Miguel Branco
@brancolab.bsky.social
📤 1825
📥 1045
📝 111
Transposons and epigenetics.
https://brancolaboratory.com/
reposted by
Miguel Branco
Aris Katzourakis
about 14 hours ago
Three jobs in our shiny new building:
add a skeleton here at some point
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4
reposted by
Miguel Branco
Artem Ilin
1 day ago
Kicked off a series on
#Drosophila
TE discovery and naming. The first post covers elements that predate the term "mobile element", and more.
artemilin.dev/posts/te_nam...
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Drosophila TE name origins, Part 1 – Postdoc Postpunk
https://artemilin.dev/posts/te_names_1/
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reposted by
Miguel Branco
Rebecca Mosher
8 days ago
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague!
www.biology.ox.ac.uk/article/we-a...
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We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities
https://www.biology.ox.ac.uk/article/we-are-hiring
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reposted by
Miguel Branco
Alex de Mendoza
12 days ago
Very happy to have contributed to this review on "non-CG"
#methylation
in animals now out in
@natgenet.nature.com
. Working again with
@obog.bsky.social
and Tirsa is always a pleasure. We think this not so well studied form of methylation should be more widely considered, please read:
rdcu.be/eFAEk
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Non-CG DNA methylation in animal genomes
Nature Genetics - This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a...
https://rdcu.be/eFAEk
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reposted by
Miguel Branco
The Dunn School, Oxford
13 days ago
We're hiring (again)! We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly) If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
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reposted by
Miguel Branco
Patrick Nielsen Hayden
20 days ago
This, from
@anthonymoser.com
, is outstanding. (H/t
@lecagle.bsky.social
.) "The makers of AI aren’t damned by their failures, they’re damned by their goals."
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I Am An AI Hater
I am an AI hater. This is considered rude, but I do not care, because I am a hater.
https://anthonymoser.github.io/writing/ai/haterdom/2025/08/26/i-am-an-ai-hater.html
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reposted by
Miguel Branco
Maxim Greenberg
19 days ago
🚨 🐜 is there a Bluesky starter pack for researchers who don’t study ants but who get lightheaded every time there’s an awesome ant paper? CC
@mariusw.bsky.social
@jrichardalbert.bsky.social
www.nature.com/articles/s41...
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One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
https://www.nature.com/articles/s41586-025-09425-w
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reposted by
Miguel Branco
Iqbal Dulloo
20 days ago
Having spent significant time here, the environment and support are truly amazing, and in my opinion, the best you can have in Oxford.
add a skeleton here at some point
0
4
4
reposted by
Miguel Branco
Transposon and Cancer Epigenetics Group
20 days ago
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis.
www.cell.com/trends/cance...
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Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis
Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00187-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405803325001876%3Fshowall%3Dtrue
5
46
22
reposted by
Miguel Branco
Alex Eve
25 days ago
If you've had a half-finished Node post draft in the back of your mind for a while, now there's some incentive to get it finished & out there for the community. Remember that the Node is for all
#devbio
&
#stemcell
researchers. Register & you're free to post anything relevant without intervention.
add a skeleton here at some point
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1
1
reposted by
Miguel Branco
Stefan Schoenfelder
4 months ago
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with
@guenesdoganlab.bsky.social
:
www.biorxiv.org/content/10.1...
🧵 below
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Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...
https://www.biorxiv.org/content/10.1101/2025.06.01.657118v1
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New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.
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ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface
This study reveals that ADAR1, an RNA-editing enzyme, fine-tunes immune responses in the placenta by preventing the accumulation of immunogenic double-stranded RNAs (dsRNAs) from interferon-stimulate...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202505491#
about 1 month ago
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reposted by
Miguel Branco
Stylianos Lefkopoulos (he/him)
about 1 month ago
🥂Congrats to Gao, Li & co for their new
@natcellbio.nature.com
study: they derive
#trophectoderm
stem cells from 32-cell mouse
#embryos
. These cells represent an early trophectoderm state, develop into
#placenta
cells and organoids and contribute to blastoid generation.
rdcu.be/eAKzp
bit.ly/4fyZ9Sg
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Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
https://bit.ly/4fyZ9Sg
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24
6
reposted by
Miguel Branco
Manuel Irimia
2 months ago
🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab
@upf.edu
&
@crg.eu
(Barcelona) and the Sander lab
@mdc-berlin.bsky.social
(Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇
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https://www.upf.edu/documents/2869130/0/Informal_ad-LaCaixa-Irimia.pdf
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reposted by
Miguel Branco
Alex de Mendoza
about 2 months ago
Happy to see our latest work out in
@molbioevol.bsky.social
. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾:
academic.oup.com/mbe/advance-...
🧵 1/7
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Repressive cytosine methylation is a marker of viral gene transfer across divergent eukaryotes
Abstract. Cytosine DNA methylation patterns vary widely across eukaryotes, with its ancestral roles being understood to have included both transposable ele
https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaf176/8213644
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reposted by
Miguel Branco
Typas Lab
about 2 months ago
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
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Group Leader – Molecular Systems Biology Unit
Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/details/Group-Leader----Molecular-Systems-Biology-Unit_JR2062
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reposted by
Miguel Branco
Clément Goubert
2 months ago
How the complex issue of delineating
#Transposons
families plays out in the interpretation of epigenetic experiments. Congrats Xun Chen and
@guilbourque.bsky.social
for leading this work, and thank you for having me on this!
www.science.org/doi/10.1126/...
#TEsky
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A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
https://www.science.org/doi/10.1126/sciadv.ads9164?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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23
13
reposted by
Miguel Branco
The Royal Society
2 months ago
Come and work at the Royal Society! We have several roles open including Fellowship Officer in our Central Secretariat, and Senior Designer in our Communications team. Find out more on our careers page:
#RSCareers
careers-royalsociety.icims.com/jobs/search?...
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7
2
reposted by
Miguel Branco
Stefan Schoenfelder
2 months ago
🚨 New paper alert 🚨 I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd. Short 🧵
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Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology
Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-025-03658-8
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Haig Kazazian (in memoriam), delivered by Jef Boeke and John Moran at FASEB meeting. A giant in the field.
#TEs
#ForgotTheMeetingHashtag
2 months ago
0
11
1
reposted by
Miguel Branco
Ed Chuong
2 months ago
Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!
jobs.colorado.edu/jobs/JobDeta...
🧪🧬
#TESky
#interferosky
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reposted by
Miguel Branco
Deborah Bourc’his
2 months ago
Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop. ☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
add a skeleton here at some point
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15
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reposted by
Miguel Branco
The Loke Centre for Trophoblast Research
2 months ago
Attended our Annual Meeting last week? Any thoughts or reflections? Jump over to our LinkedIn to let us know!
www.linkedin.com/feed/update/...
0
2
1
reposted by
Miguel Branco
Vicki Metzis
2 months ago
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups
@mrc-lms.bsky.social
Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇
lms.mrc.ac.uk/work/vacanci...
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MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
https://lms.mrc.ac.uk/work/vacancies/mrc-postdoctoral-research-scientists-x-5/
0
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reposted by
Miguel Branco
Lund Stem Cell Center
2 months ago
🌍 Lund University is hiring! Join top research environments like ours at Lund Stem Cell Center. Faculty roles in life sciences & biomedicine are now available.
#AcademicJobs
📢 Positions across immunology, neuroscience & more: 🔗
lu.varbi.com/en/what:job/...
🔗
www.lunduniversity.lu.se/article/lund...
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This might not be an impartial opinion, but I think she's extraordinary in a lot of ways.
add a skeleton here at some point
2 months ago
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This is insane and amazing in equally high measures
add a skeleton here at some point
2 months ago
0
1
1
reposted by
Miguel Branco
Juliane Glaser
3 months ago
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published
@natgenet.nature.com
🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details:
www.nature.com/articles/s41588-025-02248-5
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Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
https://www.nature.com/articles/s41588-025-02248-5
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😲
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Cell type and cell signalling innovations underlying mammalian pregnancy - Nature Ecology & Evolution
Single-cell transcriptomes from the fetal–maternal interface of six species of mammals reveal a conserved gene expression signature of invasive trophoblast, stepwise evolution of decidual stromal cell...
https://www.nature.com/articles/s41559-025-02748-x
3 months ago
0
9
3
reposted by
Miguel Branco
Tugce Aktas
3 months ago
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
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Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
https://www.nature.com/articles/s41580-025-00867-8
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reposted by
Miguel Branco
Michelle Percharde
3 months ago
The Chromatin And Development lab are hiring a postdoc! Come join us; we are a happy and hard working team
@mrc-lms.bsky.social
in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!
lms.mrc.ac.uk/work/vacanci...
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MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
https://lms.mrc.ac.uk/work/vacancies/mrc-postdoctoral-research-scientist-5/
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reposted by
Miguel Branco
3 months ago
Dear Mobile DNA Researchers, The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts. Info, registration, and abstract submission:
www.eventsquid.com/event/28372
#MobileDNA
#MobileGeneticElements
0
2
8
reposted by
Miguel Branco
Matthew Cobb
3 months ago
To that there London in my shorts, to give my Wilkins-Bernal-Medawar Lecture to the Royal Society (not in shorts). Will be live-streamed on YouTube and later uploaded. Details:
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The life and times of Francis Crick, or does it matter who does science? | Royal Society
Wilkins-Bernal-Medawar 2024 Prize Lecture delivered by Professor Matthew Cobb
https://royalsociety.org/science-events-and-lectures/2025/06/wbm-prize-lecture/
1
33
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reposted by
Miguel Branco
Kasia Siudeja
3 months ago
Happy that our preprint from early this year, uncovering the regulation a somatically "hot" endogenous retroelement locus, has now found its home in
@narjournal.bsky.social
. "TEsky"
doi.org/10.1093/nar/...
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An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility
Abstract. Retrotransposons, multi-copy sequences that propagate via copy-and-paste mechanisms, occupy large portions of eukaryotic genomes. A great majorit
https://doi.org/10.1093/nar/gkaf485
9
58
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reposted by
Miguel Branco
Claire Rougeulle
3 months ago
Join us in the
#institutcurie
exceptional environment to explore the mysteries of X chromosome regulation in early human development
add a skeleton here at some point
0
2
4
reposted by
Miguel Branco
Institute of Molecular Biotechnology
3 months ago
We are
#hiring
! Join the Bioinformatics Services team as a Staff Bioinformatician and contribute to our mission of advancing bioinformatics-driven research, built on cutting-edge computational infrastructure. Apply below!
1
6
6
reposted by
Miguel Branco
bioRxivpreprint
3 months ago
LINE-1 ORF1p is a shared and immunogenic antigen in cancer
https://www.biorxiv.org/content/10.1101/2025.06.11.659092v1
0
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1
Congratulations
@emiliebrasset.bsky.social
and colleagues! Great work.
add a skeleton here at some point
3 months ago
0
6
1
reposted by
Miguel Branco
Molly Gale (Gale-Hammell Lab)
3 months ago
🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences
#TransposonDay2025
5
479
202
reposted by
Miguel Branco
Greg Priest
3 months ago
Barbara McClintock was born OTD in 1902. “I start with the seedling, and I don't want to leave it. I don't feel I really know the story if I don't watch the plant all the way along. So I know every plant in the field. I know them intimately, and I find it a real pleasure.” 🌱🐋🧪
#HistSTM
#PhilSci
3
64
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reposted by
Miguel Branco
ravindra-raut.bsky.social
3 months ago
🧬Happy Transposon Day! 🎉Each year on the 16th of June we commemorate the birthdate of the founder of transposable element research, Barbara McClintock (1902-1992).
#TransposonDay2025
#MobileDNAjournal
0
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reposted by
Miguel Branco
FocalPlane
3 months ago
@helenzsci.bsky.social
interviews
@retropz.bsky.social
, Research Integrity & Training Advisor
@cruk-mi.bsky.social
. They discuss Andrew’s career path; what research integrity means & its link to mental health; & Andrew’s thoughts on generative AI.
focalplane.biologists.com/2025/06/16/a...
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An interview with Andrew Porter, Research Integrity and Training Advisor - FocalPlane
An interview with Andrew Porter, Research Integrity and Training Advisor - Interviews
https://focalplane.biologists.com/2025/06/16/an-interview-with-andrew-porter-research-integrity-and-training-advisor/
0
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Trophoblast and endometrial stromal cells fuse?! I had no idea.
pubmed.ncbi.nlm.nih.gov/40509769/
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Syncytin-1 Is Responsible for the Fusion Between Human Trophoblasts and Endometrial Stromal Cells - PubMed
Syncytiotrophoblasts (STs) are multinucleated cells formed by the fusion of trophoblasts and play critical roles in placental development and function. Retrovirus-derived fusogenic proteins, known as ...
https://pubmed.ncbi.nlm.nih.gov/40509769/
3 months ago
0
8
6
reposted by
Miguel Branco
ME Torres-Padilla
3 months ago
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!! Please distribute :) 🙂
add a skeleton here at some point
0
23
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reposted by
Miguel Branco
QMUL Centre for Epigenetics
3 months ago
Our next guest speaker webinar is happening on Friday, June 20th at 15:30 GMT. Parinaz Mehdipour
@parinazmehdipour.bsky.social
will give a talk on 'Triggering anti-viral immune responses against cancer through epigenetic and epitranscriptomic modifications'
teams.microsoft.com/l/meetup-joi...
0
3
1
reposted by
Miguel Branco
Mario Iurlaro
4 months ago
We're hiring a postdoc! Come join my lab @Novartis Oncology in Basel 🇨🇭, and employ genome engineering and functional genomics approaches to study how oncogenic Transcription Factors function at the molecular level (and how to drug them) 3+1 years! Apply! Please RP
www.novartis.com/careers/care...
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Discovery Postdoctoral Fellow in Cancer Functional Genomics
About the roleWe are thrilled to open applications for our Discovery Fellowship track of the Novartis Postdoctoral Fellowship Program.Come join Novartis Biomedical Research as a Discovery Postdoctoral...
https://www.novartis.com/careers/career-search/job/details/req-10054303-discovery-postdoctoral-fellow-cancer-functional-genomics
0
10
11
reposted by
Miguel Branco
Surfin' NuRD
3 months ago
Postdoc post in my lab from Autumn this year
@lsiexeter.bsky.social
@exeter.ac.uk
#Chromatin
#StemCells
#Enhancer
#NeuralCrest
#Transcription
#CellFate
#NuRDIsTheWord
Apply and/or get in touch!
add a skeleton here at some point
0
9
15
reposted by
Miguel Branco
Josh Dubnau
4 months ago
1/3 So pleased to have this latest installment of “the retrotransposon storm” submitted and on biorxiv. This work was driven by Shreevidya Korada, an amazing PhD student in Roger Sher’s lab, co-mentored by me.
@mollygale.bsky.social
was an awesome collaborator.
www.biorxiv.org/content/10.1...
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LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell death.
A key pathological feature of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) is the loss of nuclear localization and the accumulation of cytoplasmic inclusions of hyperphosphory...
https://www.biorxiv.org/content/10.1101/2025.06.06.658329v1
1
20
9
reposted by
Miguel Branco
Alexis Verger 🧬🧫🧪
3 months ago
2nd Meeting on Epigenetics & Epigenomics - 24th - 26th September, Brussels 🇧🇪 Speakers Line-up looks fantastic including
@adelmanlab.bsky.social
@kjarmache.bsky.social
@mariekeoudelaar.bsky.social
@tinekelenstra.bsky.social
@lucianodicroce.bsky.social
www.xcellsconferences.com/epigenetics2...
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Epigenetics 2025 | Xcells Conferences
https://www.xcellsconferences.com/epigenetics2025/speakers
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reposted by
Miguel Branco
The EMBO Journal
4 months ago
REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!”
#TransparentPeerReview
Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
@juliusbrennecke.bsky.social
et al
www.embopress.org/doi/full/10....
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