Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity

AI tells you what you want to hear, statisticians usually tell you what you don't want to hear

Oooh, very interesting!

Beautiful work.

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...

Worth watching m.imdb.com/title/tt3859...

Unlocking the regulatory code of RNA: launching the Human RNome Project. #RNA #RNAregulation #RNomeProject #GenomeBiology 🧪🧬 🖥️ genomebiology.biomedcentral.com/articles/10....

cellnatsci.com 😂

Interesting! The evolutionary angle in particular is very nice.

I did my PhD with Emma over 20 years ago (😊). Many congratulations to all of this years winners! 👏

Going through immigration doesn’t always put a smile on one’s face. But sometimes it does- Immigration officer (Delhi): so you’re a scientist? Me: Yes. IO: You know about Mendel‘s laws? Me: (a bit surprised..) Yes! IO: Beautiful experiment using peas. Me: Indeed! IO: Enjoy your visit.

Well done!

Woah! store.steampowered.com/app/4045010/...

One of my scientific heroes. journals.biologists.com/dev/article/...

The first 1 million prime numbers vizualized in 2D according to their prime factors (Umap) Source: johnhw.github.io/uma...

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds open.substack.com/pub/kellnerp...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

🤯

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

🤯 www.nature.com/articles/s41...

I’m most definitely a ‘mellow’ guy!

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!

#OnThisDay in 1858, a seminal journal article comprised of papers by Alfred Russel Wallace FRS and Charles Darwin FRS on the theory of evolution by natural selection was published by the Linnean Society, the first public announcement of the theory of evolution. bit.ly/3k8fq4u

Beautiful work.

Very nice!

Just submitted a large grant application. Getting funding these days is so difficult that even a acknowledgement of receipt counts as a win! 😅

📣 New publication from our group! 📣 Our work showing that the leukemia mutated genes PHF6 and PHIP act as a chromatin complex to repress AML stemness is now out in @genesdev.bsky.social. Congratulations to first author @aishwarya2510.bsky.social, who defended her PhD on this work this month!

Hmmm….an Iron Maiden poster with a biscuit offering in the institute where I work??

The difference between Knowledge and Experience

Nature research paper: Mapping and engineering RNA-driven architecture of the multiphase nucleolus https://go.nature.com/44Tib11

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪

Scientists have corrected gene mutations in mice causing an ultra-rare disease by editing DNA directly in the brain with a single injection, a feat with profound implications for patients with neurological diseases. 🧬🧠🔬🧪

Paper in Nature 150 years ago. Beats reading any single-cell experiment…

Ha ha ha! 😂

Definitely worth watching!!

Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly" The assembly starts before the completion of the rRNA gene cluster processing🧵 www.nature.com/articles/s41...

Just out in Science: we demonstrate a micro-evolutionary shift in a single generation, involving thousands of genomic loci, giving younger ash trees more resistance to ash dieback, on average, than their parents www.science.org/doi/10.1126/science.adp2990

Woah!