Our lab is actively looking for PhD students and there is NOW an Open Call for PhD fellowship at the IRB Barcelona!!!!! phd.irbbarcelona.org

🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

🧬Proud to share "Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs" my 1st first-author paper of my PhD, co-first-authored with the brilliant Dr. @mnwhittaker.bsky.social, is out today in Nature Biomedical Engineering! www.nature.com/articles/s41...

Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student Moritz Schlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk average! www.biorxiv.org/content/10.1...

Looking forward to visiting @irbbarcelona.org and @milanlab.bsky.social on Friday. Will talk about our work updating the toolbox for engineering the fly genome. Come by if you are in the area. @araujolabub.bsky.social @gonzalezlabbcn.bsky.social @mirimiam.bsky.social @monicabettencourt.bsky.social

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social #CRISPR #Drosophila www.biorxiv.org/content/10.1...

Macron remarks are notable- some quotes: "We have been incredibly naive in entrusting our democratic space to social networks that are controlled either by large American entrepreneurs or large Chinese companies, whose interests are not at all the survival or proper functioning of our democracies."

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth. bit.ly/4gX6njF

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

What an exciting opportunity! Setting up a new lab with the great @madalenamrp.bsky.social at one of the best institutes around. Apply! 🧪🐟🧬

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back. I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

You can read Mark's 2024 @dev-journal.bsky.social Review article here: doi.org/10.1242/dev....

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨ 🔗 www.nikonsmallworld.com/galleries/20... #NikonSmallWorld #Microscopy #ScienceArt

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

Quick Drosophila question: I’m planning to integrate a construct on the second chromosome but would like to avoid the attP40 landing site. Any suggestion for a good alternative attP site on chromosome II? It’s for a skeletal-muscle–related project. Thanks! 🙂 Rui

The @fly-eds.bsky.social is having its general assembly this saturday at 13:30 at #EDRC2025 , please join us to discuss our society and to find out more about @flybase.bsky.social and the current funding crisis

‘On 18 August, judicial police showed up at the Research Institute in Health Sciences (IRSS) in Bobo-Dioulasso, a key partner in Target Malaria, to stage what scientists described as a “brutal, humiliating” raid.’ My story on mosquitoes, malaria and misinformation in @science.org 🧪

Huge thanks to all of our peer reviewers! Thanks to your efforts, we’ve helped to restore and preserve over 10,000 trees in ancient woodland! 🌳 #PeerReviewWeek #PRW2025 #notforprofit #ForestofBiologists

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export. www.biorxiv.org/content/10.1...

Ich suche eine*n TA für meine Arbeitsgruppe! Gern weitersagen 🤗🌾 #plantscijob

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

Wegen den Einschnitten der US-Regierung fürchten sich Wissenschaftler, dass die Flybase, eine zentrale wissenschaftliche Datenbank für die Forschung an der Fruchtfliege Drosophila melanogaster, verloren gehen könnte. Mein Text dazu in der heutigen F.A.Z.

www.thecrimson.com/article/2025... Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

Robert Hoffie @forscherrobert.bsky.social, head of Biotechnology & Genome Editing, at @leibnizipk.bsky.social joins our webinar on New Genomic Techniques to boost sustainability in Europe”! 🇪🇺🌾 Join us Sep 18 at 16:00 CEST! 📅 Free Registrations at forms.office.com/e/RXJwce0Y4G

The discussion of this paper is more fun to read than a scifi novel…wild!

So, let's unpack the whole mess of human hubris surrounding everything #AI and why this is so dangerous. The hubris demonstrated by GenAI companies is of course well documented. But it's also very evident in the criticism, and in a way that is distorting the real issues here. 1/7

I read the preprint. It's very beautiful work from Hadi Boukhatmi's group. They test how if at all #Drosophila can repair their #muscles. www.biorxiv.org/content/10.1...

New Zealand had some of the most restrictive laws when it came to genetically engineered food crops. This move once again demonstrates how the NZ Government makes Science-based decisions. Take note, European Union! #PlantGMOs #PlantNGTs #PlantScience #Agroculture #Sustainability #PlantBreeding

🚨 Cool preprint alert. Molecular motors transport mRNAs to specific cellular locations. But the RNA 'zip codes' lack sequence consensus, so how are they read by the same machinery? @simonbullock11.bsky.social & @carter-lab.bsky.social labs provide answers... 🧪

Our work on rationally engineering allosteric protein switches is now out in Nature Methods: www.nature.com/articles/s41... Thanks a lot to @grunewald.bsky.social and @noahholzleitner.bsky.social for the comprehensive news and views: www.nature.com/articles/s41...

piRNAs are essential for transposon silencing in the animal germline. But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response? Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

I NEED to tell you the story of Tae Heung “William” Kim. He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease. He's a *legal permanent resident* of the United States. And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

Motherfucking wind farms…

My favourite ad: www.youtube.com/watch?v=2mTL...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

I am so happy to announce that our Drosophila testis multiome paper is now published in Nature Communications !!! I am very happy and proud of all who contributed, in particular Patrick and Pallavi who did an amazing job! www.nature.com/articles/s41...

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

Still waiting for bookmarks on this platform...

First preprint from the Bageritz Lab! Key contributions from Laura Schütze and @mariamusillo.bsky.social, and many helping hands across the lab. Thanks to @cosheidelberg.bsky.social & @sfb1324.bsky.social for their support. www.biorxiv.org/content/10.1... #MuscleDevelopment #WntSignaling #SFB1324

This Osprey is so majestic…. 🥰 And in the bird world this is considered a sick move….

Sometimes I can't tell whether LLM used too much training data from LinkedIn, or too many people use LLM to write LinkedIn posts.

The Baker lab @uwproteindesign.bsky.social did it again 😱 Protein design of IDPs binders www.ipd.uw.edu/2025/07/hitt...

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells. www.nature.com/articles/s41...

Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?

Drosophila for the win! When you can afford more than 3 subjects per experiment, your results get more reliable... www.nature.com/articles/d41...

A huge project has analysed more than 1,000 claims about the immunity of Drosophila fruit flies in scientific papers published over some 50 years go.nature.com/4lxhwJB