If you’ve heard me talk in the past ~5 years, you will know I have developed an obsession with acrocentric chromosomes. This is all of that, condensed into one paper. I will do a full thread in the new year, but for those that want something to read over the holidays, have at it. Such a cool story!

Human acrocentric chromosome short arm de novo mutation and recombination https://www.biorxiv.org/content/10.64898/2025.12.16.694519v1

Complete genomes of a multi-generational pedigree to expand studies of genetic and epigenetic inheritance https://www.biorxiv.org/content/10.64898/2025.12.14.693655v1

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

ooh good call

These are the types of changes needed at funding agencies.

And of course, if you haven’t already, watch ‘Quest for Fire’. It’s great fun! m.imdb.com/title/tt0082...

Wow!!!!!

This is shocking stuff. John Quackenbush has been brilliant since forever. www.statnews.com/2025/12/05/r...

Proud to announce that four Queen Mary researchers have secured prestigious #ERCCoG Consolidator Grants: Dr Stefaan Verbruggen, Prof Claudia Langenberg, Dr Xuekun Lu and Dr Alexandre De Mendoza Soler. Find out more: www.qmul.ac.uk/media/news/2...

Indeed interesting!

Human gene maps contain major blind spots that leaves out a vast majority of the world's biological diversity, according to a new study led by the CRG's @rodericguigo.bsky.social with @bsc-cns.bsky.social. The researchers uncovered tens of thousands of new transcripts and entirely new genes.

(S)-cargot (R)-cargot

this is mesmerizing

🤯

This looks very interesting!

Happy birthday to the Soviet linguist Yuri Knorozov who casually deciphered the Mayan script in 1952 and got pissed when editors removed his cat as co-author on papers or cropped her out of his author headshot (the only picture of himself he even liked)

Cool stuff!

Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...

Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity

AI tells you what you want to hear, statisticians usually tell you what you don't want to hear

Oooh, very interesting!

Beautiful work.

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...

Worth watching m.imdb.com/title/tt3859...

Unlocking the regulatory code of RNA: launching the Human RNome Project. #RNA #RNAregulation #RNomeProject #GenomeBiology 🧪🧬 🖥️ genomebiology.biomedcentral.com/articles/10....

cellnatsci.com 😂

Interesting! The evolutionary angle in particular is very nice.

I did my PhD with Emma over 20 years ago (😊). Many congratulations to all of this years winners! 👏

Going through immigration doesn’t always put a smile on one’s face. But sometimes it does- Immigration officer (Delhi): so you’re a scientist? Me: Yes. IO: You know about Mendel‘s laws? Me: (a bit surprised..) Yes! IO: Beautiful experiment using peas. Me: Indeed! IO: Enjoy your visit.

Well done!

Woah! store.steampowered.com/app/4045010/...

One of my scientific heroes. journals.biologists.com/dev/article/...

The first 1 million prime numbers vizualized in 2D according to their prime factors (Umap) Source: johnhw.github.io/uma...

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds open.substack.com/pub/kellnerp...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

🤯

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

🤯 www.nature.com/articles/s41...

I’m most definitely a ‘mellow’ guy!

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!

#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u