New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan. www.biorxiv.org/content/10.1...

Excited to post my first #JobOffer! I am looking for a research technician to help me build new projects from the grounds up at @cabd-upo-csic.bsky.social We will use medaka to study how organs can be reprogrammed! Details on how to apply below 👇 #JobOffer #ScienceJobs #EvoDevo #GeneRegulation

ICYMI, the recordings of our #DevPres webinar on gene regulation are now available. Check out the talks from @dev-journal.bsky.social PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social. thenode.biologists.com/catch-up-on-... #devbio 🎥

💥 New preprint! 💥 We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠 What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org #Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

Thank you for the interview @dev-journal.bsky.social! Very excited to be part of the Pathway to Independence program Interested in my research? I'll be presenting my postdoc work at the 'Development presents' webinar, tomorrow afternoon: thenode.biologists.com/development-...

Excited to share our latest work!! 🌟🌟 Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

Interested in transposable elements in mammalian preimplantation development? It's not too late to register for the 'Development presents' webinar next Wednesday. Together with Anzy @anzymiller.bsky.social who will talk about her postdoc work as well!

Two of Development’s PI fellows, Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, will be giving talks in our upcoming #DevPres webinar on gene regulation. 🗓️Wednesday 27 August, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...

Our featured article: Epigenome dynamics in early mammalian embryogenesis by Adam Burton & Maria-Elena Torres-Padilla go.nature.com/45UA8Ob

Interested in how cells read biological time? Next week I'm talking about my recently published work on how protein expression oscillations are read by cells and their impact on the timing of cell differentiation. Link below to register!

Our next #DevPres webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, chaired by James Gahan @jgahan.bsky.social. 📆 27 August, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...

I spoke with @reinierprosee.bsky.social about my journey in science, and my hope and dreams. Thank you @dev-journal.bsky.social for this oppotunity! I'm looking for a home for the Ewe lab. Let's talk if you're hiring! :) journals.biologists.com/dev/article/...

My Pathway to Independence interview is now live on @dev-journal.bsky.social ! I had a great time speaking with @amjeve.bsky.social about my research journey and what's ahead journals.biologists.com/dev/article/...

In case you've ever wondered, I talked with @amjeve.bsky.social about science, myself, and the future of #DevBio as part of the Pathway to Independence Fellowship @biologists.bsky.social 🧪 journals.biologists.com/dev/article/...

My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you. journals.biologists.com/dev/article/...

Very happy that this (last?) piece of my PhD time in the Dekker lab is now out in Genome Research! genome.cshlp.org/content/earl... @jobdekker.bsky.social @pablonavarrolab.bsky.social @genomeresearch.bsky.social

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

New preprint of @trono-lab.bsky.social and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat www.biorxiv.org/content/10.1... #TEsky

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

📢The peer-reviewed version of our work on TEs driving innovation of F-box genes is out now on @molbioevol.bsky.social. 🎉 paper here: academic.oup.com/mbe/article/... Check my previous, but still up-to-date 🧵 to read the highlights. #TEsky #evosky #Celegans

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Very happy to see @marliesoomen.bsky.social in the path to independence programme of @dev-journal.bsky.social 🎊

Introducing the 2025 PI Fellows of our Pathway to Independence Programme Over the next year, we will be supporting this talented group of eight postdocs, providing training, mentorship and networking opportunities as they apply for independent positions. journals.biologists.com/dev/pages/pi...

Very excited (and honored!) to be part of this amazing group of scientists! Looking forward to going through the Pathway to Independence program together

In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis. Learn more here: ➡️ tinyurl.com/gd352270

Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social Very happy to see this come to fruition- Look forward to feedback from colleagues ! More 👉 www.cell.com/cell/fulltex...

How does the genome find its place in the 3D space of the nucleus after fertilization? Out now @cellcellpress.bsky.social: cell.com/cell/fulltext/… 👇 A thread 👇

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today! Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes! With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs. See thread below:

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

we've put a Review together 👇 Just came out at www.nature.com/articles/s41... hoping it is useful for those in the field but also for those not in the field who would like an overview on chromatin/epigenetics/replication/nuclear organisation in early embryos Enjoy :) - feedback welcome

Registrations are now open for the next @embo.org EvoChromo meeting in December. meetings.embo.org/event/24-evo... Join us in beautiful Costa Brava to discuss chromatin evolution! Co-organized with @tobiaswarnecke.bsky.social @sandraduharcourt.bsky.social @levine-lab.bsky.social and Nick Irwin

My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT! For more information see here: gahanlab.com tinyurl.com/34xke35d

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

Very happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!

New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky biorxiv.org/content/10.110…

I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less! authors.elsevier.com/c/1kjdaL7PXu... How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it. #Retrovirus #koala #piRNA More below 👇

🚨New Paper Alert! Check the news about the sucessful research led by our Director at IES here: 👉 t1p.de/d87p5. Original paper at @genesdev.bsky.social: genesdev.cshlp.org/content/earl... Congrats to Clara Hermant, Michel Mourra-Diaz, @marliesoomen.bsky.social, Mrinmoy Pal & rest of authors!

I’m excited to share a new preprint from some of my work in the lab of @toddmacfarlan.bsky.social ! 😄 We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice

Very happy to share the latest story from @metorrespadilla.bsky.social lab by Clara and Mich (both not on bsky)! Anyone interested in TEs in early embryos; have a look! Not all mERVL LTRs are the same 👀 Proud to have contributed a small part of the analysis! genesdev.cshlp.org/content/earl...

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

Our first deep dive into TEs and piRNAs in African cichlids is finally published! genomebiology.biomedcentral.com/articles/10.... rdcu.be/d69S5 Our main findings below 🧵 #TEsky

I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here: www.biorxiv.org/content/10.1... Highlights and key findings from our study in the thread below 👇

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

🚨New paper alert, at Cell Press! 🚀 Excited to share groundbreaking research from Helmholtz Munich led by @metorrespadilla.bsky.social; @marliesoomen.bsky.social & @diego-rt.bsky.social. They've uncovered ancient viral DNA's role in early embryonic development! 👉 Original paper: shorturl.at/D7eCz