Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠 #ASAP @jakobssonasap.bsky.social

Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3. www.biorxiv.org/content/10.1...

Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3. www.biorxiv.org/content/10.1...

Wonderful highlight of our work! 🧬

It was fun to write this preview with Larisa Okorokova. Congrats to @jakobssonlab.bsky.social and all coauthors for this nice piece of work !

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Join @embl.org for this conference exploring genetic and physiological impacts of transposable elements. Virtual registration is open until October 28. Learn more at plos.io/4nuqeZA.

Todays labmeeting became a tribute to Jane Goodall. Such an outstanding role model. 🙊

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains. www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains. www.biorxiv.org/content/10.1...

New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain. doi.org/10.1002/advs...

Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

first thing to share here! excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning www.biorxiv.org/content/10.1...

Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development. Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social www.biorxiv.org/content/10.1... Brief thread below (do people still do that?) 1/X

#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development. doi.org/10.1101/2025...

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development. doi.org/10.1101/2025...

A 🧵 to walk those interested through this paper...

New preprint of @trono-lab.bsky.social and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat www.biorxiv.org/content/10.1... #TEsky

Good times in Lund 🇸🇪 with @jakobssonlab.bsky.social. Beautiful campus, great food, and awesome science! Thanks Johan!

We had a fantastic guest speaker at our lab meeting this week who talked about the beautiful life of transposons and how they contributed to the evolution of the vertebrate brain. Thanks for the visit @cedricfeschotte.bsky.social !!

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

New online! Reactivation of retrotransposable elements is associated with environmental stress and ageing

Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c... 1/3

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons www.biorxiv.org/content/10.1...

Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium! We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes #NIHfundedResearch www.cell.com/cell-reports...

Today… 🇸🇪

Interesting study on cell-type-specific aging using single-nuclei transcriptomics in the human neocortex. Not clear to me based on this graph that pace of aging is striking different across cell types. doi.org/10.1101/2025... see also https://doi.org:10.1038/s41593-024-01742-z

New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. doi.org/10.1101/2025...

New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. doi.org/10.1101/2025...

Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n www.biorxiv.org/content/10.1... #TEsky

Don't miss the first edition of the CSH-Asia meeting on "The Repetitive and Mobile Genome" taking place in Suzhou, China. 📅 Abstract submission deadline extended: Feb 21, 2025 👉 www.csh-asia.org?content/2544 #transposon #mobileDNA #TEsky

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church. www.science.org/doi/10.1126/...

We had this wonderful paper for TE-JC this week. Will be very interesting (and challenging) to dissect the functional role all these elements play in early development… www.cell.com/cell/fulltex...

Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition www.nature.com/articles/s41... @mrvollger.bsky.social @naturegenet.bsky.social

📣 #EMBOMobileGenome is open for registrations! Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍 📜 Submit abstract by 29 July! 👉🏼 https://s.embl.org/mge25-01-bl

Our paper presenting spatial-Mux-seq is now out 🥳 pushing the frontiers of spatial Multiomics! It has been a great pleasure to work alongside with Yanxiang. DBiT is a really flexible platform and this paper clearly demonstrates that. Congrats to all involved! www.nature.com/articles/s41...

Online now! TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states 🖊️by Ilaria Panzeri & John Andrew Pospisilik and colleagues @ilariapanzeri.bsky.social @andrewpospisilik.bsky.social 👇 www.nature.com/articles/s43...

A mechanism for maintaining and spreading H3K9me3 in heterochromatin from the Fejes Toth and Aravin labs that depends on the local H3K9me3 density: HP1 dimers recruit SetDB1 to chromatin by simultaneously binding H3K9me3 on histone H3 and auto-methylated SetDB1. www.biorxiv.org/content/10.1...

🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social

New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social. LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development www.biorxiv.org/content/10.1...

If there's something we don't understand I assume transposons are responsible unless proven otherwise

Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics