📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word! academicjobsonline.org/ajo/jobs/30607

Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬

New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain. doi.org/10.1002/advs...

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

1/3 So pleased to have this latest installment of “the retrotransposon storm” submitted and on biorxiv. This work was driven by Shreevidya Korada, an amazing PhD student in Roger Sher’s lab, co-mentored by me. @mollygale.bsky.social was an awesome collaborator. www.biorxiv.org/content/10.1...

📣 New pre-print from the lab: 👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM 📝 Read the #BioRxiv here: doi.org/10.1101/2025...

Transposable elements are a major driver of intron gain in eukaryotes, and are capable of transmission between diverse species #HGT #evolution - www.pnas.org/doi/10.1073/...

Great opportunity with a great lab and great PI in an amazing research environment. I highly recommend it!!🧠🧬

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...

🔬👩‍🔬What sparked your interest in science?👨‍🔬🧫 For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration! 📖 Read more: www.stemcellcenter.lu.se/article/unis...

DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis https://www.biorxiv.org/content/10.1101/2025.03.11.642717v1

New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky biorxiv.org/content/10.110…

Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...

New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. doi.org/10.1101/2025...

Online now! TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states 🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues @ilariapanzeri.bsky.social @andrewpospisilik.bsky.social 👇 www.nature.com/articles/s43...

That's a beautiful and important paper

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵

New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social. LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development www.biorxiv.org/content/10.1...

🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics

It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!

Don't miss the first CSH Asia meeting on transposons in April in Suzhou, China. Truly fantastic line-up! Abstract deadline at the end of the month... (why is not everyone working on transposons?).

How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction. journals.plos.org/plosbiology/...

To kick start the New Year, I'm delighted to share the lab's first preprint - now online: biorxiv.org/cgi/content/... See below for a couple of highlights👇 Any feedback is welcome! "TEsky" HAPPY NEW YEAR to everyone! 🥂

Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...

How does the ORF1p perform its multiple functions to facilitate LINE1 retrotransposition? And what enables its ability to also facilitate replication of other retrotransposons? Find out in our newly published paper in Nucleic Acids Research doi.org/10.1093/nar/...

A homozygous SVA retrotransposon insertion is discovered to be likely the most common mutation in ASPA (encodes aspartoacylase) underlying Canavan disease. 1/ Gonzalez, Bell, et al. medRxiv www.medrxiv.org/content/10.1...

We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here: www.lunduniversity.lu.se/article/52-m...

🎉 Prof. Johan Jakobsson, Director of Lund Stem Cell Center, and an international team have been awarded 52M SEK by @asapresearch.bsky.social to explore "jumping genes" in #ParkinsonsDisease. Congrats @jakobssonlab.bsky.social & collaborators! 🔗 Read more: www.stemcellcenter.lu.se/article/52-m...

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

Measuring biological age using omics data go.nature.com/3n0hCfZ #Review by Jarod Rutledge, Hamilton Oh & Tony Wyss-Coray #epigeneticclocks #agingclocks Free to read here: rdcu.be/cPR6u

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

🏆 Big news! "Melanogaster: Catch The Fly!" #CitizenScience project is now a #FallingWalls2024 Science Breakthrough winner Congratulations to @gonzalezlabbcn.bsky.social and to the #LaCiènciaalTeuMón team!

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder @jakobssonlab.bsky.social @vivienhorvath.bsky.social #TEworldwide #Transposons #XDP #NSMB + the volume has the cutest cover 🦔

🗓️ Mark your calendar: May 19-21, 2025 There will be a great #neurogenomics conference @humantechnopole.bsky.social in Milan (@harschnitz.bsky.social ‬ is one of the organizers). Grateful to have been invited alongside (some joined 🦋 recently): @silvianeuro.bsky.social @sergiuppasca.bsky.social 1/

Postdoctoral position in Human Systems Immunology #ScienceJobs #AcademicSky jobrxiv.org/job/lund...

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...

Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out! www.mghlab.org/software

Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab www.embl.org/about/info/c...

Hello new followers! Will start posting here more often. Reposting our recent preprint on intercellular tau transmission! 🧪🧠 #neuroscience #cellbiology

Incredible resource for DNA binding protein specificity from the Codebook consortium. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... Am reading these in detail & will have a lot to say. Stay tuned for thoughts.

With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here: go.bsky.app/TKp9YAn I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.