Bacterial tubular networks channel carbohydrates in insect endosymbiosis www.cell.com/cell/fulltex...

Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...

Transcriptional interference gates monogenic odorant receptor expression in ants www.cell.com/current-biol...

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social #CRISPR #Drosophila www.biorxiv.org/content/10.1...

Transcriptional interference gates monogenic odorant receptor expression in ants www.cell.com/current-biol...

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social www.science.org/doi/10.1126/...

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...

Is enhancer-driven gene regulation all wrapped up? www.nature.com/articles/s41...

Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function genesdev.cshlp.org/content/39/1...

What makes genes burst www.cell.com/trends/cell-...

[Review] Configuring the code: Enhancer-Promoter arrangement and transcriptional regulation in @jmolbiol.bsky.social #genesky www.sciencedirect.com/science/arti...

A de novo-originated gene drives rose scent diversification www.cell.com/cell/fulltex...

Driving a protective allele of the mosquito FREP1 gene to combat malaria www.nature.com/articles/s41...

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ www.nature.com/articles/s41...

New online: A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics

Range extender mediates long-distance enhancer activity www.nature.com/articles/s41...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu. Explained for non-experts!

🚨Our latest work on selfish centromeres is published @currentbiology.bsky.social 🐭🧬We found that the spindle checkpoint contributes to non-Mendelian segregation! Huge congrats to our lab manager, Zaak Walton, who led the project🎉 Free link: authors.elsevier.com/a/1lQzN3QW8S...

Delighted to share a new review paper from the lab. We summarized/discussed recent key findings in enhancer biology. Thanks Dan Larson and @tinekelenstra.bsky.social for this opportunity!! www.sciencedirect.com/journal/jour...

Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs www.nature.com/articles/s41...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation www.nature.com/articles/s41...

Mechanisms and timing of programmed DNA elimination in songbirds www.biorxiv.org/content/10.1...

It was a pleasure to write a N&Vs on @danielibrahim.bsky.social's latest paper in @natgenet.nature.com. Enhancers tend to stay put even if their sequence changes beyond recognition. Quoting Il Gattopardo, everything must change so that everything can stay the same: www.nature.com/articles/s41...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Sequence diversity lost in early pregnancy www.nature.com/articles/s41...

In the new #GENETICS #FlyBook article, @remlehmann.bsky.social and colleagues dive deep into the following #Drosophila embryonic germ cell development processes: germplasm assembly and function, pole cell formation and specification, and their migration to gonadal precursors. 🪰 buff.ly/lfKYEyg

🤗 Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...

Delighted to share a new preprint from the lab! We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila. www.biorxiv.org/content/10.1...

This looks so interesting - wish I had bandwidth to concentrate more www.nature.com/articles/s41...

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

Chromatin loops are an ancestral hallmark of the animal regulatory genome www.nature.com/articles/s41...

Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions www.biorxiv.org/content/10.1...

Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Some good doggos in this figure. Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans | Science www.science.org/doi/10.1126/...

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Happy to share our review with @akispapantonis.bsky.social in which we summarise and discuss our current understanding of enhancer-mediated gene activation in the context of the 3D genome: www.annualreviews.org/content/jour...

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

Online Now: Free introns of tRNAs as complementarity-dependent regulators of gene expression

Online Now: Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens

Since indirects are in the news again, and everybody and their dog has an opinion on how much "research overhead" should cost, here's an excellent book that explains where exactly the money goes. escholarship.org/uc/item/59p1...