@eltsovmikhail.bsky.social
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IGBMC near Strasbourg DNA and chromatin in situ
https://x.com/EltsovMikhail
pinned post!
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
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Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
https://link.springer.com/article/10.1038/s44318-026-00701-7
2 months ago
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reposted by
Kazuhiro Maeshima
10 days ago
Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains rather than binding stably to nucleosomes as in the textbook model:
www.science.org/doi/10.1126/...
Congrats
@masaashimazoe.bsky.social
& all contributors! 🎉 2/
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I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model. Congratulations!
add a skeleton here at some point
5 days ago
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We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
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Direct visualization and tracing of chromatin folding in the Drosophila embryo - The EMBO Journal
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
https://link.springer.com/article/10.1038/s44318-026-00701-7
2 months ago
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Generate synthetic cryo-ET data and train your model for particle picking in real data. Impressive work by Mohamad Harastani:
www.nature.com/articles/s41...
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Template Learning: Deep learning with domain randomization for particle picking in cryo-electron tomography - Nature Communications
Particle picking is a key bottleneck in bridging structural and cell biology with cryo-electron tomography. Here, authors develop Template Learning, using domain-randomized simulations to train deep l...
https://www.nature.com/articles/s41467-025-63895-0
6 months ago
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A question for the experts: Can you recognize nucleosomes and linker DNA in this data? Find an updated version of our manuscript in
www.biorxiv.org/content/10.1...
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about 1 year ago
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