Cozy day for some transposon research 🤍❄️ #LundUniversity #snow

Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠 #ASAP @jakobssonasap.bsky.social

#EMBOMobileGenome Session 2 on transposon regulation 🧬 ➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden) We love a good Q&A session as well! 🙋🏼 @chdouse.bsky.social @lundstem.bsky.social @embl.org

Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌

@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟

Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.

💥 New preprint! 💥 We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠 What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org #Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs

Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟 Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...

Excited to share our latest work!! 🌟🌟 Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

⏰ Abstract deadline for 'The mobile genome' is 29 July! 👉 https://s.embl.org/mge25-01-bl Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍 ⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out! #EMBOMobileGenome

These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next! #ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...

Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social

Popcorn worthy research at #CRNPhoenix2025 with @jakobssonasap.bsky.social 🍿 #ParkinsonsDisease #PD #TEsky

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium! We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes #NIHfundedResearch www.cell.com/cell-reports...

In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes. Check out the full #preprint: shorturl.at/TJ9BK

Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics

CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching. www.csh-asia.org?content/2544

Secret santa @jakobssonlab.bsky.social 🧬🎄

Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out! www.mghlab.org/software

💥🦊 So proud of being part of this team!

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder @jakobssonlab.bsky.social @vivienhorvath.bsky.social #TEworldwide #Transposons #XDP #NSMB + the volume has the cutest cover 🦔

Gorgeous. Plain gorgeous jumping genes 💜👾🧬 #TEsky

Today we are showing high school students how cool things we can do using #nanopore sequencing at the #unistemday at the Lund Stem Cell Center 🧬👩‍🔬🦠🧪

🐒 The Tale of Our Long Lost Tail Insertion of a short DNA sequence into a gene that controls tail development could explain tail loss in the common ancestor of apes. A mobile DNA sequence could explain tail loss in humans and apes 🏺🧪 www.nature.com/articles/d41...

How cool! Our paper about endogenous retroviruses and traumatic brain injury got featured at the TWiN podcast! 🦠 I loved hearing the discussion about it 🧠 If you are interested 👉 youtu.be/599V0xyrxgQ?... TEworldwide MicrobeTV

An exciting line up for the upcoming “Neuroepigenetics in health and disease” Segerfalk Symposium here in Lund University 🧬🧠 Probably of interest for some of you in #TEworldwide! More info 👉 www.neuroscience.lu.se/events/seger...

the TE Hub is on BlueSky! bsky.app/profile/tehu... Don't know about TE Hub? It's a community-based ressource for everything #transposons and #bioinformatics. Let's connect!

I know so many colleagues that suffer from the terrible ailment on the top-right of this snapshot...

New to bluesky and with 7 followers 😂 but I wanted to scream from the rooftop that I DEFENDED MY PHD! 🎉🥂 Million thanks to @brancolab.bsky.social for the fantastic discussion and day, and to @jakobssonlab.bsky.social for pushing me and having my back all these years! 🧬🧠