, yeah, I just copy-pasted from my phone browser to Notes and the reactions disappeared.

😮

Sounds like they're trying to Bari the story.

"I think refusing is actually the more hopeful, expansive vision of the future than the one that is telling us that the future is already settled and decided. That's my daring idea. Just say no."

Something lovely for the weekend! A 1,800 year-old Roman glass flask shaped like a mouse! Squeak squeak! 🐭❤️ 📷 by me www.metmuseum.org/art/collecti... #Archaeology

I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍

Happy #BatMas everyone! Follow this thread ⬇️ or check out the hashtag to find out about a new bat species everyday, for 25 days! 🦇🌎🧪 #BatSky🧵

As told by the late dancer and choreographer Agnes DeMille.

12/20/25 A Chicago business owner showed up for a green card interview. He was detained and died under #ICE custody.💥 youtube.com/shorts/uae6G...

Receptor tyrosine kinases bind ligands and (often) dimerize. Yet how long, and how does that change their mobility? Using single-molecule FRET in living cells, we found that MET dimers 'socialize' for ~1 second while lowering lateral diffusion and confinement 👉🏻 doi.org/10.1002/smll...

So disgusting that the FBI basically covered for and enabled this con artist and the rich men he procured for.

New video: more examples showing deep learning segmentation failure modes—and how to detect them with Napari. I show how Napari’s layer system compares images, ground truth, and results, and how Appose enables comparison across incompatible DL packages. www.youtube.com/watch?v=c369...

I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a @zeiss-microscopy.bsky.social LSM880 with Airyscan. #FluorescenceFriday #Microscopy

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

The science behind gender-affirming care has been endorsed by every major medical organization. This isn't about science or medicine. It's about the discomfort many non-trans people feel over the *existence* of trans people.

“Randomizing newborns to no hepatitis B vaccine at birth in order to evaluate “overall health effects” of an intervention whose primary benefit is already known is indefensible. When benefit is established, withholding an intervention is no longer neutral experimentation; [it is] premeditated harm”

archive.ph/0k5by (non-paywall link)

Funny how LLM companies are spending millions to discover what students learn in the first year of business school. At least the employees are having lolz.