Directed evolution on compact landing pads yields highly efficient recombinases for large DNA integration academic.oup.com/nar/article/...

AI learns from chromatin data to uncover gene interactions www.nature.com/articles/d41...

Medical breakthroughs in 2025 www.scientificdiscovery.dev/p/medical-br...

"A mathematical model is a logical machine for converting assumptions into conclusions. If the model is correct and we believe its assumptions then we must, as a matter of logic, believe its conclusions. " link.springer.com/article/10.1...

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

An integrated view of the structure and function of the human 4D nucleome www.nature.com/articles/s41...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene | Science www.science.org/doi/10.1126/...

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.cell.com/cell/fulltex...

The evolving landscape of RAS-targeted therapies www.nature.com/articles/s43...

High-fidelity human chromosome transfer and elimination www.science.org/doi/abs/10.1...

Multiscale structure of chromatin condensates explains phase separation and material properties www.science.org/doi/10.1126/...

Cohesin drives chromatin scanning during the RAD51-mediated homology search www.science.org/doi/10.1126/...

"We find that the evidence for in vivo LLPS is often phenomenological and inadequate to discriminate between phase separation and other possible mechanisms. Moreover, the causal relationship and functional consequences of LLPS in vivo are even more elusive" (2019) pubmed.ncbi.nlm.nih.gov/31594803/

Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...

Some of the eggs laid by Iberian harvester ant queens contain males of another species, the builder harvester ant – and these males father all of the workers in the colony.

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years. www.cell.com/cell-reports...

Site-specific DNA insertion into the human genome with engineered recombinases www.nature.com/articles/s41...

Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi) elifesciences.org/articles/106...

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.cell.com/cell/fulltex...

Bacterial tubular networks channel carbohydrates in insect endosymbiosis www.cell.com/cell/fulltex...

Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...

Transcriptional interference gates monogenic odorant receptor expression in ants www.cell.com/current-biol...

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social #CRISPR #Drosophila www.biorxiv.org/content/10.1...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social www.science.org/doi/10.1126/...

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...

Is enhancer-driven gene regulation all wrapped up? www.nature.com/articles/s41...

Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function genesdev.cshlp.org/content/39/1...

What makes genes burst www.cell.com/trends/cell-...

[Review] Configuring the code: Enhancer-Promoter arrangement and transcriptional regulation in @jmolbiol.bsky.social #genesky www.sciencedirect.com/science/arti...

A de novo-originated gene drives rose scent diversification www.cell.com/cell/fulltex...

Driving a protective allele of the mosquito FREP1 gene to combat malaria www.nature.com/articles/s41...

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ www.nature.com/articles/s41...

New online: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics

Range extender mediates long-distance enhancer activity www.nature.com/articles/s41...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu. Explained for non-experts!

🚨Our latest work on selfish centromeres is published @currentbiology.bsky.social 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to our lab manager, Zaak Walton, who led the project🎉 Free link: authors.elsevier.com/a/1lQzN3QW8S...

Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!! www.sciencedirect.com/journal/jour...

Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs www.nature.com/articles/s41...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation www.nature.com/articles/s41...

Mechanisms and timing of programmed DNA elimination in songbirds www.biorxiv.org/content/10.1...

It was a pleasure to write a N&Vs on @danielibrahim.bsky.social's latest paper in @natgenet.nature.com. Enhancers tend to stay put even if their sequence changes beyond recognition. Quoting Il Gattopardo, everything must change so that everything can stay the same: www.nature.com/articles/s41...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...