@olimpiabompadre.bsky.social
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Postdoc in the Trono lab@EPFL - interested in all things noncoding and genome regulation
This beautiful project is finally published! A fascinating study of how temporal use of enhancers sustains gene expression through development and shapes organ development! So proud to have been part of this project
add a skeleton here at some point
about 1 month ago
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reposted by
Simon Braun
2 months ago
New paper on bioRxiv by YounJu So in our lab! She shows that while SMARCD paralogs compensate for each other during neurodevelopment, each still drives distinct gene expression programs, explaining selective vulnerability of these SWI/SNF subunits in brain disorders.
www.biorxiv.org/content/10.6...
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Redundancy masks functional specificity of SMARCD paralogs in neurodevelopment
The SWI/SNF complex is an essential chromatin remodeler that regulates DNA accessibility during brain development. Through combinatorial assembly of subunits encoded by paralogous genes, SWI/SNF compl...
https://www.biorxiv.org/content/10.64898/2025.12.05.692564v1
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reposted by
Caetano Reis e Sousa
2 months ago
Key points on the need for continued animal use in scientific research.
www.theguardian.com/science/2025...
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Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
https://www.theguardian.com/science/2025/nov/30/why-we-have-to-continue-with-animal-testing-for-medical-research?CMP=Share_iOSApp_Other
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reposted by
Alexandre Mayran
3 months ago
Happy to present the final version of our Cadherin and gastruloid manuscript, online at
@cp-cellreports.bsky.social
.
www.cell.com/cell-reports...
Initially in BiorXiv (
www.biorxiv.org/content/10.1...
) 1/12
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Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven E-cadhe...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01339-7
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reposted by
Hannah Long
3 months ago
📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
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reposted by
eric lai
4 months ago
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at
flybase.org
, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
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FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
https://tinyurl.com/FlyBase
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reposted by
Tim Petzold
5 months ago
Excited to share that the final version of our work on Connexin 41.8 in HSPC specification is out now in
@biologyopen.bsky.social
! If you're curious about how a connexin helps turn endothelial cells into blood stem cells, please have a read!
journals.biologists.com/bio/article/...
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Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification
Summary: Cx41.8 is necessary to launch the haemogenic program and induce HSPC formation at the correct time during zebrafish development via a ROS-Hif-Notch-Gata2b pathway.
https://journals.biologists.com/bio/article/14/8/bio062118/368872/Connexin-41-8-governs-timely-haematopoietic-stem
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reposted by
Claudio Cantù
7 months ago
A 6-year long study from the Lab is finally out
@genomeresearch.bsky.social
Mastered by
@annanordin.bsky.social
in collaboration with Chaitali Chakraborty from
@remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
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Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
https://genome.cshlp.org/content/early/2025/07/13/gr.279684.124.full.pdf+html
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reposted by
Axel Visel
7 months ago
No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of
@fany-real.bsky.social
@stemundi.bsky.social
@dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo
#SingleCell
#BatWings
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The final chapter of my Pitx1 adventure is out! 1 simple question:”How do SVs that shorten enhancer-promoter distance affect limb development?” We find the impact on transcription, cell populations, epigenetics, and chromatin structure. A labour of joy with
@guandrey.bsky.social
& all co-authors.
add a skeleton here at some point
7 months ago
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reposted by
Olga Rosspopoff, PhD
8 months ago
🚨 Check out the latest from
@trono-lab.bsky.social
showing how evolutionarily young transcription factors contribute to human cell cycle regulation! Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
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Evolutionarily recent transcription factors partake in human cell cycle regulation
Pulver and Forey et al. generated a novel atlas reporting (1) gene expression over the cell cycle and (2) how systematic gene depletion affects cell cycle progression. They thereby identified evolutio...
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00179-X
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reposted by
Axel Visel
8 months ago
Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here
@berkeleylab.lbl.gov
,
@anshulkundaje.bsky.social
,
@anusri.bsky.social
A 🧵 (1/n) Free access link:
rdcu.be/erD22
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reposted by
Daniel Ibrahim
9 months ago
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
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Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
https://rdcu.be/enVDN
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reposted by
Danica Milovanović
9 months ago
New preprint of
@trono-lab.bsky.social
and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1...
#TEsky
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