Danica Milovanović
@1995dana.bsky.social
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📥 228
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scientist | pacifist | transposable elements | evo-devo PhD
@trono-lab.bsky.social
pinned post!
New preprint of
@trono-lab.bsky.social
and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1...
#TEsky
6 months ago
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Danica Milovanović
EMBL Events
4 days ago
Welcome to Day 3 of
#EMBOMobileGenome
🙌🏼 While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸 ➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)
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Danica Milovanović
Svetlana Dodonova
13 days ago
Lab’s first paper is out!! We show the first structures of
#Asgard
#chromatin
by
#cryo-EM
🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across
#Archaea
, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here:
www.cell.com/molecular-ce...
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Danica Milovanović
Vivien Horvath
15 days ago
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
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Alejandro Montenegro
23 days ago
"Our study reveals that the current understanding of chromatin states is extensively incomplete, and newer in situ chromatin fragmentation-based techniques are preferred for investigating repetitive elements and retrotransposons"
www.sciencedirect.com/science/arti...
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CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies of chromatin features by eliminating the need for up-front purifica…
https://www.sciencedirect.com/science/article/pii/S2589004225020188
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Beautiful 🦋
add a skeleton here at some point
about 1 month ago
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Danica Milovanović
Guillaume Andrey
4 months ago
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to
@olimpiabompadre.bsky.social
, to Marie Kmita's lab, and to all the co-authors.
www.nature.com/articles/s41...
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Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
https://www.nature.com/articles/s41467-025-61615-2
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Danica Milovanović
Olga Rosspopoff, PhD
5 months ago
🚨 Check out the latest from
@trono-lab.bsky.social
showing how evolutionarily young transcription factors contribute to human cell cycle regulation! Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...
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Evolutionarily recent transcription factors partake in human cell cycle regulation
Pulver and Forey et al. generated a novel atlas reporting (1) gene expression over the cell cycle and (2) how systematic gene depletion affects cell cycle progression. They thereby identified evolutio...
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00179-X
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Danica Milovanović
FragileNucleosome
5 months ago
🔔Upcoming Wednesday, June 4th! Join us for another
#FragileNucleosome
series! Two amazing talks by
@1995dana.bsky.social
&
@chrishsiung.bsky.social
! If you haven’t jooned for any of 2025 talks, register here:
us06web.zoom.us/webinar/regi...
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New preprint of
@trono-lab.bsky.social
and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1...
#TEsky
6 months ago
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reposted by
Danica Milovanović
bioRxiv Genomics
6 months ago
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity
https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1
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Danica Milovanović
Tilly S Scott
12 months ago
And with that the afternoon of
@gensocuk.bsky.social
short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵
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