We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!

“A program with a 0.5% success rate is not elite. It’s wasteful. Thousands of highly trained scientists will sink dozens of hours into writing proposals with vanishing odds of success. This is not just inefficient — it’s disrespectful of scientific labour.” Very well said @kamounlab.bsky.social!👏🏼👏🏼👏🏼

The EU will #GiveGenesAChance! 🇪🇺💚 www.europarl.europa.eu/news/en/pres... #Trilogue #NGTs

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

The hidden danger of Biorender (& the death of scientific illustration) A short thread 🧵

Es stehen erscheinende Tage für eine moderne, wissenschaftsbasierte Regulierung von Neuen Genomischen Techniken wie #CRISPR & Co. in der EU an. Worum es geht und was damit zu erreichen ist, haben wir 👇 nochmal zusammengefasst. #GiveGenesAChance

#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software ✅ Free 🔓 Open Source 🧬 More cloning methods than SnapGene 🤖 Can be automated with python 👨‍🔬 Built by a researcher — for researchers! 👉 Check it out at opencloning.org

Worked in a Drosophila genetics lab for the sole purpose of getting a letter of recommendation from the lab head for medical school. I loved being in the lab so much that I gave up on medical school and went to graduate school instead.

FLYDAY IS UPON US! #Flyday

1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...

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Excited to share our new paper out in Cell Reports Methods! @cp-cellrepmethods.bsky.social 🎉🎉🎉 We present EyaHOST, a modular Drosophila genetic system that enables precise and independent manipulation of tumours and host tissues to dissect tumour-host interactions. www.cell.com/cell-reports...

Funders can drive change. Authors can't. Authors are producers, not consumers. Producers don't decide demand, consumers do. Funders and research institutes must demand change of their authors, or withhold their funds. It's that simple. Funders have all the cards. 10/n

That's why funders hold the power here. Funders can decide to pay for services or not. They can decide to support authors who publish in for-profit journals, or not. They can decide to pay APCs in for-profit journals, or not. 9/n

Back on track: Funders hold all the cards. There's this flawed view that authors are consumers and journals are producers. Wrong. Funders and institutes are consumers. They contract authors to produce research, and they pay for journals to QC the work. Funders are the consumers. 8/n

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 23/31 Prompt FIREFLY Pdb: 2D1R Luciferase: firefly enzyme catalyzes a light-producing reaction that makes fireflies glow. Next: ROWDY Suggestions?

Delighted to share Array Assembler — a web tool for designing oligos for generating crRNA arrays for #Cas12 and #Cas13 systems. Input spacers and key plasmid details to generate an order-ready XLSX of oligos, streamlining array creation while minimising cost, time, and errors. Happy CRISPRing!

Lots of exciting PhD projects on offer at the LMB, including in our group 😊

Our lab is actively looking for PhD students and there is NOW an Open Call for PhD fellowship at the IRB Barcelona!!!!! phd.irbbarcelona.org

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

🧬Proud to share "Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs" my 1st first-author paper of my PhD, co-first-authored with the brilliant Dr. @mnwhittaker.bsky.social, is out today in Nature Biomedical Engineering! www.nature.com/articles/s41...

Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...

Looking forward to visiting @irbbarcelona.org and @milanlab.bsky.social on Friday. Will talk about our work updating the toolbox for engineering the fly genome. Come by if you are in the area. @araujolabub.bsky.social @gonzalezlabbcn.bsky.social @mirimiam.bsky.social @monicabettencourt.bsky.social

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social #CRISPR #Drosophila www.biorxiv.org/content/10.1...

Macron remarks are notable- some quotes: "We have been incredibly naive in entrusting our democratic space to social networks that are controlled either by large American entrepreneurs or large Chinese companies, whose interests are not at all the survival or proper functioning of our democracies."

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth. bit.ly/4gX6njF

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

What an exciting opportunity! Setting up a new lab with the great @madalenamrp.bsky.social at one of the best institutes around. Apply! 🧪🐟🧬

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back. I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨ 🔗 www.nikonsmallworld.com/galleries/20... #NikonSmallWorld #Microscopy #ScienceArt

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

Quick Drosophila question: I’m planning to integrate a construct on the second chromosome but would like to avoid the attP40 landing site. Any suggestion for a good alternative attP site on chromosome II? It’s for a skeletal-muscle–related project. Thanks! 🙂 Rui

The @fly-eds.bsky.social is having its general assembly this saturday at 13:30 at #EDRC2025 , please join us to discuss our society and to find out more about @flybase.bsky.social and the current funding crisis

‘On 18 August, judicial police showed up at the Research Institute in Health Sciences (IRSS) in Bobo-Dioulasso, a key partner in Target Malaria, to stage what scientists described as a “brutal, humiliating” raid.’ My story on mosquitoes, malaria and misinformation in @science.org 🧪

Huge thanks to all of our peer reviewers! Thanks to your efforts, we’ve helped to restore and preserve over 10,000 trees in ancient woodland! 🌳 #PeerReviewWeek #PRW2025 #notforprofit #ForestofBiologists

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export. www.biorxiv.org/content/10.1...

Ich suche eine*n TA für meine Arbeitsgruppe! Gern weitersagen 🤗🌾 #plantscijob

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

Wegen den Einschnitten der US-Regierung fürchten sich Wissenschaftler, dass die Flybase, eine zentrale wissenschaftliche Datenbank für die Forschung an der Fruchtfliege Drosophila melanogaster, verloren gehen könnte. Mein Text dazu in der heutigen F.A.Z.

www.thecrimson.com/article/2025... Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

Robert Hoffie @forscherrobert.bsky.social, head of Biotechnology & Genome Editing, at @leibnizipk.bsky.social joins our webinar on New Genomic Techniques to boost sustainability in Europe”! 🇪🇺🌾 Join us Sep 18 at 16:00 CEST! 📅 Free Registrations at forms.office.com/e/RXJwce0Y4G

The discussion of this paper is more fun to read than a scifi novel…wild!

So, let's unpack the whole mess of human hubris surrounding everything #AI and why this is so dangerous. The hubris demonstrated by GenAI companies is of course well documented. But it's also very evident in the criticism, and in a way that is distorting the real issues here. 1/7

I read the preprint. It's very beautiful work from Hadi Boukhatmi's group. They test how if at all #Drosophila can repair their #muscles. www.biorxiv.org/content/10.1...

New Zealand had some of the most restrictive laws when it came to genetically engineered food crops. This move once again demonstrates how the NZ Government makes Science-based decisions. Take note, European Union! #PlantGMOs #PlantNGTs #PlantScience #Agroculture #Sustainability #PlantBreeding